Dist Prof Bruce Charles Baguley

MSc (Hons.), PhD, ONZM

Biography

Professor Bruce Baguley was born in Hamilton, New Zealand and studied at the University of Auckland. He trained initially in chemistry, switching to the field of molecular biology for his doctoral degree. He subsequently carried out post-doctoral studies in Basel, Switzerland on the biochemistry of normal and cancer tissue years before returning to New Zealand in 1968 to join what is now the Auckland Cancer Society Research Centre at the University of Auckland. He became Director of the Centre in 1981 and has since served as Director and Co-director. Professor Baguley lives in Auckland and is married with three children and four grandchildren.

Professor Baguley’s major research interest has been the development of anticancer drugs, with a particular focus on the operation of a multidisciplinary facility where new treatment strategies can be formulated and new drugs synthesised, and where comprehensive laboratory studies can be complemented by clinical trials in cancer patients. He is an author/co-author of over 440 research articles and book chapters, and in 2002 edited the book, with Professor DJ Kerr, "Anticancer Drug Development", which was the first large publication to provide a comprehensive overview of this field.

Professor Baguley was elected a Fellow of the Royal Society of New Zealand (FRSNZ) in 1991. In 2002 he was elected an Officer of the New Zealand Order of Merit (ONZM) for services to cancer research. In 2006 he was awarded the Sir Charles Hercus Medal for scientific or technological work of great merit in biomedical sciences and technologies. In this year he was also awarded the Sir Peter Gluckman Medal for distinguished contributions to the Faculty of Medical and Health Sciences at the University of Auckland. In 2011 he was awarded the title of Distinguished Professor at the University of Auckland.

Research Interests


Research Groups

Selected publications and creative works (Research Outputs)

  • Jin, Y., Wu, Z., Li, C., Zhou, W., Shaw, J. P., Baguley, B. C., ... Zhang, W. (2018). Optimization of Weight Ratio for DSPE-PEG/TPGS Hybrid Micelles to Improve Drug Retention and Tumor Penetration. Pharmaceutical research, 35 (1)10.1007/s11095-017-2340-y
    Other University of Auckland co-authors: Zimei Wu, John Shaw
  • Macaulay, E. C., Chatterjee, A., Cheng, X., Baguley, B. C., Eccles, M. R., & Morison, I. M. (2017). The Genes of Life and Death: A Potential Role for Placental-Specific Genes in Cancer: Active retrotransposons in the placenta encode unique functional genes that may also be used by cancer cells to promote malignancy. BioEssays : news and reviews in molecular, cellular and developmental biology10.1002/bies.201700091
  • Gamage, S. A., Giddens, A. C., Tsang, K. Y., Flanagan, J. U., Kendall, J. D., Lee, W.-J., ... Shepherd, P. R. (2017). Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic & medicinal chemistry, 25 (20), 5859-5874. 10.1016/j.bmc.2017.09.025
    Other University of Auckland co-authors: Gordon Rewcastle, Swarna Gamage, Anna Giddens, Bill Denny, Jack Flanagan, Jackie Kendall, Christina Buchanan, Stephen Jamieson
  • Zhang, W., Baguley, B. C., Shaw, J. P., Li, C., Liu, J., & Wu, Z. (2017). Strategies to improve Asulacrine retention within liposomes with DPPG and loading by glutathione gradient. Journal of Controlled Release. 10.1016/j.jconrel.2017.03.287
    Other University of Auckland co-authors: Zimei Wu, John Shaw
  • Sarkar, D., Oghabian, A., Bodiyabadu, P. K., Joseph, W. R., Leung, E. Y., Finlay, G. J., ... Askarian-Amiri, M. E. (2017). Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing. International Journal of Molecular Sciences, 18 (7)10.3390/ijms18071378
    Other University of Auckland co-authors: Wayne Joseph, Euphemia Leung, Graeme Finlay, Marjan Askarian Amiri, Debina Sarkar
  • Silva, J. M., Deuker, M. M., Baguley, B. C., & McMahon, M. (2017). PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation. Pigment cell & melanoma research, 30 (3), 353-367. 10.1111/pcmr.12586
  • Baguley, B. C. (2017). Topoisomerase 2. Cancer Therapeutic Targets (pp. 1053-1065). 10.1007/978-1-4419-0717-2_55
  • Kendall, J. D., Giddens, A. C., Tsang, K. Y., Marshall, E. S., Lill, C. L., Lee, W.-J., ... Yu, S. (2017). Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters, 27 (2), 187-190. 10.1016/j.bmcl.2016.11.078
    URL: http://hdl.handle.net/2292/34181
    Other University of Auckland co-authors: Bill Denny, Christina Buchanan, Gordon Rewcastle, Jackie Kendall, Stephen Jamieson, Anna Giddens

Contact details

Primary location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 138
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand