Dr Adrian Blaser

MSc PhD Bern

Biography

Adrian Blaser obtained his Masters and PhD in Chemistry from the University of Bern, Switzerland. After a postdoctoral position with Professor Margaret Brimble at the University of Auckland, Adrian was appointed as a Research Fellow in the Centre designing and developing novel drugs for cancer treatment.

Research interests

Research | Current

After 3 years on a variety of projects ranging from developing a backup compound for a drug in clinical trial phase I on erbB2 Inhibition to developing a new Antibacterial agent I am now working on a project in collaboration with the Global Alliance of Tuberculosis (GATB) to develop a backup drug of PA-824, a new antibacterial agent against Mycobacterium tuberculosis. The aim of the project is to develop an efficient drug with a novel mode of action that avoids cross-resistance with existing drugs, and will simultaneously address many pressing current medical needs.

I am now in charge of the NMR facility at the ACSRC.

Selected publications and creative works (Research Outputs)

  • Choi, P. J., Sutherland, H. S., Tong, A. S. T., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Motte, M. (2017). Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units. Bioorganic & medicinal chemistry letters10.1016/j.bmcl.2017.10.042
    Other University of Auckland co-authors: Peter Choi, Bill Denny, Brian Palmer
  • Tong, A., Choi, P., Blaser, A., Sutherland, H. S., Tsang, S., Guillemont, J., ... Broeck, W. V. D. (2017). 6-Cyano analogues of bedaquiline as less lipophilic and potentially safer diarylquinolines for tuberculosis. ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.7b00196
    Other University of Auckland co-authors: Peter Choi, Bill Denny, Brian Palmer
  • Thompson, A. M., Blaser, A., Palmer, B. D., Anderson, R. F., Shinde, S. S., Launay, D., ... Wan, B. (2017). 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases. Bioorganic & medicinal chemistry letters, 27 (11), 2583-2589. 10.1016/j.bmcl.2017.03.069
    Other University of Auckland co-authors: Brian Palmer, Andrew Thompson, Bob Anderson, Bill Denny
  • Smaill, J. B., Gonzales, A. J., Spicer, J. A., Lee, H., Reed, J. E., Sexton, K., ... Blaser, A. (2016). Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4- d ]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family. Journal of Medicinal Chemistry, 59 (17), 8103-8124. 10.1021/acs.jmedchem.6b00883
    URL: http://hdl.handle.net/2292/32487
    Other University of Auckland co-authors: Jeffrey Smaill, Bill Denny, Andrew Thompson, Julie Spicer, Brian Palmer
  • Thompson, A. M., O'Connor PD, Blaser, A., Yardley, V., Maes, L., Gupta, S., ... Wan, B. (2016). Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. Journal of medicinal chemistry, 59 (6), 2530-2550. 10.1021/acs.jmedchem.5b01699
    URL: http://hdl.handle.net/2292/30023
    Other University of Auckland co-authors: Bill Denny, Andrew Thompson
  • Thompson, A. M., Blaser, A., Palmer, B. D., Franzblau, S. G., Wan, B., Wang, Y., ... Denny, W. A. (2015). Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy. Bioorganic & Medicinal Chemistry Letters, 25 (18), 3804-3809. 10.1016/j.bmcl.2015.07.084
    Other University of Auckland co-authors: Bill Denny, Andrew Thompson, Brian Palmer
  • Palmer, B. D., Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., ... Thompson, A. M. (2015). Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824). Journal of medicinal chemistry, 58 (7), 3036-3059. 10.1021/jm501608q
    Other University of Auckland co-authors: Bill Denny, Andrew Thompson, Brian Palmer, Hamish Sutherland
  • Thompson, A. M., Denny, W. A., Blaser, A., & Ma, Z.. Nitroimidazooxazine and nitroimidazoooxazole analogues and their uses. US 8293734 B2 Related URL.
    Other University of Auckland co-authors: Andrew Thompson, Bill Denny

Identifiers

Contact details

Alternative contact

DDI +64 9 923 8228

Mobile +64 21 232 7998

Primary location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 125
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

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