Professor Greg O'Grady
BhB MBChB PhD FRACS
Professor O'Grady is a general and lower gastrointestinal surgeon at Auckland City Hospital, and principal investigator at the Department of Surgery (FMHS) and Auckland Bioengineering Institute. He has cross-disciplinary expertise in surgery, translational physiology, medical device development, and bioengineering. His work aims to improve surgical safety, reduce the risks and burdens of surgical complications, and to enhance the long term quality of life of surgical patients.
He directs the Surgical Engineering Lab and is a member of the Surgical Translational Research Centre. His research is funded by a New Zealand HRC Programme Grant, as well as grants from the NIH, MedTech CoRE and the Royal Australasian College of Surgeons. He is also currently Chair of the Australasian Surgical Research Society.
Research | Current
Professor O'Grady has broad clinical and research interests in medical device development, translational physiology, clinical trials and electrophysiology. He particularly enjoys working with teams of engineers, physiologists and clinicians in collaborative roles.
Current research activities include:
The Surgical Engineering Lab
Professor O'Grady founded the Surgical Engineering Lab in 2017 to develop innovative medical devices, as a cross-faculty initiative between the Department of Surgery and Auckland Bioengineering Institute. We develop medical devices with commercial potential from within the University. Our engineers design, prototype, and validate devices in-house, and conduct pre-clinical and clinical trials for selected projects, and we are actively involved in commercialisation.
High-resolution electrical mapping of the gut
This longstanding cross-disciplinary project involves developing and applying novel devices and software for recording, analysing and electrically-stimulating GI bioelectricity. Our devices are being applied in a translational research program seeking to better understand and treat important functional disorders of the stomach, small and large intestines, including in primary motility disorders and post-operative states. This innovative research program has received multiple international awards and is currently funded by an HRC Programme Grant.
This broad program is a collaboration between the Auckland Colorectal Research Group (led by Professor Ian Bissett), researchers from the Auckland Bioengineering Institute and international partners. We are applying innovative methods of gut sensing and monitoring, translational physiology studies, neuromodulation, and computational modelling to improve the fundamental understanding of gut motility and problems arising after gastrointestinal surgery.
Teaching | Current
Professor O'Grady teaches as part of the MBChB IV program, and participates in training surgical registrars and fellows at Auckland City Hospital.
Many postgraduate students are currently active in our groups at PhD, Masters and Honours levels, across surgical / medical and bioengineering disciplines. We also host numerous postdoctoral researchers and interns.
Recent Selected Awards
2019 The John Mitchell Crouch Fellowship, Royal Australasian College of Surgeons
2016 The Vice Chancellor's Research Excellence Award
2015 Emerging Researcher Prize for 'Outstanding Early Career Research', Physiological Society of NZ
2014 The John Corboy Medal, Royal Austalasian College of Surgeons
2012 Certificate of Outstanding Service to the Fellowship, Royal Australasian College of Surgeons
2012 John Ham Medal, General Surgeons Australia
2011 The 'Masters Award in Gastroenterology' of the American Gastroenterological Association, for 'Outstanding Achievement in Digestive Sciences'
Professor O'Grady is Chair of the Austalasian Surgical Research Society, and sits on a number of professional surgical boards. He has previously held representative roles on the Councils of the Royal Australasian College of Surgeons and the Colorectal Surgical Society of Australia and New Zealand. He also serves as a Director in two University spin-out companies that he has co-founded: The Insides Company and Alimetry Ltd.
Selected publications and creative works (Research Outputs)
- Wang, T. H.-H., Angeli, T. R., Beban, G., Du, P., Bianco, F., Gibbons, S. J., ... O'Grady G (2019). Slow-wave coupling across a gastroduodenal anastomosis as a mechanism for postsurgical gastric dysfunction: evidencefor a "gastrointestinal aberrant pathway". American journal of physiology. Gastrointestinal and liver physiology, 317 (2), G141-G146. 10.1152/ajpgi.00002.2019
Other University of Auckland co-authors: John Windsor, Tim Angeli-Gordon
- Keane, C., Park, J., Öberg S, Wedin, A., Bock, D., O'Grady G, ... Angenete, E. (2019). Functional outcomes from a randomized trial of early closure of temporary ileostomy after rectal excision for cancer. The British journal of surgery, 106 (5), 645-652. 10.1002/bjs.11092
Other University of Auckland co-authors: Ian Bissett, Celia Keane
- Alighaleh, S., Cheng, L. K., Angeli, T. R., Amiri, M., Sathar, S., O'Grady G, & Paskaranandavadivel, N. (2019). A novel gastric pacing device to modulate slow waves and assessment by high-resolution mapping. IEEE transactions on bio-medical engineering10.1109/tbme.2019.2896624
Other University of Auckland co-authors: Tim Angeli-Gordon, Nira Paskaranandavadivel
- O'Grady G, Angeli, T. R., Paskaranandavadivel, N., Erickson, J. C., Wells, C. I., Gharibans, A. A., ... Du, P. (2019). Methods for High-Resolution Electrical Mapping in the Gastrointestinal Tract. IEEE reviews in biomedical engineering, 12, 287-302. 10.1109/rbme.2018.2867555
Other University of Auckland co-authors: Tim Angeli-Gordon, Nira Paskaranandavadivel, Armen Gharibans
- Vather, R., O'Grady G, Lin, A. Y., Du, P., Wells, C. I., Rowbotham, D., ... Bissett, I. P. (2018). Hyperactive cyclic motor activity in the distal colon after colonic surgery as defined by high-resolution colonic manometry. The British journal of surgery, 105 (7), 907-917. 10.1002/bjs.10808
Other University of Auckland co-authors: Ian Bissett
- Berry, R., Cheng, L. K., Du, P., Paskaranandavadivel, N., Angeli, T. R., Mayne, T., ... O'Grady G (2017). Patterns of abnormal gastric pacemaking after sleeve gastrectomy defined by laparoscopic high-resolution electrical mapping. Obesity Surgery, 27 (8), 1929-1937. 10.1007/s11695-017-2597-6
Other University of Auckland co-authors: Nira Paskaranandavadivel, Tim Angeli-Gordon, Leo Cheng, Peng Du
- Lin, A., Du, P., Dinning, P., Arkwright, J., Kamp, J., Cheng, L., ... O'Grady G (2017). High-resolution anatomic correlation of cyclic motor patterns in the human colon: Evidence of a rectosigmoid brake. American Journal of Physiology - Gastrointestinal and Liver Physiology, 312 (5), G508-G515. 10.1152/ajpgi.00021.2017
Other University of Auckland co-authors: Ian Bissett, Peng Du, Leo Cheng
- Vather, R., O'Grady G, Arkwright, J. W., Rowbotham, D. S., Cheng, L. K., Dinning, P. G., & Bissett, I. P. (2016). Restoration of normal colonic motor patterns and meal responses after distal colorectal resection. British Journal of Surgery, 103 (4), 451-461. 10.1002/bjs.10074
Other University of Auckland co-authors: Ian Bissett, Leo Cheng