Dr Andrew Mark Thompson

BSc(Hons), PhD

Biography

I obtained my PhD in the field of marine natural products chemistry from the University of Canterbury, under the supervision of Drs John Blunt and Murray Munro. I joined the Auckland Cancer Society Research Centre in 1991 and, in partnership with Pfizer Global Research and Development, first investigated inhibitors of various kinases as novel anticancer therapies and then inhibitors of DNA gyrase as potential antibacterial agents. Since 2005, my research has focussed on the development of new drugs for tuberculosis and neglected tropical diseases, in collaboration with the Global Alliance for TB Drug Development and the Drugs for Neglected Diseases initiative. As Project Leader and chemist, I recently designed and synthesized DNDI-0690, a first-in-class drug candidate for visceral leishmaniasis which is now in clinical trials. I am currently an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery.

Research interests

Research | Current

  • Design and synthesis of antitubercular drugs for nanoparticle and microparticle delivery

  • Target-based approaches to drug discovery for tuberculosis

  • Nitroheterocyclic compounds for the treatment of neglected diseases

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Thompson, A. M., O'Connor PD, Marshall, A. J., Francisco, A. F., Kelly, J. M., Riley, J., ... Thompson, R. C. A. (2020). Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy. European Journal of Medicinal Chemistry, 207.10.1016/j.ejmech.2020.112849
    Other University of Auckland co-authors: Bill Denny
  • Thompson, A. M., O'Connor PD, Marshall, A. J., Yardley, V., Maes, L., Launay, D., ... Denny, W. A. (2019). Development of DNDI-0690: A new clinical candidate for visceral leishmaniasis. Paper presented at 7th International Symposium on Current Trends in Drug Discovery Research, Lucknow, India. 20 February - 23 February 2019.
    Other University of Auckland co-authors: Bill Denny
  • Thompson, A. M., & Denny, W. A. (2019). Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis. In K. Chibale (Ed.) (pp. 97-130). ELSEVIER ACADEMIC PRESS INC. 10.1016/bs.armc.2019.05.001
    URL: http://hdl.handle.net/2292/48645
    Other University of Auckland co-authors: Bill Denny
  • Thompson, A. M., O'Connor PD, Marshall, A. J., Blaser, A., Yardley, V., Maes, L., ... Chatelain, E. (2018). Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis. Journal of medicinal chemistry, 61 (6), 2329-2352. 10.1021/acs.jmedchem.7b01581
    Other University of Auckland co-authors: Adrian Blaser, Bill Denny
  • Thompson, A. M., Marshall, A. J., Maes, L., Yarlett, N., Bacchi, C. J., Gaukel, E., ... Chatelain, E. (2018). Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides. Bioorganic & medicinal chemistry letters, 28 (2), 207-213. 10.1016/j.bmcl.2017.10.067
    Other University of Auckland co-authors: Bill Denny
  • Thompson, A. M., Bonnet, M., Lee, H. H., Franzblau, S. G., Wan, B., Wong, G. S., ... Denny, W. A. (2017). Antitubercular nitroimidazoles revisited: Synthesis and activity of the authentic 3-Nitro isomer of pretomanid. ACS Medicinal Chemistry Letters, 8 (12), 1275-1280. 10.1021/acsmedchemlett.7b00356
    Other University of Auckland co-authors: Ho Lee, Bill Denny
  • Bonnet, M., Thompson, A. M., Lee, H. H., Franzblau, S. G., Wan, B., Wong, G. S., ... Denny, W. A. (5/9/2017). Synthesis, characterization and biological activity of the 3-nitro isomer of bioreductive TB drug pretomanid (PA-824). Poster presented at 26th International Society of Heterocyclic Chemistry Congress, Regensburg, Germany.
    Other University of Auckland co-authors: Ho Lee, Bill Denny
  • Thompson, A. M., Blaser, A., Palmer, B. D., Anderson, R. F., Shinde, S. S., Launay, D., ... Wan, B. (2017). 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases. Bioorganic and Medicinal Chemistry Letters, 27 (11), 2583-2589. 10.1016/j.bmcl.2017.03.069
    Other University of Auckland co-authors: Brian Palmer, Adrian Blaser, Bob Anderson, Bill Denny

Identifiers

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 117
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links