Miss Ashly Jose
Research | Current
My research project is focused on developing and using nonlinear microscopy to study brain cell and network function in Autism spectrum Disorder. Two-photon microscopy is a powerful high-resolution imaging tool using short intense pulses from a passively mode-locked fiber laser for studying neuronal networks in living animals which has imaging power to provide a single cell and even single synapse level detail from hundreds of neurons simultaneously. The existing custom-built two-photon microscope is being transformed into an in vivo imaging system and will be used to examine brain activity in neuronal circuits in vivo.
Specifically, we will determine how sensory neuronal networks are altered in a mouse model of Autism Spectrum Disorder (ASD). ASDs are developmental disorders defined by impaired learning, sensory disorders, communication difficulties, social deficits, and stereotyped behaviors. These deficits are also present in mouse models of ASD, allowing the cellular
changes underlying these behaviors to be examined. By examining brain activity in an ASD mouse model using two-photon imaging we will gain insights into how neuronal network activity and responses to sensory stimuli are altered compared to wild type animals.
Teaching | Current
Physics 91F Lab Demonstration
Physics 92F Lab Demonstration
- 2018 : Visiting Student Fellowship; Raman Research Institute,Bangalore, India
- 2019 : PhD Scholarship from Dodd-Walls Centre for Photonic and Quantum Technologies
Areas of expertise
- Nonlinear Optical Measurements (Z-scan)
- Liquid Phase Pulsed Laser Deposition of Pure solid Targets.
- The Dodd-Walls Centre for Photonic and Quantum Technologies (DWC), New Zealand