Dr Adrian Blaser

MSc PhD Bern

Biography

Adrian Blaser obtained his Masters and PhD in Chemistry from the University of Bern, Switzerland. After a postdoctoral position with Professor Margaret Brimble at the University of Auckland, Adrian was appointed as a Research Fellow in the Centre designing and developing novel drugs for cancer treatment.

Research interests

Research | Current

After 3 years on a variety of projects ranging from developing a backup compound for a drug in clinical trial phase I on erbB2 Inhibition to developing a new Antibacterial agent I am now working on a project in collaboration with the Global Alliance of Tuberculosis (GATB) to develop a backup drug of PA-824, a new antibacterial agent against Mycobacterium tuberculosis. The aim of the project is to develop an efficient drug with a novel mode of action that avoids cross-resistance with existing drugs, and will simultaneously address many pressing current medical needs.

I am now in charge of the NMR facility at the ACSRC.

Distinctions/Honours

  • Appointed Justice of the Peace for New Zealand, 12 November 2014
  • Appointed Honorary Consul for Switzerland in Auckland, 1 January 2019

Committees/Professional groups/Services

Justice of the Peace service at Grafton Campus (by appointment) and City Drop In Sessions

Selected publications and creative works (Research Outputs)

  • Blaser, A., Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline. Bioorganic & medicinal chemistry, 27 (7), 1283-1291. 10.1016/j.bmc.2019.02.025
    Other University of Auckland co-authors: Bill Denny, Peter Choi, Brian Palmer
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorganic & medicinal chemistry, 27 (7), 1292-1307. 10.1016/j.bmc.2019.02.026
    Other University of Auckland co-authors: Bill Denny, Peter Choi, Brian Palmer
  • Choi, P., Sutherland, H., Tong, A., Conole, D., Blaser, A., Cooper, C., ... Palmer, B. (31/3/2019). Next-generation bedaquiline for the treatment of tuberculosis. Poster presented at 257th National Meeting of the American-Chemical-Society (ACS), Orlando, FL. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
    Other University of Auckland co-authors: Peter Choi, Bill Denny, Brian Palmer
  • Black, S. L., O'Connor PD, Boyd, M., Blaser, A., & Kendall, J. D. (2018). Synthesis and 1 H, 13 C and 15 N NMR characterisation of substituted Pyrazolo[4,3- c ]quinolines and related compounds. Tetrahedron, 74 (22), 2797-2806. 10.1016/j.tet.2018.04.061
    URL: http://hdl.handle.net/2292/42422
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Blaser, A., Franzblau, S. G., ... Denny, W. A. (2018). Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles. Bioorganic & medicinal chemistry, 26 (8), 1797-1809. 10.1016/j.bmc.2018.02.026
    URL: http://hdl.handle.net/2292/44736
    Other University of Auckland co-authors: Peter Choi, Bill Denny, Brian Palmer, Hamish Sutherland
  • Thompson, A. M., O'Connor PD, Marshall, A. J., Blaser, A., Yardley, V., Maes, L., ... Chatelain, E. (2018). Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis. Journal of medicinal chemistry, 61 (6), 2329-2352. 10.1021/acs.jmedchem.7b01581
    URL: http://hdl.handle.net/2292/44743
    Other University of Auckland co-authors: Andrew Thompson, Bill Denny
  • Choi, P. J., Sutherland, H. S., Tong, A. S., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Motte, M. (2017). Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units. Bioorganic and Medicinal Chemistry Letters, 27 (23), 5190-5196. 10.1016/j.bmcl.2017.10.042
    URL: http://hdl.handle.net/2292/44451
    Other University of Auckland co-authors: Hamish Sutherland, Peter Choi, Bill Denny, Brian Palmer
  • Tong, A. S., Choi, P. J., Blaser, A., Sutherland, H. S., Tsang, S. K., Guillemont, J., ... Van den Broeck, W. (2017). 6-cyano analogues of bedaquiline as less lipophilic and potentially safer diarylquinolines for tuberculosis. ACS Medicinal Chemistry Letters, 8 (10), 1019-1024. 10.1021/acsmedchemlett.7b00196
    URL: http://hdl.handle.net/2292/44180
    Other University of Auckland co-authors: Peter Choi, Hamish Sutherland, Bill Denny, Brian Palmer

Identifiers

Contact details

Alternative contact

DDI +64 9 923 8228

Mobile +64 21 232 7998

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 125
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links