Associate Professor Brian Desmond Palmer

MSc, PhD

Biography

Brian Palmer obtained his MSc and PhD degrees in Organic Chemistry from The University of Auckland, working with Prof. Con Cambie. Following postdoctoral research with Prof. Steve Ley at Imperial College, London, he joined the Centre in 1984 as a medicinal chemist. He is currently group leader of a collaborative project with the Global Alliance for TB Drug Development (GATB), which seeks to develop novel, affordable drugs for the treatment of tuberculosis. He is an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery at the University of Auckland.

Research interests

Research | Current

  • The design and synthesis of nitroheterocycles as antituberculosis agents.
  • The design and synthesis of novel thalidomide analogs as modulators of cytokine production, for use as anticancer agents.
  • Small molecule ATP-competitive kinase inhibitors as modulators of cell cycle checkpoint control.

Research group

Selected publications and creative works (Research Outputs)

  • Choi, P. J., Sutherland, H. S., Tong, A. S. T., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Motte, M. (2017). Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units. Bioorganic & medicinal chemistry letters10.1016/j.bmcl.2017.10.042
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny
  • Tong, A., Choi, P., Blaser, A., Sutherland, H. S., Tsang, S., Guillemont, J., ... Broeck, W. V. D. (2017). 6-Cyano analogues of bedaquiline as less lipophilic and potentially safer diarylquinolines for tuberculosis. ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.7b00196
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny
  • Thompson, A. M., Blaser, A., Palmer, B. D., Anderson, R. F., Shinde, S. S., Launay, D., ... Wan, B. (2017). 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases. Bioorganic & medicinal chemistry letters, 27 (11), 2583-2589. 10.1016/j.bmcl.2017.03.069
    Other University of Auckland co-authors: Andrew Thompson, Adrian Blaser, Bob Anderson, Bill Denny
  • Tomek, P., Palmer, B. D., Flanagan, J. U., Sun, C., Raven, E. L., & Ching, L.-M. (2017). Discovery and evalution of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. European Journal of Medicinal Chemistry, 126, 983-996. 10.1016/j.ejmech.2016.12.029
    Other University of Auckland co-authors: Lai-Ming Ching, Petr Tomek, Jack Flanagan
  • Smaill, J. B., Gonzales, A. J., Spicer, J. A., Lee, H., Reed, J. E., Sexton, K., ... Blaser, A. (2016). Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4- d ]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family. Journal of Medicinal Chemistry, 59 (17), 8103-8124. 10.1021/acs.jmedchem.6b00883
    URL: http://hdl.handle.net/2292/32487
    Other University of Auckland co-authors: Jeffrey Smaill, Bill Denny, Andrew Thompson, Julie Spicer, Adrian Blaser
  • Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z. (2016). Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review. Biomaterials, 85, 152-167. 10.1016/j.biomaterials.2016.01.061
    Other University of Auckland co-authors: Zimei Wu, William Wilson
  • Thompson, A. M., Blaser, A., Palmer, B. D., Franzblau, S. G., Wan, B., Wang, Y., ... Denny, W. A. (2015). Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy. Bioorganic & Medicinal Chemistry Letters, 25 (18), 3804-3809. 10.1016/j.bmcl.2015.07.084
    Other University of Auckland co-authors: Adrian Blaser, Bill Denny, Andrew Thompson
  • Tomek, P., Palmer, B. D., Kendall, J. D., Flanagan, J. U., & Ching, L.-M. (2015). Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine. Biochimica et biophysica acta, 1850 (9), 1772-1780. 10.1016/j.bbagen.2015.04.007
    Other University of Auckland co-authors: Jack Flanagan, Petr Tomek, Jackie Kendall, Lai-Ming Ching

Contact details

Primary location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 119
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand