Dr David Charles Goldstone
David Goldstone is a Rutherford Discovery Fellow and Senior Lecturer in Structural Biology. He has been a member of the Faculty since 2012. He obtained his PhD form the University of Auckland and was a post-doctoral fellow with the AgResearch Structural Biology Lab and MRC National Institute for Medical Research in London, UK before returning to NZ.
Research | Current
Structure and Function of Anti-Retroviral Host Proteins
I am interested in how HIV and other retroviruses interact with components of the host cell during infection. These interactions govern both the ability of the virus to reproduce, and the ability of the cell to block and contain infection. Of particular interest are members of the TRIM protein family that can recognise retroviral components within the cell and then act to block the viral lifecycle, disrupting infection. We aim to characterise these proteins and the interactions they make using X-ray crystallography, small-angle X-ray scattering and other biophysical techniques.
Rutherford Discovery Fellow
Areas of expertise
Selected publications and creative works (Research Outputs)
- Goldstone, D. C., Walker, P. A., Calder, L. J., Coombs, P. J., Kirkpatrick, J., Ball, N. J., ... Stoye, J. P. (2014). Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice. Proceedings of the National Academy of Sciences of the United States of America, 111 (26), 9609-9614. 10.1073/pnas.1402448111
- Goldstone, D. C., Flower, T. G., Ball, N. J., Sanz-Ramos, M., Yap, M. W., Ogrodowicz, R. W., ... Stoye, J. P. (2013). A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid. PLoS Pathog, 9 (5)10.1371/journal.ppat.1003376
- Goldstone, D. C., Ennis-Adeniran, V., Hedden, J. J., Groom, H. C. T., Rice, G. I., Christodoulou, E., ... Yap, M. W. (2011). HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. NATURE, 480 (7377), 379-383. 10.1038/nature10623
- Goldstone, D. C., Yap, M. W., Robertson, L. E., Haire, L. F., Taylor, W. R., Katzourakis, A., ... Taylor, I. A. (2010). Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface. Cell Host and Microbe, 8 (3), 248-259. 10.1016/j.chom.2010.08.006