Professor Jillian Cornish

Professorial Research Fellow

In: Medicine » School of Medicine » Faculty of Medical and Health Sciences

Biography

Professor Cornish leads the Cell and Molecular Biology Bone/Joint Research Group in the Department of Medicine, the University of Auckland and is principal investigator of the Regenerative Medicine theme in the MedTech CoRE.

The team is investigating the actions of novel hormones and growth factors on the musculoskeletal system and we have in place a set of in vitro and in vivo models to make a comprehensive assessment of novel skeletal active factors. The team also has expertise in evaluating scaffolds with and without growth factors for tissue engineering, particularly in bone regeneration and tendon repair and have established pre-clinical models to support this.

The team is investigating the mechanism of action of a number of peptides and lipids that are anabolic to bone (i.e., encourage bone growth) and for which we hold international patents. Considering that there exists a principal challenge in the treatment of osteoporosis to find factors that are anabolic to bone growth, the potential exists to explore lactoferrin in a therapeutic as well as nutriceutical role. In addition, in the regenerative medicine area we are working with potential scaffolds to aid bone and tendon tissue repair locally in the body.

Research | Current

Skeletal cell
Molecular biology
Orthopaedic research
Skeletal Regenerative Medicine/Tissue Engineering

Selected publications and creative works (Research Outputs)

Naot, D., Watson, M., Callon, K. E., Tuari, D., Musson, D. S., Choi, A. J., ... Dickinson, M. (2016). Reduced bone density and cortical bone indices in female adiponectin-knockout mice. Endocrinology, 157 (9), 3550-3561. 10.1210/en.2016-1059
URL: http://hdl.handle.net/2292/31898
Other University of Auckland co-authors: Andrew Grey, David Musson, Dorit Naot, Justin Fernandez, Karen Callon, Maureen Watson, Greg Gamble
Musson, D. S., Naot, D., Chhana, A., Matthews, B. G., McIntosh, J. D., Lin, S. T. C., ... Lesage, S. (2015). In vitro evaluation of a novel non-mulberry silk scaffold for use in tendon regeneration. Tissue Engineering: Part A, 21 (9-10), 1539-1551. 10.1089/ten.tea.2014.0128
URL: http://hdl.handle.net/2292/42757
Other University of Auckland co-authors: Dorit Naot, Julie McIntosh, Ashika Chhana, Karen Callon, David Musson, Rod Dunbar, Sandy Lin, Brya Matthews
Naot, D., & Cornish, J. (2014). Cytokines and hormones that contribute to the positive association between fat and bone. Frontiers in Endocrinology, 5, 1-9. 10.3389/fendo.2014.00070
URL: http://hdl.handle.net/2292/30646
Other University of Auckland co-authors: Dorit Naot
Williams, G. A., Wang, Y., Callon, K. E., Watson, M., Lin, J.-M., Lam, J. B. B., ... Naot, D. (2009). In vitro and in vivo effects of adiponectin on bone. Endocrinology, 150 (8), 3603-3610. 10.1210/en.2008-1639
URL: http://hdl.handle.net/2292/15183
Other University of Auckland co-authors: Dorit Naot, Ian Reid
Cornish, J., MacGibbon, A., Lin, J.-M., Watson, M., Callon, K. E., Tong, P. C., ... Grey, A. B. (2008). Modulation of osteoclastogenesis by fatty acids. Endocrinology, 149 (11), 5688-5695. 10.1210/en.2008-0111
URL: http://hdl.handle.net/2292/15186
Other University of Auckland co-authors: Karen Callon, Andrew Grey, Dorit Naot, Ian Reid, Jian-ming Lin, Maureen Watson
Cornish, J., Callon, K. E., Naot, D., Palmano, K. P., Banovic, T., Bava, U., ... Chen, Q. (2004). Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology, 145 (9), 4366-4374. 10.1210/en.2003-1307
Other University of Auckland co-authors: Karen Callon, Dorit Naot, Maureen Watson, Andrew Grey, Usha Bava, Jian-ming Lin, Qi Chen, Ian Reid
Cornish, J., Callon, K. E., Bava, U., Lin, C., Naot, D., Hill, B. L., ... Nicholson, G. C. (2002). Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol, 175 (2), 405-415.
Other University of Auckland co-authors: Karen Callon, Usha Bava, Dorit Naot, Andrew Grey, Ian Reid
Cornish, J., Callon, K. E., Bava, U., Kamona, S. A., Cooper, G. J. S., & Reid, I. R. (2001). Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development. BONE, 29 (2), 162-168. 10.1016/S8756-3282(01)00494-X
Other University of Auckland co-authors: Karen Callon, Usha Bava, Garth Cooper, Ian Reid