Associate Professor Christian Johannes Soeller

Research | Current

Research interests

  • Biophysics
  • Biophotonics
  • Cardiac excitation-contraction coupling
  • Physiology
  • Confocal microscopy
  • Multiphoton microscopy
  • Novel optical microscopies
  • Digital deconvolution
  • Mathematical modelling
  • Nanostructured biosensors
  • Bionanotechnology

Christian is a principal investigator in the Biophysics and Biophotonics group within the department of physiology. My research focuses on the use of photonics to illuminate basic biomedical questions.

A key interest is the detailed biophysical mechanism of cardiac excitation-contraction coupling and its relationship to cardiac contractility. The approach is quantitative whenever possible and I use mathematical modelling as a way to formulate hypotheses in a fairly rigorous way to test if our observations are compatible with suggested mechanisms.

New insight in physiology (and biology in general) often results from the availability of new technologies to probe cell systems. A large thrust of my work is therefore directed at developing novel ways to visualize structure and function at ever increasing spatial and temporal resolution.

Recently I started a fruitful interdisciplinary collaboration with colleagues from chemistry and engineering that led to the creation of the Polymer Electronics Research Center (PERC) at the university. A major goal is to construct biosensors with increased sensitivity and selectivity from self-assembled nanostructures. A variety of electrical and photonics readout methodologies is used to allow interfacing with modern microelectronics.

 

Selected publications and creative works (Research Outputs)

  • Jayasinghe, I., Clowsley, A. H., Lin, R., Lutz, T., Harrison, C., Green, E., ... Soeller, C. (2018). True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors. Cell reports, 22 (2), 557-567. 10.1016/j.celrep.2017.12.045
    Other University of Auckland co-authors: David Baddeley
  • Crossman, D. J., Jayasinghe, I. D., & Soeller, C. (2017). Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma?. Biophysical reviews, 9 (6), 919-929. 10.1007/s12551-017-0273-7
    Other University of Auckland co-authors: David Crossman
  • Jeynes, J. C. G., Geraki, K., Jeynes, C., Zhaohong, M., Bettiol, A. A., Latorre, E., ... Soeller, C. (2017). Nanoscale Properties of Human Telomeres Measured with a Dual Purpose X-ray Fluorescence and Super Resolution Microscopy Gold Nanoparticle Probe. ACS nano10.1021/acsnano.7b07064
  • Jones, R. A., Harrison, C., Eaton, S. L., Llavero Hurtado, M., Graham, L. C., Alkhammash, L., ... Simpson, H. (2017). Cellular and Molecular Anatomy of the Human Neuromuscular Junction. Cell reports, 21 (9), 2348-2356. 10.1016/j.celrep.2017.11.008
  • Crossman, D. J., Shen, X., Jüllig M, Munro, M., Hou, Y., Middleditch, M., ... Dos Remedios, C. G. (2017). Increased collagen within the transverse tubules in human heart failure. Cardiovascular research, 113 (8), 879-891. 10.1093/cvr/cvx055
    Other University of Auckland co-authors: David Crossman, Mia Jullig, David Baddeley, Martin Middleditch
  • Goodman, L., Baddeley, D., Ambroziak, W., Waites, C. L., Garner, C. C., Soeller, C., & Montgomery, J. M. (2017). N-terminal SAP97 isoforms differentially regulate synaptic structure and postsynaptic surface pools of AMPA receptors. Hippocampus, 27 (6), 668-682. 10.1002/hipo.22723
    Other University of Auckland co-authors: Johanna Montgomery, David Baddeley, Lucy Goodman
  • Lin, R., Clowsley, A. H., Jayasinghe, I. D., Baddeley, D., & Soeller, C. (2017). Algorithmic corrections for localization microscopy with sCMOS cameras - characterisation of a computationally efficient localization approach. Optics Express, 25 (10), 11701-11716. 10.1364/oe.25.011701
    Other University of Auckland co-authors: David Baddeley
  • Munro, M. L., & Soeller, C. (2016). Early transverse tubule development begins in utero in the sheep heart. Journal of muscle research and cell motility, 37 (6), 195-202. 10.1007/s10974-016-9462-4

Contact details

Primary location

M&HS BUILDING 503 - Bldg 503
Level 4, Room 401E
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand