Miss Zahra Aghababaie

Master of Science in Biotechnology

Profile Image
Doctoral Candidate - Doctor of Philosophy

Biography

Zahra received a Bachelor of Science in Chemical Engineering from the Isfahan University of Technology. She completed her Master of Science in Biotechnology from the Sharif University of Technology. The master research focused on “Experimental study of biocompatibility of silver-based nanoparticles and their use in tissue engineering”. After her master degree, she continued her research at the Sharif University of Technology as a research assistance various projects, such as “the study of hydrogels and microparticles with the ability to release drugs”.

In 2018, Zahra started her PhD in Bioengineering. Now, she is a member of the Gastrointestinal group in the Auckland Bioengineering Institute.

Research | Current

Thesis:  Targeted ablation therapy for the treatment of gastrointestinal dysrhythmias  

This project seeks to develop gastric ablation as a novel method for disrupting gastric dysrhythmias to provide a new therapeutic strategy for GI motility disorders. This project aims to investigate 3 key hypotheses: 1) Radio-frequency (RF) ablation parameters can be optimized to ablate targeted sections of gastric smooth muscle without causing mucosal damage, but still achieving the desired localized electrical conduction block. 2) Gastric ablation can be targeted to sites of gastric dysrhythmia, identified by high-resolution (HR) electrical mapping, to abolish the dysrhythmic conduction mechanisms. 3) Gastric ablation can create persistent lesions through the smooth muscle layers of the GI wall, resulting in a sustained electrical block of slow wave conduction after a two-week healing period, without causing perforation of the gut.

Research group:

Gastrointestinal System Group, Auckland Bioengineering Institute

Supervisors:

Dr Tim Angeli

Professor  Leo Cheng

Dr Nirachan Paskaranandavadivel

Areas of expertise

Proficient in Wet-Lab expertise, cell culture techniques and microbial culture skills, Fabrication of drug loaded scaffolds and Histology.

Selected publications and creative works (Research Outputs):

  • Aghababaie, Z., Jamart, K., Chan, C.H.A., Amirapu, S., Cheng, L.K., Paskaranandavadivel, N., Avci, R. and Angeli, T.R., 2020, July. A V-Net Based Deep Learning Model for Segmentation and Classification of Histological Images of Gastric Ablation. In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 1436-1439). IEEE. doi: 10.1109/EMBC44109.2020.9176220 .
  • Chan, C.H.A., Aghababaie, Z., Paskaranandavadivel, N., Cheng, L.K., Avci, R. and Angeli, T.R., 2020, July. Trace Mapping: A New Visualization Technique for Analyzing Gastrointestinal High-Resolution Electrical Mapping Data. In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 5212-5215). IEEE. doi:10.1109/EMBC44109.2020.9175476.
  • Sayat, M., Aghababaie, Z., Cheng, L.K., Paskaranandavadivel, N., Avci, R., Rickus, J., Ruha, W. and Angeli, T.R., 2020, July. Transmural Temperature Monitoring to Quantify Thermal Conduction And Lesion Formation During Gastric Ablation, an Emerging Therapy for Gastric Dysrhythmias. In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 5259-5262). IEEE. doi: 10.1109/EMBC44109.2020.9176026.
  • Aghababaie, Z., Chan, C.H.A., Paskaranandavadivel, N., Beyder, A., Farrugia, G., Asirvatham, S., O’Grady, G., Cheng, L.K. and Angeli, T.R., 2019, July. Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 170-173). IEEE. doi: 10.1109/EMBC.2019.8856406.
  • Chan, C.H.A., Aghababaie, Z., Paskaranandavadivel, N., Cheng, L.K. and Angeli, T.R., 2019, July. Methods for Visualization of Gastric Endoscopic Mapping Data From Three-Dimensional, Non-Uniform Electrode Arrays. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 2222-2225). IEEE. doi: 10.1109/EMBC.2019.8857158.
  • Shamloo, A., Sarmadi, M., Aghababaie, Z. and Vossoughi, M., 2018. Accelerated full-thickness wound healing via sustained bFGF delivery based on a PVA/chitosan/gelatin hydrogel incorporating PCL microspheres. International journal of pharmaceutics537(1-2), pp.278-289. doi: 10.1016/j.ijpharm.2017.12.045
  • Mohseni, M., Shamloo, A., Aghababaie, Z., Afjoul, H., Abdi, S., Moravvej, H. and Vossoughi, M., 2019. A comparative study of wound dressings loaded with silver sulfadiazine and silver nanoparticles: In vitro and in vivo evaluation. International Journal of Pharmaceutics564, pp.350-358. doi: 10.1016/j.ijpharm.2019.04.068
  • Mohseni, M., Shamloo, A., Aghababaei, Z., Vossoughi, M. and Moravvej, H., 2016. Antimicrobial wound dressing containing silver sulfadiazine with high biocompatibility: in vitro study. Artificial organs40(8), pp.765-773. doi: 10.1111/aor.12682

 

Conferences

  • Aghababaie, Z., Chan, C.H.A., Paskaranandavadivel, N., Beyder, A., Farrugia, G., Asirvatham, S., O'Grady, G., Cheng, L.K. and Angeli, T.R., 2020, March. Targeted gastric ablation as a method for modulating gastric slow wave pacemakers. In NEUROGASTROENTEROLOGY AND MOTILITY (Vol. 32). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY.
  • Chan, C.H.A., Aghababaie, Z., Paskaranandavadivel, N., Cheng, L.K. and Angeli, T.R., 2019. Mo1620–Distension-Induced Gastric Slow Wave Dysrhythmias Defined by High-Resolution Electrical Mapping in the Pig. Gastroenterology156(6), pp.S-805.

 

Contact details

Primary office location

AUCKLAND BIOENGINEERING HOUSE - Bldg 439
Level 8, Room 801
70 SYMONDS ST
GRAFTON
AUCKLAND 1010
New Zealand