Dr Barbara Lipert

PhD (Biochemistry)

Biography

I am a cellular and molecular biologist, with a particular interest in the clinical application of CRISPR technology. I obtained a PhD in Biochemistry at the Jagiellonian University in Krakow, Poland (2016) where I studied a newly discovered gene in the context of carcinogenesis and cell differentiation (adipogenesis). In 2017, I joined the Auckland Cancer Society Research Centre (ACSRC) where I apply CRISPR technologies in functional genomics studies. 

Research | Current

1. DNA repair mechanisms in cancer cells - exploiting weaknesses to improve treatment

2. Identification of the biomarkers for precision oncology:

  • CRISPR knock-out genetic screens for the whole-genome interrogation of genetic dependencies to anticancer therapies - chemotherapy, radiotherapy and antibody-drug conjugate T-DM1 (Kadcyla®)
  • Generating knock-in and knock-out model cell lines for validation studies

Postgraduate supervision

Co-supervisor of Masters Project: Identification of genes that confer tolerance to tumour microenvironmental stress using CRISPR-Cas9 screens. Ms Hanting Yong, 2019. 

Co-supervisor of Honours Project: In Pursuit of Precision: Determinants of sensitivity and resistance to the drug trastuzumab emtansine for HER2-positive breast cancer. Ms Hilary Barker, 2018. 

Supervisor of the Summer Student Projects in 2019-2021.

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Hunter, F. W., Barker, H. R., Lipert, B., Rothé F, Gebhart, G., Piccart-Gebhart, M. J., ... Jamieson, S. M. F. (2020). Mechanisms of resistance to trastuzumab emtansine (T-DM1) in HER2-positive breast cancer. British journal of cancer, 122 (5), 603-612. 10.1038/s41416-019-0635-y
    Other University of Auckland co-authors: Stephen Jamieson, Francis Hunter
  • Lee, T. W., Wong, W. W., Dickson, B. D., Lipert, B., Cheng, G. J., Hunter, F. W., ... Wilson, W. R. (2019). Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. International journal of radiation biology, 95 (12), 1597-1612. 10.1080/09553002.2019.1664787
    Other University of Auckland co-authors: Francis Hunter, Benjamin Dickson, Michael Hay, Way Wong
  • Wong, W. W., Jackson, R. K., Liew, L. P., Dickson, B. D., Cheng, G. J., Lipert, B., ... Hay, M. P. (2019). Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361. Biochemical pharmacology, 16910.1016/j.bcp.2019.113641
    Other University of Auckland co-authors: Way Wong, Benjamin Dickson, Yongchuan Gu, Francis Hunter, William Wilson, Michael Hay, Lydia Liew
  • Ligeza, J., Marona, P., Gach, N., Lipert, B., Miekus, K., Wilk, W., ... Dulak, J. (2017). MCPIP₁ contributes to clear cell renal cell carcinomas development. Angiogenesis, 20 (3), 325-340. 10.1007/s10456-017-9540-2
  • Lipert, B., Wilamowski, M., Gorecki, A., & Jura, J. (2017). MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ. PloS one, 12 (3)10.1371/journal.pone.0174381
  • Ruiz-Romeu, E., Ferran, M., Giménez-Arnau A, Bugara, B., Lipert, B., Jura, J., ... Pujol, R. M. (2016). MCPIP1 RNase is aberrantly distributed in psoriatic epidermis and rapidly induced by IL-17A. Journal of Investigative Dermatology, 136 (8), 1599-1607. 10.1016/j.jid.2016.04.030
  • Lipert, B. (2016). Rola MCPIP1 w różnicowaniu preadipocytów (Determining the role of MCPIP1 ribonuclease in adipogenesis) The Jagiellonian University, Krakow, Poland. The Jagiellonian University, Krakow, Poland.
  • Labedz-Maslowska, A., Lipert, B., Berdecka, D., Kedracka-Krok, S., Jankowska, U., Kamycka, E., ... Jura, J. (2015). Monocyte chemoattractant protein-induced protein 1 (MCPIP1) enhances angiogenic and cardiomyogenic potential of murine bone marrow-derived mesenchymal stem cells. PloS ONE, 10 (7)10.1371/journal.pone.0133746

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 0, Room 013
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand