Dr Sarah-Jane Guild
PhD (Physiology and Electrical & Electronic Engineering), ME (Engineering Science)
My interest in physiology and engineering has developed into my two complementary current positions (0.5 FTE each) as a Senior Research Fellow in the Department of Physiology and Chief Scientific Officer at Kaha Sciences Ltd. Kaha Sciences specialises in small animal telemetry and sells a wireless telemetry system developed in our laboratory and commercialised in 2004.
With a background in physiology and engineering, my university research involves the collection and analysis of physiological data from animal models in both control and disease states. My current research focuses on the interactions between arterial pressure and intracranial pressure in normal and hydrocephalus (raised intracranial pressure) animal models. I have developed techniques to chronically record intracranial pressure in both rats and sheep which allows us to take advantage of the benefits of working with both small and large animals in our studies.
This recent focus on intracranial pressure has grown from a collaboration with the Implantable Devices Group at the Auckland Bioengineering Institute to develop a fully implantable clinical device to allow the chronic measurement of intracranial pressure in patients with hydrocephalus. We are now also applying similar technologies to the development of an implantable light source for optogenetics therapies and are exploring its application in small and large animal models.
In both my university research and commercial work, I have developed an international reputation in the field of chronic recordings using telemetry. I have visited and provided surgical training for researchers in several major pharmaceutical companies, universities and the FDA. Both my PhD and Master of Engineering degrees were cross discipline, allowing me to take the analytical skills of my engineering background and apply them to the challenging area of physiology.
I believe my two roles have complemented each other well with my scientific background being invaluable in my commercial role and my interactions with customers and the more controlled design process enriching my academic research and student supervision.
Research | Current
- Intracranial pressure
- Traumatic Brain Injury
Teaching | Current
MEDSCI 733 - Advanced methods in Cellular Physiology
Selected publications and creative works (Research Outputs)
- Au, S. L. C., Chen, F.-Y. B., Budgett, D., Malpas, S. C., Guild, S.-J., & McCormick, D. (2019). Injection Molded Liquid Crystal Polymer Package for Chronic Active Implantable Devices with Application to an Optogenetic Stimulator. IEEE transactions on bio-medical engineering10.1109/tbme.2019.2936577
Other University of Auckland co-authors: David Budgett, Daniel McCormick
- Guild, S.-J., Saxena, U. A., McBryde, F. D., Malpas, S. C., & Ramchandra, R. (2018). Intracranial pressure influences the level of sympathetic tone. American journal of physiology. Regulatory, integrative and comparative physiology, 315 (5), R1049-R1053. 10.1152/ajpregu.00183.2018
Other University of Auckland co-authors: Fiona McBryde, Rohit Ramchandra, Simon Malpas
- Pinkham, M. I., Loftus, M. T., Amirapu, S., Guild, S.-J., Quill, G., Woodward, W. R., ... Barrett, C. J. (2017). Renal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 312 (3), R368-R379. 10.1152/ajpregu.00313.2016
Other University of Auckland co-authors: Satya Amirapu, Carolyn Barrett
- Han, J.-C., Guild, S.-J., Pham, T., Nisbet, L., Tran, K., Taberner, A. J., & Loiselle, D. S. (2017). Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure. Frontiers in physiology, 810.3389/fphys.2017.01115
Other University of Auckland co-authors: Denis Loiselle, June-Chiew Han, Kenneth Tran, Andrew Taberner, Toan Pham
- Guild, S. J., McBryde, F. D., & Malpas, S. C. (2015). Recording of intracranial pressure in conscious rats via telemetry. Journal of Applied Physiology, 119 (5), 576-581. 10.1152/japplphysiol.00165.2015
Other University of Auckland co-authors: Simon Malpas, Fiona McBryde
- Clark, T. M., Malpas, S. C., McCormick, D., Guild, S.-J., & Budgett, D. M. (2015). New multimodal data obtained in-vivo from a single ultra-miniature transducer. Biomed Microdevices, 17 (4)10.1007/s10544-015-9984-3
Other University of Auckland co-authors: Daniel McCormick, Simon Malpas, David Budgett
- Pinkham, M. I., Whalley, G. A., Guild, S.-J., Malpas, S. C., & Barrett, C. J. (2015). Arterial baroreceptor reflex control of renal sympathetic nerve activity following chronic myocardial infarction in male, female, and ovariectomized female rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 309 (2), R169-R178. 10.1152/ajpregu.00026.2015
Other University of Auckland co-authors: Carolyn Barrett, Simon Malpas
- Stehlin, E., Malpas, S. C., Budgett, D. M., Barrett, C. J., McCormick, D., Whalley, G., ... Guild, S.-J. (2013). Chronic measurement of left ventricular pressure in freely moving rats. J Appl Physiol (1985), 115 (11), 1672-1682. 10.1152/japplphysiol.00683.2013
Other University of Auckland co-authors: Carolyn Barrett, Simon Malpas, David Budgett, Daniel McCormick
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