Professor David Barker
- 2001 - University of Sydney, Australia, PhD, Organic Chemistry
- 1997 - University of Sydney, Australia, BSc (Hons 1st Class), Honours in Organic Chemistry
- 2001-2003 University of New South Wales– National Health & Medical Research Council of Australia Research Associate
Research | Current
My research focuses on the synthesis of organic molecules and whilst doing so exploring fundamental chemical principles to aid the development of efficient synthetic methods, the preparation of novel molecular structures and to answer complex biological questions.
At present my research group is working on number of different research areas including, the development of new synthetic methodologies enabling he preparation of DNA-binding molecules, the synthesis of bioactive lignans (plant derived natural products) and the synthesis of complex alkaloids as novel treatments for dementia and cancer. Along with this my research group is active in the development of new synthetic methods to prepare organic molecules rich in heteroatoms, such as nitrogen, oxygen and sulfur. I also am active in a number of national and international multidisciplinary research projects working on areas such as the development of new polymeric materials, natural product synthesis and determination and the synthesis of labelled wine components for wine profiling.
My current research focuses on numerous areas including
- Synthesis of 1,4-benzodioxane lignans biological active and have a wide range of activites including cytotoxicity, acting as alpha-or beta-blocking agents useful in antidepression or antihypertension therapy.
- Synthesis of bioactive heterocycles such as thieno- and furano-pyridines. These compounds have been shown to inhibit a number of important enzymes involved in cell regulation and are being analysed for their anticancer activity.
- Synthesis of complex dineolignans, which have wide ranging biological activities including HIF-1 inhibition (an anticancer target) and neuroprotective properties.
- Synthesis of novel heterocyclic frameworks based on substituted pyrroles.
- Synthesis of complex bioactive marine natural products that contain substituted pyrroles. Current molecules of interest are: Trikentramine, the Mukanadins, Lamellarins and Kottamides
- Synthesis and modulation of bioactive compounds derived from grape material
- Synthesis of novel polymeric materials including advanced conducting polymers
- Synthesis of isotopically labelled natural products for use in quantitative analysis
- Synthesis of novel antibacterial materials from renewable, bio-based, sources
Teaching | Current
I current teach the following courses.
CHEM 110, CHEM 253, CHEM 330, CHEM 390, CHEM 735 and PHARM 312
Rebecca Jelley, PhD 2015- (with Dr Bruno Fedrizzi)
Shi Min Tan, PhD 2015- (with Dr Bruno Fedrizzi)
Stephen Lo, PhD 2016-
Min Wang PhD 2016- (with Prof. Jadranka Travas-Sejdic)
Hua Lyu PhD 2017- (with Dr. Bruno Fedrizzi)
Natalie Haverkate PhD 2017-
Delsa Pulickal Joseph PhD 2017-
Mohinder Naiya PhD 2017-
Ziyao Wan PhD 2018-
Andrew Twidle PhD 2018-
Emily Paulin PhD 2018-
Shaun Rees PhD 2018-
Tuan Minh (Marcus) Luong PhD 2019-
Luka Posa PhD 2020-
Sok Teng (Amy) Tong (2009), Kirsten Goodall (2010), Kevin Sparrow (2011), Gul Shahzada Khan (2011), Claire Rye (2011), Glenn Archibald (2011), Anupama Rao Gulur Srinivas (2013), Benjamin Dickson (2013), Emma Dickson (2013), Nora Dittrich (2014), Lisa Pilkington (2015), Michelle van Rensburg (2016), Mona Damavandi (2017), Eunkyung (Kelly) Jung (2017), Wai-Chi (Eddie) Chan (2017), Samuel Davidson (2018), Nina Duhamel (2018), Rueben White (2019)
Christopher Ritchie (2005), Kirsten Goodall (2006), Anna Mai (2006), Joy Min-Chih Hung (2012), Soo-Min (Emma) Song (2012), Stephen Lo (2015), Harpreet Kaur Brar (2017), Natalie Haverkate (2017), Ziyao Wan (2017), Andrew Twidle (2018), Emily Paulin (2018), Tuan Minh (Marcus) Luong (2019), Hayden Jones-Moore (2019), Mikael Johannisson-Wallman (2019)
Selected publications and creative works (Research Outputs)
- Pilkington, L. I., Sparrow, K., Rees, S. W. P., Paulin, E. K., van Rensburg, M., Xu, C. S., ... Leung, E. (2020). Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors. European journal of medicinal chemistry, 19110.1016/j.ejmech.2020.112162
Other University of Auckland co-authors: Ivanhoe Leung, Lisa Pilkington, Shaun Rees, Emily Paulin, Ries Langley, Euphemia Leung
- Jelley, R. E., Duhamel, N., Barker, D., & Fedrizzi, B. (2020). A convenient synthesis of amino acid-derived precursors to the important wine aroma 3-sulfanylhexan-1-ol (3SH). Tetrahedron Letters, 61 (13).10.1016/j.tetlet.2020.151663
Other University of Auckland co-authors: Rebecca Jelley, Bruno Fedrizzi
- Wang, M., Kee, S., Barker, D., & Travas-Sejdic, J. (2020). Highly stretchable, solution-processable, and crosslinkable poly(3,4-ethylenedioxithiophene)-based conjugated polymers. EUROPEAN POLYMER JOURNAL, 12510.1016/j.eurpolymj.2020.109508
- Eurtivong, C., Pilkington, L. I., van Rensburg, M., White, R. M., Brar, H. K., Rees, S., ... Leung, I. K. H. (2020). Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. European journal of medicinal chemistry, 18710.1016/j.ejmech.2019.111919
Other University of Auckland co-authors: Ivanhoe Leung, Lisa Pilkington, Euphemia Leung, Shaun Rees, Emily Paulin
- Patel, K. D., De Zoysa, G. H., Kanamala, M., Patel, K., Pilkington, L. I., Barker, D., ... Sarojini, V. (2020). Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations. Journal of medicinal chemistry, 63 (1), 334-348. 10.1021/acs.jmedchem.9b01694
Other University of Auckland co-authors: Zimei Wu, Lisa Pilkington, Heru De Zoysa
- Wang, M., Kee, S., Baek, P., Ting, M. S., Zujovic, Z., Barker, D., & Travas-Sejdic, J. (2019). Photo-patternable, stretchable and electrically conductive graft copolymers of poly(3-hexylthiophene). POLYMER CHEMISTRY, 10 (46), 6278-6289. 10.1039/c9py01428d
Other University of Auckland co-authors: Jadranka Travas-Sejdic
- Deed, R. C., Pilkington, L. I., Herbst-Johnstone, M., Miskelly, G. M., Barker, D., & Fedrizzi, B. (2019). A new analytical method to measure S-methyl-l-methionine in grape juice reveals the influence of yeast on dimethyl sulfide production during fermentation. Journal of the science of food and agriculture, 99 (15), 6944-6953. 10.1002/jsfa.9983
Other University of Auckland co-authors: Rebecca Deed, Lisa Pilkington, Gordon Miskelly, Bruno Fedrizzi
- Leung, E., Pilkington, L. I., Naiya, M. M., Barker, D., Zafar, A., Eurtivong, C., & Reynisson, J. (2019). The cytotoxic potential of cationic triangulenes against tumour cells. MEDCHEMCOMM, 10 (11), 1881-1891. 10.1039/c9md00305c
Other University of Auckland co-authors: Euphemia Leung, Lisa Pilkington