Associate Professor Brian Desmond Palmer
Brian Palmer obtained his MSc and PhD degrees in Organic Chemistry from The University of Auckland, working with Prof. Con Cambie. Following postdoctoral research with Prof. Steve Ley at Imperial College, London, he joined the Centre in 1984 as a medicinal chemist. He is currently group leader of a collaborative project with the Global Alliance for TB Drug Development (GATB), which seeks to develop novel, affordable drugs for the treatment of tuberculosis. He is an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery at the University of Auckland.
Research | Current
- The design and synthesis of nitroheterocycles as antituberculosis agents.
- The design and synthesis of novel thalidomide analogs as modulators of cytokine production, for use as anticancer agents.
- Small molecule ATP-competitive kinase inhibitors as modulators of cell cycle checkpoint control.
Selected publications and creative works (Research Outputs)
- Kanamala, M., Palmer, B. D., Wilson, W. R., & Wu, Z. (2018). Characterization of a smart pH-cleavable PEG polymer towards the development of dual pH-sensitive liposomes. International Journal of Pharmaceutics, 548 (1), 288-296. 10.1016/j.ijpharm.2018.07.009
- Kanamala, M., Palmer, B. D., Ghandehari, H., Wilson, W. R., & Wu, Z. (2018). PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation. Pharmaceutical research, 35 (8)10.1007/s11095-018-2429-y
Other University of Auckland co-authors: Zimei Wu
- Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Blaser, A., Franzblau, S. G., ... Denny, W. A. (2018). Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles. Bioorganic & medicinal chemistry, 26 (8), 1797-1809. 10.1016/j.bmc.2018.02.026
Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny, Hamish Sutherland
- Choi, P. J., Sutherland, H. S., Tong, A. S., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Motte, M. (2017). Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units. Bioorganic and Medicinal Chemistry Letters, 27 (23), 5190-5196. 10.1016/j.bmcl.2017.10.042
Other University of Auckland co-authors: Hamish Sutherland, Peter Choi, Adrian Blaser, Bill Denny
- Ching, L. M., Tomek, P., Palmer, B., Tijono, S., Henare, K., Braun, L., & de Leeuw, M. (15/10/2017). Assays and models for in vitro and in vivo evaluation of small molecule inhibitors of tryptophan dioxygenase. Poster presented at New Zealand Society for Oncology Conference 2017, Auckland, New Zealand.
Other University of Auckland co-authors: Lai-Ming Ching, Petr Tomek, Kimi Henare
- Tong, A. S., Choi, P. J., Blaser, A., Sutherland, H. S., Tsang, S. K., Guillemont, J., ... Van den Broeck, W. (2017). 6-cyano analogues of bedaquiline as less lipophilic and potentially safer diarylquinolines for tuberculosis. ACS Medicinal Chemistry Letters, 8 (10), 1019-1024. 10.1021/acsmedchemlett.7b00196
Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Hamish Sutherland, Bill Denny
- Choi, P. J., Tong, S. T., Denny, W. A., Palmer, B. D., Blaser, A., Conole, D., ... Upton, A. M. (7/9/2017). Synthetic studies towards the development of less lipophilic drug of bedaquiline. Poster presented at Queenstown Research Week, Rydges Hotel, Queenstown, New Zealand. National Symposium on Infectious Diseases: key opportunities and emerging therapies.
Other University of Auckland co-authors: Peter Choi, Bill Denny, Adrian Blaser, Hamish Sutherland
- Thompson, A., Blaser, A., Palmer, B., Anderson, R., Shinde, S., Launay, D., ... Wan, B. (2017). 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases. Bioorganic and Medicinal Chemistry Letters, 27 (11), 2583-2589. 10.1016/j.bmcl.2017.03.069
Other University of Auckland co-authors: Andrew Thompson, Adrian Blaser, Bob Anderson, Bill Denny