Dr Adrian Blaser

MSc PhD Bern

Biography

Adrian Blaser obtained his Masters and PhD in Chemistry from the University of Bern, Switzerland. After a postdoctoral position with Professor Margaret Brimble at the University of Auckland, Adrian was appointed as a Research Fellow in the Centre designing and developing novel drugs for cancer treatment.

Research interests

Research | Current

After 3 years on a variety of projects ranging from developing a backup compound for a drug in clinical trial phase I on erbB2 Inhibition to developing a new Antibacterial agent I am now working on a project in collaboration with the Global Alliance of Tuberculosis (GATB) to develop a backup drug of PA-824, a new antibacterial agent against Mycobacterium tuberculosis. The aim of the project is to develop an efficient drug with a novel mode of action that avoids cross-resistance with existing drugs, and will simultaneously address many pressing current medical needs.

I am now in charge of the NMR facility at the ACSRC.

Distinctions/Honours

  • Appointed Justice of the Peace for New Zealand, 12 November 2014
  • Appointed Honorary Consul for Switzerland in Auckland, 1 January 2019

Committees/Professional groups/Services

Justice of the Peace service at Grafton Campus (by appointment) and City Drop In Sessions

2021-   Senate as FMHS delegate

2021-   Board of Graduate Studies as sub-professorial delegate

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Choi, P. J., Conole, D., Sutherland, H. S., Blaser, A., Tong, A. S. T., Cooper, C. B., ... Denny, W. A. (2020). Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogueof Bedaquiline. Molecules (Basel, Switzerland), 25 (6).10.3390/molecules25061423
    Other University of Auckland co-authors: Peter Choi, Sir Bill Denny, Brian Palmer
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Palmer, B. D. (2020). Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology. Bioorganic & medicinal chemistry, 28 (1)10.1016/j.bmc.2019.115213
    Other University of Auckland co-authors: Peter Choi, Sir Bill Denny, Brian Palmer
  • Blaser, A., Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline. Bioorganic & medicinal chemistry, 27 (7), 1283-1291. 10.1016/j.bmc.2019.02.025
    Other University of Auckland co-authors: Sir Bill Denny, Peter Choi, Brian Palmer
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorganic & medicinal chemistry, 27 (7), 1292-1307. 10.1016/j.bmc.2019.02.026
    Other University of Auckland co-authors: Sir Bill Denny, Peter Choi, Brian Palmer
  • Choi, P., Sutherland, H., Tong, A., Conole, D., Blaser, A., Cooper, C., ... Palmer, B. (31/3/2019). Next-generation bedaquiline for the treatment of tuberculosis. Poster presented at 257th National Meeting of the American-Chemical-Society (ACS), Orlando, FL. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
    Other University of Auckland co-authors: Peter Choi, Sir Bill Denny, Brian Palmer
  • Black, S. L., O'Connor PD, Boyd, M., Blaser, A., & Kendall, J. D. (2018). Synthesis and 1 H, 13 C and 15 N NMR characterisation of substituted Pyrazolo[4,3- c ]quinolines and related compounds. Tetrahedron, 74 (22), 2797-2806. 10.1016/j.tet.2018.04.061
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Blaser, A., Franzblau, S. G., ... Denny, W. A. (2018). Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles. Bioorganic & medicinal chemistry, 26 (8), 1797-1809. 10.1016/j.bmc.2018.02.026
    Other University of Auckland co-authors: Peter Choi, Sir Bill Denny, Brian Palmer, Hamish Sutherland
  • Thompson, A. M., O'Connor PD, Marshall, A. J., Blaser, A., Yardley, V., Maes, L., ... Chatelain, E. (2018). Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis. Journal of medicinal chemistry, 61 (6), 2329-2352. 10.1021/acs.jmedchem.7b01581
    Other University of Auckland co-authors: Andrew Thompson, Sir Bill Denny

Identifiers

Contact details

Alternative contact

DDI +64 9 923 8228

Mobile +64 21 232 7998

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 125
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links