Dr Clare Marie Reynolds

BSc (Hons) PhD

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Senior Research Fellow

Biography

The links between obesity, insulin resistance and immune function have provided the basis for the emerging field of immuno-metabolism. While evidence of immune cell infiltration and increased expression of inflammatory mediators such as TNFα and IL-1β have provided many clues as to mechanisms through which “meta-inflammation” instigates metabolic dysfunction, there are many questions which remain unanswered, particularly in relation to developmental programming of health and disease. Despite a wide range of research in the area of developmental programming of metabolic dysfunction, the role of meta-inflammation has not been comprehensively assessed. Using my extensive expertise in adipose tissue biology and immuno-metabolism, my current research at the Liggins Institute sets out to bridge the gaps in knowledge between developmental programming and metabolic inflammation. My current focus centres on adipose tissue biology and the female reproductive system.

Currently supported by an HRC Sir Charles Hercus Research fellowship and an Emerging Researcher Research Grant

Research | Current

We are currently looking for a PhD student to examine the links between inflammation and developmental programming of female reproductive function using a well-established small animal model of maternal obesity. For further details contact c.reynolds@auckland.ac.nz 

Distinctions/Honours

Awarded an Illumina Emerging Researcher award for excellance in molecular biology (2014)

Winner of the DOHAD Society Prize for collaborative research (2015)

 

Areas of expertise

- Adipose tissue biology

- Maternal obesity

- Pregnancy

- Type 2 diabetes

- Reproductive function

- Developmental programming of health and disease

- Metabolic inflammation

Committees/Professional groups/Services

- New Zealand representative; DOHaD Society of Australia and New Zealand 

Selected publications and creative works (Research Outputs)

  • Plows, J. F., Ponnampalam, A. P., Vickers, M. H., & Reynolds, C. M. (2018). Artificial Sweeteners during Pregnancy - Impact on Maternal Metabolic Health.. Paper presented at 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego, CA. 6 March - 10 March 2018. REPRODUCTIVE SCIENCES. (pp. 2).
    Other University of Auckland co-authors: Mark Vickers
  • Segovia, S. A., Vickers, M. H., Harrison, C. J., Patel, R., Gray, C., & Reynolds, C. M. (2018). Maternal High-Fat and High-Salt Diets Have Differential Programming Effects on Metabolism in Adult Male Rat Offspring. Frontiers in nutrition, 510.3389/fnut.2018.00001
    Other University of Auckland co-authors: Mark Vickers
  • Reynolds, C. M., & Vickers, M. H. (2018). Utility of Small Animal Models of Developmental Programming. Methods in molecular biology (Clifton, N.J.), 1735, 145-163. 10.1007/978-1-4939-7614-0_8
    Other University of Auckland co-authors: Mark Vickers
  • Segovia, S., Vickers, M., & Reynolds, C. (2017). The impact of maternal obesity on inflammatory processes and consequences for later offspring health outcomes. Journal of Developmental Origins of Health and Disease, 8 (5), 529-540. 10.1017/S2040174417000204
    Other University of Auckland co-authors: Mark Vickers
  • Reynolds, C. M., Segovia, S. A., & Vickers, M. H. (2017). Experimental models of maternal obesity and neuroendocrine programming of metabolic disorders in offspring. Frontiers in Endocrinology, 810.3389/fendo.2017.00245
    Other University of Auckland co-authors: Mark Vickers
  • Reynolds, C. M., Perry, J. K., & Vickers, M. H. (2017). Manipulation of the growth hormone-insulin-like growth factor (GH-IGF) axis: A treatment strategy to reverse the effects of early life developmental programming. International Journal of Molecular Sciences, 18 (8).10.3390/ijms18081729
    Other University of Auckland co-authors: Mark Vickers, Jo Perry
  • Segovia, S. A., Vickers, M. H., Gray, C., Zhang, X. D., & Reynolds, C. M. (2017). Conjugated linoleic acid supplementation improves maternal high fat diet-induced programming of metabolic dysfunction in adult male rat offspring. Scientific Reports, 7 (1), 6663-undefined. 10.1038/s41598-017-07108-9
    Other University of Auckland co-authors: Mark Vickers
  • Albert, B. B., Vickers, M. H., Gray, C., Reynolds, C. M., Segovia, S. A., Derraik, J. G., ... Cutfield, W. S. (2017). Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring. Scientific Reports, 7.10.1038/s41598-017-05793-0
    URL: http://hdl.handle.net/2292/36101
    Other University of Auckland co-authors: Mark Vickers, Ben Albert, José Derraik, David Cameron-Smith, Paul Hofman, Wayne Cutfield

Contact details

Primary office location

2-6 PARK AVENUE - Bldg 529
Level G, Room G22
2-6 PARK AVE
GRAFTON
AUCKLAND 1023
New Zealand