Dr Brya Matthews

BSc (Hons), PhD

Senior Research Fellow

In: Molecular Medicine and Pathology » Medical Science » Faculty of Medical and Health Sciences

Biography

Brya Matthews completed her PhD at the University of Auckland, and after a short time doing postdoctoral work in Auckland, completed further postdoctoral research at the University of Connecticut School of Dental Medicine in Connecticut, USA. She was later promoted to Instructor then Assistant Professor before returning to New Zealand in 2017 to take up a Sir Charles Hercus Fellowship in the Department of Molecular Medicine.

Research | Current

I am interested in adult stem cells involved in bone healing. My research focuses on identifying stem cell populations in the periosteum, the tissue that surrounds the outside of the bone, and examining how these cells respond to injury. I am also interested in other aspects of bone healing, including the role of innervation in regeneration, as well as understanding the bone phenotype in animal models of disrupted metabolism.

Teaching | Current

MEDSCI315 Nutrigenomics - bone biology and nutrition

MEDSCI740 Stem cell biology and transgenesis

MEDSCI312 Endocrinology - guest lecture on metabolic bone disease

Postgraduate supervision

I am recruiting all types of graduate students. Please see Find-a-thesis for projects available. I have a doctoral scholarship available for qualified students.

Areas of expertise

Bone biology

Mesenchymal/skeletal stem cells

Fracture healing

Selected publications and creative works (Research Outputs)

Wee, N. K. Y., Sinder, B. P., Novak, S., Wang, X., Stoddard, C., Matthews, B. G., & Kalajzic, I. (2019). Skeletal phenotype of the neuropeptide Y knockout mouse. Neuropeptides, 73, 78-88. 10.1016/j.npep.2018.11.009
Vidovic Zdrilic, I., de Azevedo Queiroz, I. O., Matthews, B. G., Gomes-Filho, J. E., Mina, M., & Kalajzic, I. (2017). Mineral trioxide aggregate improves healing response of periodontal tissue to injury in mice. Journal of periodontal research, 52 (6), 1058-1067. 10.1111/jre.12478
URL: http://hdl.handle.net/2292/42764
Matthews, B. G., Roeder, E., Wang, X., Aguila, H. L., Lee, S.-K., Grcevic, D., & Kalajzic, I. (2017). Splenomegaly, myeloid lineage expansion and increased osteoclastogenesis in osteogenesis imperfecta murine. Bone, 103, 1-11. 10.1016/j.bone.2017.06.004
URL: http://hdl.handle.net/2292/43240
Vidovic, I., Banerjee, A., Fatahi, R., Matthews, B., Dyment, N., Kalajzic, I., & Mina, M. (2017). αSMA-expressing perivascular cells represent dental pulp progenitors In vivo. Journal of Dental Research, 96 (3), 323-330. 10.1177/0022034516678208
URL: http://hdl.handle.net/2292/42772
Matic, I., Matthews, B. G., Wang, X., Dyment, N. A., Worthley, D. L., Rowe, D. W., ... Kalajzic, I. (2016). Quiescent bone lining cells are a major source of osteoblasts during adulthood. Stem Cells, 34 (12), 2930-2942. 10.1002/stem.2474
URL: http://hdl.handle.net/2292/43228
Joo Kim, J., Musson, D. S., Matthews, B. G., Cornish, J., Anderson, I. A., & Shim, V. B. (2016). Applying physiologically relevant strains to tenocytes in an in vitro cell device induces in vivo like behaviors. Journal of Biomechanical Engineering, 138 (12)10.1115/1.4034031
URL: http://hdl.handle.net/2292/31533
Other University of Auckland co-authors: Vickie Shim, Jillian Cornish, Iain Anderson, David Musson
Roeder, E., Matthews, B. G., & Kalajzic, I. (2016). Visual reporters for study of the osteoblast lineage. Bone, 92, 189-195. 10.1016/j.bone.2016.09.004
URL: http://hdl.handle.net/2292/41219
Matthews, B., Roguljic, H., Franceschetti, T., Roeder, E., Matic, I., Vidovic, I., ... Kalajzic, I. (2016). Gene-expression analysis of cementoblasts and osteoblasts. Journal of Periodontal Research, 51 (3), 304-312. 10.1111/jre.12309
URL: http://hdl.handle.net/2292/42763