Dist Prof Bill Alexander Denny



Trained at Auckland and Oxford Universities as a medicinal chemist/drug designer. Co-founding scientist of Proacta Therapeutics, and co-PI in the Centre for Molecular Bioscience, University of Auckland. Past-President of the NZ Society for Oncology and the NZ Institute of Chemistry. Rutherford Medallist of the Royal Society of NZ, and Adrian Albert Medallist of the UK Royal Society of Chemistry. Officer of the NZ Order of Merit for services to cancer research.

Bill leads the Medicinal Chemistry Group at the Auckland Cancer Society Research Centre.

Research interests

Selected publications and creative works (Research Outputs)

  • Choi, P. J., Cooper, E., Schweder, P., Mee, E., Turner, C., Paull, R., ... Jose, J. (2020). PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 30 (14)10.1016/j.bmcl.2020.127252
    URL: http://hdl.handle.net/2292/51570
    Other University of Auckland co-authors: Peter Choi, Michael Dragunow, Thomas Park, Jiney Jose, Richard Faull
  • Zhuang, Z., Wan, D., Ding, J., He, S., Zhang, Q., Wang, X., ... Lynch, A. S. (2020). Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria. Molecules (Basel, Switzerland), 25 (10).10.3390/molecules25102431
  • Choi, P. J., Conole, D., Sutherland, H. S., Blaser, A., Tong, A. S. T., Cooper, C. B., ... Denny, W. A. (2020). Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogueof Bedaquiline. Molecules (Basel, Switzerland), 25 (6).10.3390/molecules25061423
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Brian Palmer
  • Spicer, J. A., Miller, C. K., O'Connor PD, Jose, J., Giddens, A. C., Jaiswal, J. K., ... Akhlaghi, H. (2020). Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo. Journal of medicinal chemistry, 63 (5), 2229-2239. 10.1021/acs.jmedchem.9b00881
    Other University of Auckland co-authors: Julie Spicer, Christian Miller, Jiney Jose, Stephen Jamieson, Jagdish Jaiswal, Matthew Bull
  • Serobian, A., Pracey, C. P., Thomas, D. S., Denny, W. A., Ball, G. E., & Wakelin, L. P. G. (2020). Structures and dynamics of DNA complexes of the desmethyl analog of the cytotoxin MLN944: Insights into activity when a methyl isn't futile. Journal of Molecular Recognition10.1002/jmr.2843
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Palmer, B. D. (2020). Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology. Bioorganic & medicinal chemistry, 28 (1)10.1016/j.bmc.2019.115213
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Brian Palmer
  • Harvey, M., Sleigh, J., Voss, L., Bickerdike, M., Dimitrov, I., & Denny, W. (2019). KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects. BMC pharmacology & toxicology, 20 (1)10.1186/s40360-019-0374-y
    URL: http://hdl.handle.net/2292/49791
    Other University of Auckland co-authors: Jamie Sleigh, Ivo Dimitrov
  • Fernandes, G. F. S., Denny, W. A., & Dos Santos, J. L. (2019). Boron in drug design: Recent advances in the development of new therapeutic agents. European journal of medicinal chemistry, 179, 791-804. 10.1016/j.ejmech.2019.06.092

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 140
New Zealand