Dr Chris Hedges
BSc (1st class Honours, Sport and Exercise Science) - University of Auckland; PhD - Victoria University (Melbourne)
Chris completed a Bachelor of Science with first class honours at the University of Auckland, before accepting an Australian Postgraduate Award and moving to Victoria University in Melbourne for his PhD studies. Following completion of his PhD studies, Chris returned to Auckland to work with Dr Tony Hickey of the School of Biological Sciences, as part of the Applied Surgery and Metabolism Laboratory.
Chris is now part of the Department of Nutrition in the Faculty of Medical and Health Sciences, where he is investigating the role of insulin signalling in the process of healthy aging, under the supervision of Dr. Troy Merry.
Research | Current
Current research projects involve:
Investigating insulin signalling in the process of healthy aging, funded by the Health Research Council.
Investigating markers of mitochondrial adaptation to exercise in humans, funded by a grant-in-aid from the Maurice and Phyllis Paykell Trust.
Investigating susbtrate metabolism in bumblebee flight muscle.
Areas of expertise
- Mitochondrial function
- Intracellular signaling pathways for mitochondrial biogenesis
- Skeletal muscle reactive oxygen species metabolism
- Skeletal muscle substrate metabolism
Selected publications and creative works (Research Outputs)
- Woodhead, J. S. T., D'Souza RF, Hedges, C. P., Wan, J., Berridge, M. V., Cameron-Smith, D., ... Merry, T. L. (2020). High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. Journal of applied physiology (Bethesda, Md. : 1985), 128 (5), 1346-1354. 10.1152/japplphysiol.00032.2020
Other University of Auckland co-authors: David Cameron-Smith, Troy Merry, Randall D'Souza
- Merry, T. L., Hedges, C. P., Masson, S. W., Laube, B., Pöhlmann D, Wueest, S., ... Konrad, D. (2020). Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease. Nature communications, 11 (1)10.1038/s41467-020-15623-z
Other University of Auckland co-authors: Troy Merry
- D'Souza RF, Woodhead, J. S. T., Hedges, C. P., Zeng, N., Wan, J., Kumagai, H., ... Mitchell, C. J. (2020). Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging, 12 (6), 5244-5258. 10.18632/aging.102944
Other University of Auckland co-authors: David Cameron-Smith, Troy Merry
- Merry, T. L., MacRae, C., Pham, T., Hedges, C. P., & Ristow, M. (2019). Deficiency in the ROS-sensing Nuclear Factor Erythroid 2-like 2 (Nrf2) causes altered glucose and lipid homeostasis following exercise training. American Journal of Physiology - Cell Physiology10.1152/ajpcell.00426.2019
Other University of Auckland co-authors: Troy Merry, Caitlin Macrae, Toan Pham
- Hedges, C. P., Bishop, D. J., & Hickey, A. J. R. (2019). Voluntary wheel running prevents the acidosis-induced decrease in skeletal muscle mitochondrial reactive oxygen species emission. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (4), 4996-5004. 10.1096/fj.201801870r
Other University of Auckland co-authors: Tony Hickey
- Hedges, C. P., Wilkinson, R. T., Devaux, J. B. L., & Hickey, A. J. R. (2019). Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 230, 115-121. 10.1016/j.cbpa.2019.01.002
Other University of Auckland co-authors: Jules Devaux, Tony Hickey
- Hedges, C. P., Woodhead, J. S. T., Wang, H. W., Mitchell, C. J., Cameron-Smith, D., Hickey, A. J. R., & Merry, T. L. (2019). Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men. Journal of applied physiology (Bethesda, Md. : 1985), 126 (2), 454-461. 10.1152/japplphysiol.00777.2018
Other University of Auckland co-authors: Troy Merry, David Cameron-Smith, Tony Hickey
- D'Souza RF, Zeng, N., Markworth, J. F., Figueiredo, V. C., Hedges, C. P., Petersen, A. C., ... Mitchell, C. J. (2019). Whey Protein Supplementation Post Resistance Exercise in Elderly Men Induces Changes in Muscle miRNA's Compared to Resistance Exercise Alone. Frontiers in nutrition, 610.3389/fnut.2019.00091
Other University of Auckland co-authors: David Cameron-Smith, Randall D'Souza