Dr Andrea Kwakowsky

Biography

Andrea completed her PhD at Eötvös Loránd University, Budapest, carried out her research on gamma-aminobutyric acid (GABA) signalling during development at the Institute of Experimental Medicine. Then she took up a Postdoctoral Fellowship in the Department of Physiology at the University of Otago, where she studied the effect of oestrogen on signalling pathways in gonadotrophin releasing hormone (GnRH) and cholinergic neurons. From 2012 she has been a Research Fellow at Otago University working on the use of activators of nongenotropic estrogen-like signalling (ANGELS) as a potential treatment for Alzheimer`s disease and she has started to study the role of oestrogen and GABA signalling during aging and in Alzheimer`s disease. The project for her Aotearoa Foundation Neuroscience Fellowship involves identifying components of GABA type A receptor signalling that are affected by the beta-amyloid peptides in the Alzheimer’s diseased brain. Andrea is characterising the mechanism and role of oestrogen and GABA signalling using interdisciplinary approaches, combining molecular, physiological and anatomical techniques. She is studying the molecular components, the molecular and cellular architecture of these multifunctional signalling systems and aims to elucidate their physiological role in the aging and Alzheimer`s disease brain.

Areas of expertise

Neuroscience

Alzheimer`s disease

Human neurodegenerative diseases

Gamma-aminobutyric acid (GABA) signalling

Estrogen signalling

Neurotrophin signalling

Neuroprotection

Selected publications and creative works (Research Outputs)

Identifiers

Contact details

Primary office location

M&HS BUILDING 503 - Bldg 503
Level 5, Room 501
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links