Dr Andrea Kwakowsky

Biography

Andrea completed her PhD at Eötvös Loránd University, Budapest, carried out her research on gamma-aminobutyric acid (GABA) signalling during development at the Institute of Experimental Medicine. Then she took up a Postdoctoral Fellowship in the Department of Physiology at the University of Otago, where she studied the effect of oestrogen on signalling pathways in gonadotrophin releasing hormone (GnRH) and cholinergic neurons. From 2012 she has been a Research Fellow at Otago University working on the use of activators of nongenotropic estrogen-like signalling (ANGELS) as a potential treatment for Alzheimer’s disease and she has started to study the role of oestrogen and GABA signalling during aging and in Alzheimer’s disease. The project for her Aotearoa Foundation Neuroscience Fellowship (2015-2018) at the Centre for Brain Research, University of Auckland involved identifying components of GABA type A receptor signalling that are affected by the beta-amyloid peptides in the Alzheimer's diseased brain. Most recently she was awarded the Alzheimer’s New Zealand, the Freemasons New Zealand and the Alzheimer’s New Zealand Charitable Trust Senior Research Fellowships. 

Andrea is characterising the mechanism and role of oestrogen, GABA and glutamate signalling using interdisciplinary approaches, combining molecular, physiological and anatomical techniques. She is studying the molecular components, the molecular and cellular architecture of these multifunctional signalling systems and aims to elucidate their physiological role in the aging and Alzheimer's disease brain. Other studies in her lab involve identification of new  drug targets and drug testing, development of imaging tools, and studying neuroinflammation in Alzheimer's, Huntington's disease and Multiple sclerosis. 

Teaching | Current

Advanced Neuroscience: Neuropharmacology MEDSCI 717

Reproduction, Development and Ageing MBCHB 321

Medical Humanities, Research Option MBCHB 311

Project Design in Biomedical Science MEDSCI 744

Special Studies in Medical Sciences MEDSCI 701

Postgraduate supervision

Enquiries from prospective graduate students and postdocs are welcome

Current Students

PhD: Thulani Palpagama, Soo Hyun Kim, Julia Newland, Delshad Kalantary, Janelle Chong

MSc: Patty Lam, Vincent Fegan, Antonio de Souza, Isabella Lavas, Kim Rodan Burgos, Moradeke Marvelous Adesina 

BSc (Honours) Biomedical Science: Oliver Wood

BSc (Honours) Medical Science: Mackenzie (Molly) Ferguson 

A list of all students supervised to successful completion

PhD: Karan Govindpani, Beatriz Calvo-Flores Guzmán

MSc: Michael Milne, Malanie Sagniez, Samuel Dodd, Madhavi Pandya, Chitra Vinnakota, Jayarjun Ethirjan, Bhavya Chawdhary      

BSc (Honours): Thulani Palpagama, Tessa Fuhrer, Josh Walby, Phoebe Anscombe, Aimee Mills, Laura McNamara  

BSc (Honours) Medical Science: Jason Yeung

Summer Research Scholars: Christopher Adam Haug, Thulani Palpagama, Tessa Fuhrer, Caitlin Ashcroft, Sarah Waters, Jason Yeung, Jayarjun Ethirjan, Smriti Gupta, Vyoma Mistry, Bhavya Chawdhary, Ying Zhai, Laura McNamara, Nicholas Smith, Julia Newland, Erik Rajwer, Matthew Adye, Kevin M. Griffee, Connor Kennedy, Molly Ferguson, Emily Meyer, Emma Bultitude, Stephen Ke                  

Areas of expertise

Neuroscience, Alzheimer's and Huntington's disease, Human neurodegenerative diseases, Gamma-aminobutyric acid (GABA) and glutamate signalling, Estrogen signalling, Neurotrophin signalling, Neuroprotection, Neuroinflmmation

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Yeung, J. H. Y., Calvo-Flores Guzmán B, Palpagama, T. H., Ethiraj, J., Zhai, Y., Tate, W. P., ... Kwakowsky, A. (2020). Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus. Journal of neurochemistry, 155 (1), 62-80. 10.1111/jnc.15099
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel
  • Govindpani, K., Vinnakota, C., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2020). Vascular dysfunction in Alzheimer's disease: a biomarker of disease progression and a potential therapeutic target. NEURAL REGENERATION RESEARCH, 15 (6), 1030-1032. 10.4103/1673-5374.270306
    Other University of Auckland co-authors: Henry Waldvogel, Richard Faull
  • Vinnakota, C., Govindpani, K., Tate, W. P., Peppercorn, K., Anekal, P. V., Waldvogel, H. J., ... Kwakowsky, A. (2020). An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures. International journal of molecular sciences, 21 (9).10.3390/ijms21093284
    Other University of Auckland co-authors: Henry Waldvogel, Richard Faull
  • Calvo-Flores Guzmán B, Kim, S., Chawdhary, B., Peppercorn, K., Tate, W. P., Waldvogel, H. J., ... Kwakowsky, A. (2020). Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells. Molecules (Basel, Switzerland), 25 (3).10.3390/molecules25030693
    Other University of Auckland co-authors: Henry Waldvogel, Richard Faull
  • Yeung, J. H. Y., Palpagama, T. H., Tate, W. P., Peppercorn, K., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2020). The Acute Effects of Amyloid-Beta(1-42) on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus. Frontiers in Neuroscience, 1310.3389/fnins.2019.01427
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel
  • Palpagama, T. H., Sagniez, M., Kim, S., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2019). GABAA Receptors Are Well Preserved in the Hippocampus of Aged Mice. eNeuro, 6 (4).10.1523/eneuro.0496-18.2019
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel
  • Govindpani, K., McNamara, L. G., Smith, N. R., Vinnakota, C., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2019). Vascular Dysfunction in Alzheimer's Disease: A Prelude to the Pathological Process or a Consequence of It?. Journal of clinical medicine, 8 (5).10.3390/jcm8050651
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel
  • Pandya, M., Palpagama, T. H., Turner, C., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2019). Sex- and age-related changes in GABA signaling components in the human cortex. Biology of sex differences, 10 (1)10.1186/s13293-018-0214-6
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel

Identifiers

Contact details

Primary office location

M&HS BUILDING 503 - Bldg 503
Level 5, Room 501
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

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