Dr Jennifer Miles-Chan
I am an integrative physiologist focused on investigating inter-individual variability in nutritional energetics and the regulation of body composition. My experience covers a diverse range of settings: including a solid background in pre-clinical models and molecular analyses, and experience in more epidemiological-type investigations.
Having completed my PhD (Physiology) at the University of Auckland in 2009, I undertook several years of research within the laboratory of Professor Abdul Dulloo (Faculty of Sciences and Medicine, University of Fribourg, Switzerland), running human translational research projects. Returning to the University of Auckland in mid-2017, after having been awarded a prestigious Sir Charles Hercus Health Research Fellowship from the Health Research Council (2017-2021), I have now established my research lab within the UoA Human Nutrition Unit in Mt Eden.
Research | Current
"Rien ne se perd, rien ne se crée, tout se transforme." (Nothing is lost, nothing is created, everything is transformed) - Antoine Lavoisier, 1789.
Whereas machines require electrical or mechanical energy and plants largely depend on light energy, animals require chemical energy in the form of food nutrients or bodily stores to fuel resting metabolic processes and physical activity. Therefore understanding how the body regulates energy intake, energy stores and energy expenditure in order to maintain equilibrium is key to our understanding of human health and disease.
With this in mind, my research focuses on deciphering inter-individual variability in energy metabolism, and how this relates to inequities in our risk for metabolic disease. This research encompasses several related areas of nutritional energetics and the regulation of body composition, for example:
Teaching | Current
BIOSCI 358 Nutritional Science (course director)
BIOSCI 203 Biochemistry
Taimi Theresa Tuimalealiifano (PhD) Health of Māori and Pacific women: relationships between CREBRF genotype and metabolic resilience. HRC Pacific Health Research PhD Scholarship / University of Auckland
Jack Penhaligan (PhD) Enhancing postprandial thermogenesis & lipid oxidation for the prevention of Type 2 Diabetes. University of Auckland Doctoral Scholarship / University of Auckland
Julia Cree (PhD) Deciphering disparity in obesity: the influence of ethnicity and sex hormones on macronutrient metabolism. Lottery Health Research PhD Scholarship / University of Auckland
Terry O'Donnell (PhD) Impact of environmental conditions on energy balance. Co-supervisor / University of Otago.
Jo Slater (PhD) The gut microbiome - new pathways to obesity prevention and metabolic health, a focus on dietary intake, sleep and physical activity. Co-supervisor / Massey University
Recently Completed Students
Maharani Retna Duhita (PhD) Effect of menstrual cycle phase and oral contraceptive use on dietary protein-induced thermogenesis. Swiss Government Excellence Scholarship / University of Fribourg
Madison Rich (MSc) Popping Pills: The combined oral contraceptive pill and its acute effects on glucose metabolism, cardiometabolic health, appetite, and satiety / University of Auckland
Sophie L'Estrange (MSc) Effect of Oral Contraceptive Pill Use and Habitual Dietary Protein Intake on Glycaemia: A Pilot Study / University of Auckland
2017 - 2021 Sir Charles Hercus Health Research Fellowship, Health Research Council, New Zealand
- Associate Investigator, Metabolic Health PRP, High Value Nutrition, National Science Challenge
- Associate Editor, Obesity Section, Frontiers in Endocrinology
- Member & Webmaster, International Organising Committee, Recent Advances and Controversies in the Measurement of Energy Metabolism (RACMEM)
- Local Organiser & Webmaster, 12th International Symposium on In Vivo Body Composition Studies
- Member, Postgraduate Committee, School of Biological Sciences
Areas of expertise
Thermogenesis, nutritional energetics and body composition regulation
Selected publications and creative works (Research Outputs)
- Calonne, J., Isacco, L., Miles-Chan, J., Arsenijevic, D., Montani, J.-P., Guillet, C., ... Dulloo, A. G. (2019). Reduced Skeletal Muscle Protein Turnover and Thyroid Hormone Metabolism in Adaptive Thermogenesis That Facilitates Body Fat Recovery During Weight Regain. FRONTIERS IN ENDOCRINOLOGY, 1010.3389/fendo.2019.00119
- Isacco, L., & Miles-Chan, J. L. (2018). Gender-specific considerations in physical activity, thermogenesis and fat oxidation: implications for obesity management. Obesity reviews : an official journal of the International Association for the Study of Obesity, 19 Suppl 1, 73-83. 10.1111/obr.12779
- Dulloo, A. G., Miles-Chan, J., Schutz, Y., & Montani, J.-P. (2018). Targeting lifestyle energy expenditure in the management of obesity and health: from biology to built environment. Obesity reviews : an official journal of the International Association for the Study of Obesity, 19 Suppl 1, 3-7. 10.1111/obr.12786
- Monnard, C. R., Fares, E.-J., Calonne, J., Miles-Chan, J. L., Montani, J.-P., Durrer, D., ... Dulloo, A. G. (2017). Issues in continuous 24-h core body temperature monitoring in humans using an ingestible capsule telemetric sensor. Frontiers in Endocrinology, 8.10.3389/fendo.2017.00130
- Fares, E.-J., Isacco, L., Monnard, C. R., Miles-Chan, J. L., Montani, J.-P., Schutz, Y., & Dulloo, A. G. (2017). Reliability of low-power cycling efficiency in energy expenditure phenotyping of inactive men and women. Physiological Reports, 5 (9).10.14814/phy2.13233
- Miles-Chan, J. L., Fares, E.-J., Berkachy, R., Jacquet, P., Isacco, L., Schutz, Y., ... Dulloo, A. G. (2017). Standing economy: Does the heterogeneity in the energy cost of posture maintenance reside in differential patterns of spontaneous weight-shifting?. European Journal of Applied Physiology, 117 (4), 795-807. 10.1007/s00421-017-3563-7
- Dulloo, A. G., Jacquet, J., Miles-Chan, J. L., & Schutz, Y. (2017). Passive and active roles of fat-free mass in the control of energy intake and body composition regulation. European journal of clinical nutrition, 71 (3), 353-357. 10.1038/ejcn.2016.256
- Dulloo, A. G., Miles-Chan, J. L., & Montani, J.-P. (2017). Nutrition, movement and sleep behaviours: their interactions in pathways to obesity and cardiometabolic diseases. Obesity reviews : an official journal of the International Association for the Study of Obesity, 18 Suppl 1, 3-6. 10.1111/obr.12513