Dr Brya Matthews

BSc (Hons), PhD


Brya Matthews completed her PhD at the University of Auckland, and after a short time doing postdoctoral work in Auckland, completed further postdoctoral research at the University of Connecticut School of Dental Medicine in Connecticut, USA. She was later promoted to Instructor then Assistant Professor before returning to New Zealand in 2017 to take up a Sir Charles Hercus Fellowship in the Department of Molecular Medicine.

Research | Current

I am interested in adult stem cells involved in bone healing. My research focuses on identifying stem cell populations in the periosteum, the tissue that surrounds the outside of the bone, and examining how these cells respond to injury. I am also interested in other aspects of bone healing, including the role of innervation in regeneration, as well as understanding the bone phenotype in animal models of disrupted metabolism.

I am also interested in understanding and treating bone-associated infection. This includes infections with hardware or prosthetics, and osteomyelitis where the source of infection may not be clear. We are focused on Staphylococcus aureus as the main organism causing infection.

Teaching | Current

MEDSCI315 Nutrigenomics - bone biology and nutrition

MEDSCI740 Stem cell biology and transgenesis

MEDSCI312 Endocrinology - guest lecture on metabolic bone disease

Postgraduate supervision

  • Ye Cao - PhD candidate
  • Joey Tan - MHSc (Nutrition and Dietetics) candidate


  • Mei Lin Tay - PhD candidate
  • Stuart Irwin - PhD candidate

Areas of expertise

Bone biology

Mesenchymal/skeletal stem cells

Fracture healing and bone regeneration

MicroCT imaging of bone

Committees/Professional groups/Services

Departmental Graduate Advisor for Molecular Medicine and Pathology

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Cao, Y., Buckels, E. J., & Matthews, B. G. (2020). Markers for Identification of Postnatal Skeletal Stem Cells In Vivo. Current osteoporosis reports10.1007/s11914-020-00622-2
    Other University of Auckland co-authors: Emma Buckels, Ye Cao
  • Root, S. H., Wee, N. K. Y., Novak, S., Rosen, C. J., Baron, R., Matthews, B. G., & Kalajzic, I. (2020). Perivascular osteoprogenitors are associated with transcortical channels of long bones. Stem cells (Dayton, Ohio), 38 (6), 769-781. 10.1002/stem.3159
  • Novak, S., Roeder, E., Sinder, B. P., Adams, D. J., Siebel, C. W., Grcevic, D., ... Kalajzic, I. (2020). Modulation of Notch1 signaling regulates bone fracture healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society10.1002/jor.24650
  • Matthews, B. G., Wee, N. K. Y., Widjaja, V. N., Price, J. S., Kalajzic, I., & Windahl, S. H. (2020). αSMA Osteoprogenitor Cells Contribute to the Increase in Osteoblast Numbers in Response to Mechanical Loading. Calcified tissue international, 106 (2), 208-217. 10.1007/s00223-019-00624-y
  • Sinder, B. P., Novak, S., Wee, N. K. Y., Basile, M., Maye, P., Matthews, B. G., & Kalajzic, I. (2019). Engraftment of skeletal progenitor cells by bone directed transplantation improves osteogenesis imperfecta murine bone phenotype. Stem cells (Dayton, Ohio)10.1002/stem.3133
  • Wee, N. K. Y., Sinder, B. P., Novak, S., Wang, X., Stoddard, C., Matthews, B. G., & Kalajzic, I. (2019). Skeletal phenotype of the neuropeptide Y knockout mouse. Neuropeptides, 73, 78-88. 10.1016/j.npep.2018.11.009
  • Matthews, B. G., Ono, N., & Kalajzic, I. (2019). Methods in lineage tracing. Principles of Bone Biology (pp. 1887-1898). 10.1016/B978-0-12-814841-9.00081-6
  • Vidovic Zdrilic, I., de Azevedo Queiroz, I. O., Matthews, B. G., Gomes-Filho, J. E., Mina, M., & Kalajzic, I. (2017). Mineral trioxide aggregate improves healing response of periodontal tissue to injury in mice. Journal of periodontal research, 52 (6), 1058-1067. 10.1111/jre.12478

Contact details

Primary office location

M&HS BUILDING 502 - Bldg 502
Level 2, Room 201
New Zealand