Dist Prof Bill Alexander Denny



Trained at Auckland and Oxford Universities as a medicinal chemist/drug designer. Co-founding scientist of Proacta Therapeutics, and co-PI in the Centre for Molecular Bioscience, University of Auckland. Past-President of the NZ Society for Oncology and the NZ Institute of Chemistry. Rutherford Medallist of the Royal Society of NZ, and Adrian Albert Medallist of the UK Royal Society of Chemistry. Officer of the NZ Order of Merit for services to cancer research.

Bill leads the Medicinal Chemistry Group at the Auckland Cancer Society Research Centre.

Research interests

Selected publications and creative works (Research Outputs)

  • Jacobson, G. M., Voss, L. J., Klockars, A., Bird, S., Dimitrov, I., Denny, W. A., ... Harvey, M. G. (2019). Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain. BMC genomics, 20 (1)10.1186/s12864-019-5649-6
    Other University of Auckland co-authors: Jamie Sleigh
  • Giddens, A. C., Gamage, S. A., Kendall, J. D., Lee, W.-J., Baguley, B. C., Buchanan, C. M., ... Denny, W. A. (2019). Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic & medicinal chemistry, 27 (8), 1529-1545. 10.1016/j.bmc.2019.02.050
    Other University of Auckland co-authors: James Dickson, Anna Giddens, Swarna Gamage, Woo Lee, Stephen Jamieson, Gordon Rewcastle
  • Blaser, A., Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline. Bioorganic & medicinal chemistry, 27 (7), 1283-1291. 10.1016/j.bmc.2019.02.025
    Other University of Auckland co-authors: Adrian Blaser, Peter Choi, Brian Palmer
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorganic & medicinal chemistry, 27 (7), 1292-1307. 10.1016/j.bmc.2019.02.026
    Other University of Auckland co-authors: Peter Choi, Brian Palmer, Adrian Blaser
  • Dimitrov, I. V., Harvey, M. G., Voss, L. J., Sleigh, J. W., Bickerdike, M. J., & Denny, W. A. (2019). Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain. Bioorganic & medicinal chemistry, 27 (7), 1226-1231. 10.1016/j.bmc.2019.02.010
    Other University of Auckland co-authors: Jamie Sleigh, Ivo Dimitrov
  • Gamage, S. A., Spicer, J. A., Tsang, K. Y., O'Connor PD, Flanagan, J. U., Lee, W.-J., ... Rewcastle, G. W. (1/4/2019). Synthesis and Evaluation of Imidazo[1,2-a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3-Kinase Inhibitors.. Chemistry, an Asian journal. 10.1002/asia.201801762
    URL: http://hdl.handle.net/2292/46733
    Other University of Auckland co-authors: Gordon Rewcastle, Swarna Gamage, Julie Spicer, James Dickson
  • Field, J. J., Singh, A. J., Sinha, S., Rowe, M. R., Denny, W. A., Brooke, D. G., & Miller, J. H. (2019). Synthesis and Microtubule-Destabilizing Activity of N-Cyclopropyl-4-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)benzamide and its Analogs. Chemistry, an Asian journal, 14 (8), 1151-1157. 10.1002/asia.201801313
  • Gamage, S., Giddens, A. C., Tsang, K. Y., Flanagan, J. U., Kendall, J. D., Lee, W. J., ... Shepherd, P. R. (2018). A journey of developing a new class of active and potent PI3Kalpha inhibitors. Paper presented at 30th EORTC-NCI-AACR Symposium, Dublin, IRELAND. 13 November - 16 November 2018. EUROPEAN JOURNAL OF CANCER. (pp. 1).
    Other University of Auckland co-authors: Stephen Jamieson, Gordon Rewcastle

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 140
New Zealand