Mr Andy Chun Yip Lo

MSc in Applied Mathematics, University of Auckland

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Doctoral Candidate - Doctor of Philosophy

Biography

Andy obtained his MSc in Applied Mathematics in 2016 at the University of Auckland where he was tasked to develop a novel model of the calcium dynamics of airway smooth muscle cells that takes into account recent experimental findings. Prior to this, he completed a BSc in Applied Mathematics and Physics (2010-14), and a BSc(Hons) in Applied Mathematics in 2015.

Research | Current

The Role of the TBX5-Driven Regulatory Network in the Manifestation and Sustainability of Atrial Fibrillation, and in the Development of Patient-Specific Drug Treatment

My research involves the development of computational models to investigate the mechanisms by which impaired gene expression in T-box transcription factor TBX5 and paired-like homeodomain 2 PITX2 leads to atrial fibrillation (AF). Both genes are primarily known for the role they play in cardiac development and rhythm control during embryogenesis and have been implicated by multiple genome-wide assocation studies to be strongly associated with the arrhythmia. These genes work antagonistically with one another in regulating the gene expressions of several ion and calcium handling channels through a multi-tiered regulatory network, and cruical knockout mice studies have demonstrated that impairments in this network can generate various substrates to AF.

The aim of this research is to establish groundwork for an antiarrhythmic drug therapy treatmet that is tailored towards the individual genetics of AF patients rather than one that is based on empiric approaches.

Supervisor

Dr Jichao Zhao

Distinctions/Honours

Rosanna Degani Young Investigator Award Semi-Finalist, 2019

For the Computing in Cardiology conference held in September at Singapore, my paper was chosen by a panel of judges to be one of the 8 finalists. I was also invited to give a presentation at the closing plenary of the conference.

Responsibilities

Assignment and test/exam marker

Engineering Science (March 2019 to present)

Areas of expertise

  • Mathematical physiology
  • Calcium dynamics

Committees/Professional groups/Services

University of Auckland Data Science Club

  • Vice-president (November 2019 to present)
  • Treasurer (Marck 2018 to 2019 November)

Selected publications and creative works (Research Outputs)

  • Lo, A. C. (2016). The Inhibition by Bitter Taste Receptors of the IP3 Receptor, and the Inclusion of a Bidirectional SERCA Pump The University of Auckland. ResearchSpace@Auckland.
    URL: http://hdl.handle.net/2292/31113

Identifiers

Contact details

Primary office location

AUCKLAND BIOENGINEERING HOUSE - Bldg 439
Level 1, Room 101
70 SYMONDS ST
GRAFTON
AUCKLAND 1010
New Zealand

Social links

Web links