Dr Catherine Elizabeth Angel
BSc (Hons), MSc, PhD
Research | Current
Antigen presenting cells (APCs) are the sentinel cells of the immune system. APCs have the capacity to detect invading pathogens and stimulate a tailored immune response. APCs are therefore often considered as potential therapeutic targets.
My team’s research focus is the study of the APC populations in human tissues e.g. blood, skin, lymph node and the tissues of the central nervous system. We aim to determine the precise role that human APC subsets have in initiating and mediating immune responses, in particular T-lymphocyte responses to pathogens or vaccines.
We are also interested in the human lymph node; APCs drain from peripheral tissues into lymph nodes and it is here that they encounter and stimulate blood derived T-lymphocytes. We study how the cellular architecture of the lymph node (e.g. the fibroreticular and endothelial networks) helps orchestrate an immune response. In addition to these core projects, we are involved in related research programmes that we have established with collaborators.
We conduct our research using cells isolated from human tissue. This enables us to generate valuable human data relevant to immunologists and the pharmaceutical industry. We utilise a wide variety of techniques including novel cell isolation and culture procedures, fluorescent immunohistochemistry and flow cytometry.
- Determining how human antigen presenting cells respond to foreign pathogens
- Characterisation of antigen presenting cells in human skin
- Antigen presentation to human T-lymphocytes - in collaboration with Prof. Rod Dunbar (SBS, UoA)
- Structural components of the human lymph node - in collaboration with Prof. Rod Dunbar (SBS, UoA)
- Identification of Cannabinoid Receptor 2 (CB2) positive immune cells in multiple sclerosis lesions in the human brain and investigation of physiological function of CB2 in disease - in collaboration with Dr Scott Graham (FMHS, UoA)
- Determining how inflammatory mediators influence human endothelial cells - in collaboration with Dr Scott Graham (FMHS, UoA)
Teaching | Current
BIOSCI101 - Cell and Molecular Biology (1st Semester)
BIOSCI356 - Developmental Biology and Cancer (1st Semester)
BIOSCI759 - Cellular and Molecular Biomedicine (Co-ordinator) (2nd Semester)
Elyce du Mez
Akshata Anchan (with Dr ES Graham, FMHS)
Rebecca Johnson (with Dr ES Graham, FMHS)
BBiomedSc (Hons) student
Laverne Robilliard (with Dr ES Graham, FMHS)
Director, BSc Biomedical Science
Areas of expertise
Selected publications and creative works (Research Outputs)
- Wiltshire, R., Nelson, V., Kho, D. T., Angel, C. E., O'Carroll SJ, & Graham, E. S. (2016). Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. Scientific Reports, 6, 1-13. 10.1038/srep19814
Other University of Auckland co-authors: Simon OCarroll, Scott Graham, Dan Kho
- O'Carroll SJ, Kho, D. T., Wiltshire, R., Nelson, V., Rotimi, O., Johnson, R., ... Graham, E. S. (2015). Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells. Journal of Neuroinflammation, 12, 1-18. 10.1186/s12974-015-0346-0
Other University of Auckland co-authors: Scott Graham, Simon OCarroll, Lola Mugisho, Dan Kho
- Park, S. M., Angel, C. E., McIntosh, J. D., Brooks, A. E., Middleditch, M., Chen, C. J., ... Rod Dunbar, P. (2014). Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. European Journal of Immunology, 44 (8), 2425-2436. 10.1002/eji.201344158
Other University of Auckland co-authors: Julie McIntosh, Rod Dunbar, Anna Brooks, Kathy Ruggiero, Chun-Jen Jennifer Chen
- Park, S. M., Angel, C. E., McIntosh, J. D., Mansell, C. M., Chen, C. J. J., Cebon, J., & Dunbar, P. R. (2014). Mapping the Distinctive Populations of Lymphatic Endothelial Cells in Different Zones of Human Lymph Nodes. PLoS One, 9 (4), 1-10. 10.1371/journal.pone.0094781
Other University of Auckland co-authors: Julie McIntosh, Rod Dunbar, Chun-Jen Jennifer Chen
- Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., ... Jeet, V. (2010). Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. JOURNAL OF EXPERIMENTAL MEDICINE, 207 (6), 1247-1260. 10.1084/jem.20092140
Other University of Auckland co-authors: Rod Dunbar, Chun-Jen Jennifer Chen
- Angel, C. E., Chen, C.-J. J., Horlacher, O. C., Winkler, S., John, T., Browning, J., ... Dunbar, P. R. (2009). Distinctive localization of antigen-presenting cells in human lymph nodes. BLOOD, 113 (6), 1257-1267. 10.1182/blood-2008-06-165266
Other University of Auckland co-authors: Rod Dunbar
- Angel, C. E., Lala, A., Chen, C.-J. J., Edgar, S. G., Ostrovsky, L. L., & Dunbar, P. R. (2007). CD14(+) antigen-presenting cells in human dermis are less mature than their CD1a(+) counterparts. INTERNATIONAL IMMUNOLOGY, 19 (11), 1271-1279. 10.1093/intimm/dxm096
Other University of Auckland co-authors: Rod Dunbar, Stephen Edgar
- Angel, C. E., George, E., Brooks, A. E. S., Ostrovsky, L. L., Brown, T. L. H., & Dunbar, P. R. (2006). Cutting edge: CD1a(+) antigen-presenting cells in human dermis respond rapidly to CCR7 Ligands. JOURNAL OF IMMUNOLOGY, 176 (10), 5730-5734.
Other University of Auckland co-authors: Rod Dunbar, Anna Brooks