Dist Prof Bill Alexander Denny

ONZM, MSc PhD, DSc, FRSNZ, FNZIC

Biography

Trained at Auckland and Oxford Universities as a medicinal chemist/drug designer. Co-founding scientist of Proacta Therapeutics, and co-PI in the Centre for Molecular Bioscience, University of Auckland. Past-President of the NZ Society for Oncology and the NZ Institute of Chemistry. Rutherford Medallist of the Royal Society of NZ, and Adrian Albert Medallist of the UK Royal Society of Chemistry. Officer of the NZ Order of Merit for services to cancer research.

Bill leads the Medicinal Chemistry Group at the Auckland Cancer Society Research Centre.

Research interests

Selected publications and creative works (Research Outputs)

  • Thompson, A. M., O'Connor PD, Marshall, A. J., Francisco, A. F., Kelly, J. M., Riley, J., ... Thompson, R. C. A. (2020). Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy. European Journal of Medicinal Chemistry, 207.10.1016/j.ejmech.2020.112849
    Other University of Auckland co-authors: Andrew Thompson
  • Lu, G.-L., Tong, A. S. T., Conole, D., Sutherland, H. S., Choi, P. J., Franzblau, S. G., ... Denny, W. A. (2020). Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis. Bioorganic & medicinal chemistry, 28 (22)10.1016/j.bmc.2020.115784
    Other University of Auckland co-authors: Peter Choi, Leon Lu
  • Serobian, A., Pracey, C. P., Thomas, D. S., Denny, W. A., Ball, G. E., & Wakelin, L. P. G. (2020). Structures and dynamics of DNA complexes of the desmethyl analog of the cytotoxin MLN944: Insights into activity when a methyl isn't futile. Journal of molecular recognition : JMR, 33 (8)10.1002/jmr.2843
    URL: http://hdl.handle.net/2292/51461
  • Choi, P. J., Park, T. I. H., Cooper, E., Dragunow, M., Denny, W. A., & Jose, J. (2020). Heptamethine Cyanine Dye Mediated Drug Delivery: Hype or Hope. Bioconjugate chemistry, 31 (7), 1724-1739. 10.1021/acs.bioconjchem.0c00302
    Other University of Auckland co-authors: Jiney Jose, Thomas Park, Peter Choi
  • Choi, P. J., Cooper, E., Schweder, P., Mee, E., Turner, C., Faull, R., ... Jose, J. (2020). PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines. Bioorganic & medicinal chemistry letters, 30 (14)10.1016/j.bmcl.2020.127252
    Other University of Auckland co-authors: Peter Choi, Michael Dragunow, Thomas Park, Jiney Jose, Richard Faull
  • Dimitrov, I. V., Harvey, M. G., Voss, L. J., Sleigh, J. W., Bickerdike, M. J., & Denny, W. A. (2020). Structure-Activity Relationships for the Anaesthetic and Analgaesic Properties of Aromatic Ring-Substituted Ketamine Esters. Molecules (Basel, Switzerland), 25 (12).10.3390/molecules25122950
    Other University of Auckland co-authors: Jamie Sleigh
  • Zhuang, Z., Wan, D., Ding, J., He, S., Zhang, Q., Wang, X., ... Lynch, A. S. (2020). Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria. Molecules (Basel, Switzerland), 25 (10).10.3390/molecules25102431
  • Choi, P. J., Conole, D., Sutherland, H. S., Blaser, A., Tong, A. S. T., Cooper, C. B., ... Denny, W. A. (2020). Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogueof Bedaquiline. Molecules (Basel, Switzerland), 25 (6).10.3390/molecules25061423
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Brian Palmer

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 140
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand