Associate Professor Brian Desmond Palmer

MSc, PhD

Biography

Brian Palmer obtained his MSc and PhD degrees in Organic Chemistry from The University of Auckland, working with Prof. Con Cambie. Following postdoctoral research with Prof. Steve Ley at Imperial College, London, he joined the Centre in 1984 as a medicinal chemist. He is currently group leader of a collaborative project with the Global Alliance for TB Drug Development (GATB), which seeks to develop novel, affordable drugs for the treatment of tuberculosis. He is an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery at the University of Auckland.

Research interests

Research | Current

  • The design and synthesis of nitroheterocycles as antituberculosis agents.
  • The design and synthesis of novel thalidomide analogs as modulators of cytokine production, for use as anticancer agents.
  • Small molecule ATP-competitive kinase inhibitors as modulators of cell cycle checkpoint control.

Research group

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Choi, P. J., Conole, D., Sutherland, H. S., Blaser, A., Tong, A. S. T., Cooper, C. B., ... Denny, W. A. (2020). Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogueof Bedaquiline. Molecules (Basel, Switzerland), 25 (6).10.3390/molecules25061423
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Palmer, B. D. (2020). Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology. Bioorganic & medicinal chemistry, 28 (1)10.1016/j.bmc.2019.115213
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny
  • Kanamala, M., Palmer, B. D., Jamieson, S. M., Wilson, W. R., & Wu, Z. (2019). Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery. Nanomedicine (London, England), 14 (15), 1971-1989. 10.2217/nnm-2018-0510
    Other University of Auckland co-authors: Stephen Jamieson, Zimei Wu
  • Blaser, A., Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline. Bioorganic & medicinal chemistry, 27 (7), 1283-1291. 10.1016/j.bmc.2019.02.025
    Other University of Auckland co-authors: Bill Denny, Adrian Blaser, Peter Choi
  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorganic & medicinal chemistry, 27 (7), 1292-1307. 10.1016/j.bmc.2019.02.026
    Other University of Auckland co-authors: Bill Denny, Peter Choi, Adrian Blaser
  • Choi, P., Sutherland, H., Tong, A., Conole, D., Blaser, A., Cooper, C., ... Palmer, B. (31/3/2019). Next-generation bedaquiline for the treatment of tuberculosis. Poster presented at 257th National Meeting of the American-Chemical-Society (ACS), Orlando, FL. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny
  • Kanamala, M., Palmer, B. D., Wilson, W. R., & Wu, Z. (2018). Characterization of a smart pH-cleavable PEG polymer towards the development of dual pH-sensitive liposomes. International journal of pharmaceutics, 548 (1), 288-296. 10.1016/j.ijpharm.2018.07.009
    Other University of Auckland co-authors: Zimei Wu
  • Kanamala, M., Palmer, B. D., Ghandehari, H., Wilson, W. R., & Wu, Z. (2018). PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation. Pharmaceutical research, 35 (8)10.1007/s11095-018-2429-y
    Other University of Auckland co-authors: Zimei Wu

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 119
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand