Dr Andrea Kwakowsky

Biography

Andrea completed her PhD at Eötvös Loránd University, Budapest, carried out her research on gamma-aminobutyric acid (GABA) signalling during development at the Institute of Experimental Medicine. Then she took up a Postdoctoral Fellowship in the Department of Physiology at the University of Otago, where she studied the effect of oestrogen on signalling pathways in gonadotrophin releasing hormone (GnRH) and cholinergic neurons. From 2012 she has been a Research Fellow at Otago University working on the use of activators of nongenotropic estrogen-like signalling (ANGELS) as a potential treatment for Alzheimer`s disease and she has started to study the role of oestrogen and GABA signalling during aging and in Alzheimer`s disease. The project for her Aotearoa Foundation Neuroscience Fellowship involves identifying components of GABA type A receptor signalling that are affected by the beta-amyloid peptides in the Alzheimer’s diseased brain. Andrea is characterising the mechanism and role of oestrogen and GABA signalling using interdisciplinary approaches, combining molecular, physiological and anatomical techniques. She is studying the molecular components, the molecular and cellular architecture of these multifunctional signalling systems and aims to elucidate their physiological role in the aging and Alzheimer`s disease brain.

Areas of expertise

Neuroscience

Alzheimer`s disease

Human neurodegenerative diseases

Gamma-aminobutyric acid (GABA) signalling

Estrogen signalling

Neurotrophin signalling

Neuroprotection

Selected publications and creative works (Research Outputs)

  • Yeung, J. H. Y., Calvo-Flores Guzmán B, Palpagama, T. H., Ethiraj, J., Zhai, Y., Tate, W. P., ... Kwakowsky, A. (2020). Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus. Journal of neurochemistry10.1111/jnc.15099
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel
  • Govindpani, K., Vinnakota, C., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2020). Vascular dysfunction in Alzheimer's disease: a biomarker of disease progression and a potential therapeutic target. NEURAL REGENERATION RESEARCH, 15 (6), 1030-1032. 10.4103/1673-5374.270306
    URL: http://hdl.handle.net/2292/49948
    Other University of Auckland co-authors: Henry Waldvogel, Karan Govindpani, Richard Faull
  • Vinnakota, C., Govindpani, K., Tate, W. P., Peppercorn, K., Anekal, P. V., Waldvogel, H. J., ... Kwakowsky, A. (2020). An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures. International journal of molecular sciences, 21 (9).10.3390/ijms21093284
    Other University of Auckland co-authors: Karan Govindpani, Henry Waldvogel, Richard Faull
  • Calvo-Flores Guzmán B, Kim, S., Chawdhary, B., Peppercorn, K., Tate, W. P., Waldvogel, H. J., ... Kwakowsky, A. (2020). Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells. Molecules (Basel, Switzerland), 25 (3).10.3390/molecules25030693
    Other University of Auckland co-authors: Henry Waldvogel, Richard Faull
  • Yeung, J. H. Y., Palpagama, T. H., Tate, W. P., Peppercorn, K., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2020). The Acute Effects of Amyloid-Beta(1-42) on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus. Frontiers in Neuroscience, 1310.3389/fnins.2019.01427
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel
  • Palpagama, T. H., Sagniez, M., Kim, S., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2019). GABAA Receptors Are Well Preserved in the Hippocampus of Aged Mice. eNeuro, 6 (4).10.1523/eneuro.0496-18.2019
    URL: http://hdl.handle.net/2292/49147
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel
  • Govindpani, K., McNamara, L. G., Smith, N. R., Vinnakota, C., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2019). Vascular Dysfunction in Alzheimer's Disease: A Prelude to the Pathological Process or a Consequence of It?. Journal of clinical medicine, 8 (5).10.3390/jcm8050651
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel, Karan Govindpani
  • Pandya, M., Palpagama, T. H., Turner, C., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2019). Sex- and age-related changes in GABA signaling components in the human cortex. Biology of sex differences, 10 (1)10.1186/s13293-018-0214-6
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel

Identifiers

Contact details

Primary office location

M&HS BUILDING 503 - Bldg 503
Level 5, Room 501
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

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