Dr David Charles Goldstone

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Associate Professor


David Goldstone is an Associate Professor in Structural Biology and previosuly held a Rutherford Discovery Fellowship. He has been a member of the Faculty since 2012. He obtained his PhD form the University of Auckland and was a post-doctoral fellow with the AgResearch Structural Biology Lab and MRC National Institute for Medical Research in London, UK before returning to NZ.

Research | Current

Structure and Function of Anti-Retroviral Host Proteins

I am interested in how HIV and other retroviruses interact with components of the host cell during infection. These interactions govern both the ability of the virus to reproduce, and the ability of the cell to block and contain infection. Of particular interest are members of the TRIM protein family that can recognise retroviral components within the cell and then act to block the viral lifecycle, disrupting infection. We aim to characterise these proteins and the interactions they make using X-ray crystallography, small-angle X-ray scattering and other biophysical techniques.

How to metal based chemotherapeutics target proteins?

Platinum compounds form the foundation of many treatment regimens for cancer. However, these compounds are promiscious lacking the specificity of other chemotherapeutic compounds. This results in off target and side-effects that limit their usability in treatment. We are interested in how metal-based compounds interact with proteins, and understanding how we can generate specificity to improve treatment options for cancer patients. 

Teaching | Current

BIOSCI201 - Course director - Module B: The central dogma of molecular biology

BIOSCI203 - Module C: Protein assembly and molecular machines

BIOSCI759 - HIV evasion of cellular defense to infection

BIOSCI746 - Protein assembly and its investgation by AUC and light-scattering


Rutherford Discovery Fellow


Chair SBS Research Committee

Member - SBS Executive Committee

Member - Faculty of Science Research Steering Committee

Areas of expertise

Structural Biology, Protein-protein interactions, Protein ligand interactions, Small Angle X-ray scattering

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Acton, O., Grant, T., Nicastro, G., Ball, N. J., Goldstone, D. C., Robertson, L. E., ... Stoye, J. P. (2019). Structural basis for Fullerene geometry in a human endogenous retrovirus capsid. Nature communications, 10 (1)10.1038/s41467-019-13786-y
  • Sun, Y., Keown, J. R., Black, M. M., Raclot, C., Demarais, N., Trono, D., ... Goldstone, D. C. (2019). A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family. Journal of molecular biology, 431 (14), 2511-2527. 10.1016/j.jmb.2019.05.002
  • Keown, J. R., Black, M. M., Ferron, A., Yap, M., Barnett, M. J., Pearce, F. G., ... Goldstone, D. C. (2018). A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins. The Journal of biological chemistry, 293 (47), 18378-18386. 10.1074/jbc.ra118.004202
  • Sullivan, M. P., Nieuwoudt, M. K., Bowmaker, G. A., Lam, N. Y. S., Truong, D., Goldstone, D. C., & Hartinger, C. G. (2018). Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct. Chemical communications (Cambridge, England), 54 (48), 6120-6123. 10.1039/c8cc02433b
    Other University of Auckland co-authors: Christian Hartinger, Matthew Sullivan, Michel Nieuwoudt, Graham Bowmaker, Cather Simpson
  • Pinheiro, J., Biboy, J., Vollmer, W., Hirt, R., Keown, J., Artuyants, A., ... Simoes-Barbosa, A. (2018). The protozoan Trichomonas vaginalis targets bacteria with laterally-acquired NlpC/P60 peptidoglycan hydrolases. 10.1101/320382
    Other University of Auckland co-authors: Augusto Barbosa
  • Goldstone, D. C., Walker, P. A., Calder, L. J., Coombs, P. J., Kirkpatrick, J., Ball, N. J., ... Stoye, J. P. (2014). Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice. Proceedings of the National Academy of Sciences of the United States of America, 111 (26), 9609-9614. 10.1073/pnas.1402448111
  • Goldstone, D. C., Flower, T. G., Ball, N. J., Sanz-Ramos, M., Yap, M. W., Ogrodowicz, R. W., ... Stoye, J. P. (2013). A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid. PLoS Pathog, 9 (5)10.1371/journal.ppat.1003376
  • Goldstone, D. C., Ennis-Adeniran, V., Hedden, J. J., Groom, H. C. T., Rice, G. I., Christodoulou, E., ... Yap, M. W. (2011). HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. NATURE, 480 (7377), 379-383. 10.1038/nature10623


Contact details

Primary office location

Level 4, Room 4004
New Zealand

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