Dr Anna Claire Giddens

Research Fellow

In: Auckland Cancer Society Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

Research group:

Selective Inhibitors of Phosphoinositide 3-Kinases (PI3Ks)

Selected publications and creative works (Research Outputs)

Giddens, A. C., Gamage, S. A., Kendall, J. D., Lee, W.-J., Baguley, B. C., Buchanan, C. M., ... Denny, W. A. (2019). Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic & medicinal chemistry, 27 (8), 1529-1545. 10.1016/j.bmc.2019.02.050
Other University of Auckland co-authors: James Dickson, Swarna Gamage, Christina Buchanan, Woo Lee, Stephen Jamieson, Bill Denny, Gordon Rewcastle
Gamage, S. A., Giddens, A. C., Tsang, K. Y., Flanagan, J. U., Kendall, J. D., Lee, W.-J., ... Shepherd, P. R. (2017). Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic and Medicinal Chemistry, 25 (20), 5859-5874. 10.1016/j.bmc.2017.09.025
URL: http://hdl.handle.net/2292/41240
Other University of Auckland co-authors: Gordon Rewcastle, Swarna Gamage, Bill Denny, Jack Flanagan, Christina Buchanan, Stephen Jamieson, Woo Lee
Rewcastle, G. W., Kolekar, S., Buchanan, C. M., Gamage, S. A., Giddens, A. C., Tsang, K. Y., ... Smith, G. C. (2017). Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors. Oncotarget, 8 (29), 47725-47740. 10.18632/oncotarget.17730
URL: http://hdl.handle.net/2292/34774
Other University of Auckland co-authors: Peter Shepherd, Gordon Rewcastle, Christina Buchanan, Swarna Gamage, Bill Denny, Stephen Jamieson, Woo Lee
Kendall, J., Giddens, A., Tsang, K., Marshall, E., Lill, C., Lee, W.-J., ... Yu, S. (2017). Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters, 27 (2), 187-190. 10.1016/j.bmcl.2016.11.078
URL: http://hdl.handle.net/2292/34181
Other University of Auckland co-authors: Peter Shepherd, Bill Denny, Christina Buchanan, Gordon Rewcastle, Stephen Jamieson, Woo Lee
Giddens, A. C., Lee, H. H., Lu, G.-L., Miller, C. K., Guo, J., Lewis Phillips, G. D., ... Tercel, M. (2016). Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody-drug conjugates. Bioorganic & Medicinal Chemistry, 24 (22), 6075-6081. 10.1016/j.bmc.2016.09.068
Other University of Auckland co-authors: Moana Tercel, Leon Lu, Ho Lee, Christian Miller
Lu, G., Tercel, M., Giddens, A., Lee, H., Bonnet, M., Denny, W., ... Stabenb, L. R. (2016). Arming antibodies with DNA cross-linking agents derived from the duocarmycins. Paper presented at The 24th International Symposium on Medicinal Chemistry (EFMC-ISMC-2016), Manchester, UK. 28 August - 1 September 2016. EFMC International Symposium on Medicinal Chemistry Book of Abstracts. Related URL.
URL: http://hdl.handle.net/2292/32939
Other University of Auckland co-authors: Leon Lu, Moana Tercel, Bill Denny
Rewcastle, G. W., Giddens, A. C., Flanagan, J. U., Gamage, S. A., Tsang, K. Y., Kendall, J. D., ... O'Farrell M (2015). Design and discovery of PWT33597 (VDC-597), a dual inhibitor of PI3-kinase alpha and mTOR. Paper presented at 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem), Honolulu, Hawaii, USA. 15 December - 20 December 2015.
Other University of Auckland co-authors: Gordon Rewcastle, Jack Flanagan, Swarna Gamage, Christina Buchanan, Stephen Jamieson, Bill Denny, Peter Shepherd
Giddens, A., Bonnet, M., Lee, H., Lu, G. L., Miller, C. K., Tercel, M., ... Safina, B. (16/12/2015). Potent DNA crosslinking cytotoxins as novel payloads for ADCs. Poster presented at Pacifichem 2015, Honolulu, Hawaii, USA.
Other University of Auckland co-authors: Ho Lee, Leon Lu, Christian Miller, Gordon Rewcastle, Moana Tercel, Bill Denny