Dist Prof Bill Alexander Denny

ONZM, MSc PhD, DSc, FRSNZ, FNZIC

Biography

Trained at Auckland and Oxford Universities as a medicinal chemist/drug designer. Co-founding scientist of Proacta Therapeutics, and co-PI in the Centre for Molecular Bioscience, University of Auckland. Past-President of the NZ Society for Oncology and the NZ Institute of Chemistry. Rutherford Medallist of the Royal Society of NZ, and Adrian Albert Medallist of the UK Royal Society of Chemistry. Officer of the NZ Order of Merit for services to cancer research.

Bill leads the Medicinal Chemistry Group at the Auckland Cancer Society Research Centre.

Research interests

Selected publications and creative works (Research Outputs)

  • Spicer, J. A., Miller, C. K., O'Connor PD, Jose, J., Huttunen, K. M., Jaiswal, J. K., ... Trapani, J. A. (2017). Substituted arylsulphonamides as inhibitors of perforin-mediated lysis. European journal of medicinal chemistry, 137, 139-155. 10.1016/j.ejmech.2017.05.048
    Other University of Auckland co-authors: Christian Miller, Julie Spicer, Jiney Jose, Jagdish Jaiswal
  • Rewcastle, G. W., Kolekar, S., Buchanan, C. M., Gamage, S. A., Giddens, A. C., Tsang, K. Y., ... Smith, G. C. (2017). Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors. Oncotarget, 8 (29), 47725-47740. 10.18632/oncotarget.17730
    URL: http://hdl.handle.net/2292/34774
    Other University of Auckland co-authors: Gordon Rewcastle, Christina Buchanan, Swarna Gamage, Stephen Jamieson, Jackie Kendall, Anna Giddens
  • Gong, G. Q., Kendall, J. D., Dickson, J. M. J., Rewcastle, G. W., Buchanan, C. M., Denny, W. A., ... Flanagan, J. U. (2017). Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity. Biochemical Journal, 474 (13), 2261-2276. 10.1042/bcj20161098
    Other University of Auckland co-authors: Gordon Rewcastle, James Dickson, Christina Buchanan, Jack Flanagan, Jackie Kendall
  • Thompson, A. M., Blaser, A., Palmer, B. D., Anderson, R. F., Shinde, S. S., Launay, D., ... Wan, B. (2017). 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases. Bioorganic & medicinal chemistry letters, 27 (11), 2583-2589. 10.1016/j.bmcl.2017.03.069
    Other University of Auckland co-authors: Brian Palmer, Andrew Thompson, Adrian Blaser, Bob Anderson
  • Thompson, A. M., O'Connor PD, Marshall, A. J., Yardley, V., Maes, L., Gupta, S., ... Franzblau, S. G. (2017). 7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. Journal of medicinal chemistry, 60 (10), 4212-4233. 10.1021/acs.jmedchem.7b00034
    Other University of Auckland co-authors: Andrew Thompson
  • Dissanayake, S., Denny, W. A., Gamage, S., & Sarojini, V. (2017). Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides. Journal of controlled release : official journal of the Controlled Release Society, 250, 62-76. 10.1016/j.jconrel.2017.02.006
    Other University of Auckland co-authors: Viji Sarojini
  • Spicer, J. A., Miller, C. K., O'Connor PD, Jose, J., Huttunen, K. M., Jaiswal, J. K., ... Trapani, J. A. (2017). Benzenesulphonamide inhibitors of the cytolytic protein perforin. Bioorganic & medicinal chemistry letters, 27 (4), 1050-1054. 10.1016/j.bmcl.2016.12.057
    Other University of Auckland co-authors: Julie Spicer, Christian Miller, Jiney Jose, Jagdish Jaiswal
  • Campbell, A. P., Wakelin, L. P. G., Denny, W. A., & Finch, A. M. (2017). Homobivalent Conjugation Increases the Allosteric Effect of 9-aminoacridine at the α 1 -Adrenergic Receptors. Molecular Pharmacology, 91 (2), 135-144. 10.1124/mol.116.105874

Contact details

Primary location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 140
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand