Dr Anita Muthukaruppan
2010 The University of Auckland, PhD Obstetrics and Gynaecology
Anita is a Research Fellow who works with Professor Andrew Shelling in the Department of Obstetrics and Gynaecology, researching breast and gynaecological cancer. In 2016, she was awarded the New Zealand Breast Cancer Foundation Belinda Scott Fellowship to investigate the role of transcription factor FOXA1 in breast cancer.
She graduated with a Bachelor of Science with First Class Honours in Biomedical Science from The University of Auckland in 2003. Her honours dissertation investigated the roles of forkhead transcription factors in ovarian cancer, under the supervision of Professor Andrew Shelling.
After working as a research assistant at the Kolling Institute of Medical Research, Sydney, Australia for 1.5 years, Anita undertook her PhD, “Gene Expression Analysis in Breast Cancer”, at The University of Auckland 2006 under the supervision of Professor Andrew Shelling and Professor Cristin Print. She was a recipient of The University of Auckland Doctoral Scholarship and the Cancer Society of New Zealand Training Scholarship in Cancer Research, and graduated in 2011. After being away for a couple of years on maternity leave, Anita joined Andrew Shelling’s laboratory in March 2014.
Research | Current
Anita’s primary research interests are breast cancer pathogenesis, and identification of biomarkers for diagnosis and prognosis, and the prediction of treatment response in patients.
She is mainly interested in oestrogen receptor alpha (ESR1) and the oestrogen signalling pathway in breast cancer. She is also interested in how three transcription factors that are important in breast cancer: ESR1, FOXA1 and GATA3, may work together and contribute to the breast cancer development.
In addition, she is working on other projects involving vulval cancer and ovarian cancer, and has collaborative projects with the Department of Paediatrics and Auckland University of Technology.
Teaching | Current
Lectures on reproductive health for MEDSCI100G.
Anita has supervised three honours students to completion in projects in breast and ovarian cancer. In 2016, she is supervising an MD student researching vulval cancer.
In addition to research, Anita helps to manage the daily operations of the laboratory.
Areas of expertise
Breast cancer and gynaecological cancer.
Anita is a founding and committee member of the Faculty’s Postdoctoral Society, that helps with establishing working relationships, enabling research collaborations and enhancing professional development amongst postdoctoral researchers.
Selected publications and creative works (Research Outputs)
- Muthukaruppan, A., Arora, S. K., Blenkiron, C., & Shelling, A. N. (2018). Investigation of the role of transforming growth factor beta in the development and progression of granulosa cell tumours of the ovary. Paper presented at European-Society-for-Medical-Oncology Asia Congress, Singapore, Singapore. 23 November - 25 November 2018. Annals of Oncology. (pp. 1). 10.1093/annonc/mdy436.024
Other University of Auckland co-authors: Andrew Shelling, Cherie Blenkiron
- Muthukaruppan, A., Lasham, A., Blenkiron, C., Woad, K. J., Black, M. A., Knowlton, N., ... Shelling, A. N. (2017). Gene expression profiling of breast tumours from New Zealand patients. New Zealand Medical Journal, 130 (1464), 40-56.
Other University of Auckland co-authors: Michael Findlay, Annette Lasham, Cherie Blenkiron, Nicholas Knowlton, Andrew Shelling, Cristin Print
- Cheng, W.-T., Rosario, R., Muthukaruppan, A., Wilson, M. K., Payne, K., Fong, P. C., ... Blenkiron, C. (2017). MicroRNA profiling of ovarian granulosa cell tumours reveals novel diagnostic and prognostic markers. Clinical Epigenetics, 9 (72).10.1186/s13148-017-0372-0
Other University of Auckland co-authors: Andrew Shelling, Michelle Wilson, Cherie Blenkiron
- Muthukaruppan, A., Lasham, A., Woad, K., Black, M., Blenkiron, C., Miller, L., ... Shelling, A. (2017). Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors. Clinical Breast Cancer, 17 (2), 139-153. 10.1016/j.clbc.2016.09.001
Other University of Auckland co-authors: Michael Findlay, Andrew Shelling, Cristin Print, Annette Lasham, Cherie Blenkiron
- Blenkiron, C., Simonov, D., Muthukaruppan, A., Tsai, P., Dauros, P., Green, S., ... Phillips, A. (2016). Uropathogenic Escherichia coli releases extracellular vesicles that are associated with RNA. PLoS One, 11 (8).10.1371/journal.pone.0160440
Other University of Auckland co-authors: Cristin Print, Jiwon Hong, Simon Swift, Cherie Blenkiron, Peter Tsai, Anthony Phillips, Priscila Dauros Singorenko
- Simonov, D., Blenkiron, C., Muthukaruppan, A., Dauros-Singorenko, P., Holloway, H., Ross, J., ... Swift, S. (2016). Membrane vesicles released from uropathogenic Escherichia coli deliver RNA cargo to human bladder cells. Paper presented at the 24th Australian Conference on Microscopy and Microanalysis (ACMM24), Melbourne. 31 January - 4 February 2016. Related URL.
Other University of Auckland co-authors: Cherie Blenkiron, Jacqueline Ross, Cristin Print, Anthony Phillips, Simon Swift
- Simonov, D., Blenkiron, C., Muthukaruppan, A., Print, C., Phillips, A., & Swift, S. (4/11/2015). Transcriptional response of human bladder cells to UPEC 536 membrane vesicles. Poster presented at NZMS Conference 2015, Rotorua. Microbial Communities and Us. Related URL.
Other University of Auckland co-authors: Simon Swift, Cherie Blenkiron, Cristin Print, Anthony Phillips
- Simonov, D., Blenkiron, C., Muthukaruppan, A., Print, C., Phillips, A., & Swift, S. (2015). Transcriptional response of human bladder cells to UPEC 536 membrane vesicles. Paper presented at National Symposium on Infectious Diseases and Antimicrobial Resistance: Challenges, Opportunities and Successes, Rydges Hotel, Queenstown, New Zealand. 30 August - 31 August 2015. Related URL.
Other University of Auckland co-authors: Cherie Blenkiron, Cristin Print, Anthony Phillips, Simon Swift