Dr Julie Ching-Hsia Lim
BSc/MSc(First class honours)/PhD (University of Auckland)
Dr Julie Lim graduated from the University of Auckland with a BSc, MSc and then PhD in Biological Sciences in 2004. Following her PhD, she was offered a post-doctoral position in the Molecular Vision Laboratory to study the lens of the eye and investigate the mechanisms involved in cataract formation, the leading cause of blindness in the world. She now leads her own research group investigating the contribution of oxidative stress to a number of different age related eye diseases that affect the different tissues of the eye including the lens, the retina and the cornea.
Research | Current
Dr Julie Lim is a Senior Lecturer in the Molecular Vision Laboratory located in the Department of Physiology. The goal of her research is to the delay the onset of age related eye diseases by identifying targeted strategies for minimising oxidative stress. A key focus is to understand the interplay between reactive oxygen species, antioxidant defence systems and redox balance in the different tissues of the eye to maintain overall ocular health.
Keywords: antioxidants, oxidative stress, redox balance, age related eye diseases
Teaching | Current
OPTOM 272: Structure and Function of the Visual System
MEDSCI 206: Principles of Neuroscience
MEDSCI 316: Sensory Neuroscience: from molecules to disease
MEDSCI 739: Advanced Sensory Neuroscience
MEDSCI 744: Project Design in Biomedical Science
A selection of some of the postgraduate students supervised by Dr Lim at the PhD, Masters and Honours level:
Ankita Umapathy (PhD student): Mapping of glutathione metabolism and transport pathways in the aging eye-is the lens a reservoir of glutathione?
Renita Martis (PhD student): The role of the cystine/glutamate exchanger in maintaining redox balance in the eye
Luis Knight (PhD student): The xCT knockout mouse: a novel animal model for stuyding age related changes in the retina
Jinny Kim (MSc student): Inter-tissue Crosstalk between the lens and ocular humours
Zhou-ai Wang (Honours student): Molecular identification and characterisation of circadian clock genes in the lens
Vithushiya Yoganandarajah (Honours student) : Characterisation of glutathione synthesis pathways in the rat cornea
2021. National Foundation for Eye Research Cataract Research Award
2020. Butland Award for Early Career Excellence in Teaching
2010. Sir Charles Hercus Health Research post-doctoral fellowship
2010. Zonta Women In Science Award
2007. Foundation for Research in Science and Technology post doctoral fellowship
Areas of expertise
Antoxidants, oxidative stress and the aging eye
Selected publications and creative works (Research Outputs)
- Li, B., Kim, J.-Y., Martis, R. M., Donaldson, P. J., & Lim, J. C. (2020). Characterisation of Glutathione Export from Human Donor Lenses. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 9 (8)10.1167/tvst.9.8.37
Other University of Auckland co-authors: Paul Donaldson
- Lim, J. C., Li, I., Donaldson, P. J., & Poulsen, R. C. (2020). Shedding new light on the role of the lens in regulating circadian rhythms. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), ELECTR NETWORK. 1 May - 7 May 2020. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
Other University of Auckland co-authors: Raewyn Poulsen, Paul Donaldson
- Lim, J. C., Grey, A. C., Zahraei, A., & Donaldson, P. J. (2020). Age-dependent changes in glutathione metabolism pathways in the lens: New insights into therapeutic strategies to prevent cataract formation-A review. Clinical & experimental ophthalmology10.1111/ceo.13801
Other University of Auckland co-authors: Paul Donaldson, Gus Grey
- Martis, R. M., Donaldson, P. J., & Lim, J. C. (2020). Corneal opacities in mice exposed to repeated contact procedures during ocular examinations. Clinical & experimental optometry, 103 (3), 307-311. 10.1111/cxo.12934
Other University of Auckland co-authors: Renita Martis, Paul Donaldson
- Martis, R. M., Knight, L. J., Donaldson, P. J., & Lim, J. C. (2020). Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues. Oxidative medicine and cellular longevity, 202010.1155/2020/4594606
Other University of Auckland co-authors: Paul Donaldson, Renita Martis, Luis Knight
- Shivashankar, G., Lim, J. C., & Acosta, M. L. (2020). Proinflammatory cytokines trigger biochemical and neurochemical changes in mouse retinal explants exposed to hyperglycemic conditions. Molecular vision, 26, 277-290.
Other University of Auckland co-authors: Monica Acosta
- Martis, R. M., Donaldson, P. J., Li, B., Middleditch, M., Kallingappa, P. K., & Lim, J. C. (2019). Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance. Histochemistry and cell biology, 152 (4), 293-310. 10.1007/s00418-019-01805-4
Other University of Auckland co-authors: Prasanna Kallingappa, Renita Martis, Paul Donaldson
- Lim, J. C. (2019). Interactions between the lens and ocular humors: identification and visualisation of antioxidant metabolite uptake and efflux pathways in the lens. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA. 28 April - 2 May 2019. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).