Associate Professor Christian Johannes Soeller

Research | Current

Research interests

  • Biophysics
  • Biophotonics
  • Cardiac excitation-contraction coupling
  • Physiology
  • Confocal microscopy
  • Multiphoton microscopy
  • Novel optical microscopies
  • Digital deconvolution
  • Mathematical modelling
  • Nanostructured biosensors
  • Bionanotechnology

Christian is a principal investigator in the Biophysics and Biophotonics group within the department of physiology. My research focuses on the use of photonics to illuminate basic biomedical questions.

A key interest is the detailed biophysical mechanism of cardiac excitation-contraction coupling and its relationship to cardiac contractility. The approach is quantitative whenever possible and I use mathematical modelling as a way to formulate hypotheses in a fairly rigorous way to test if our observations are compatible with suggested mechanisms.

New insight in physiology (and biology in general) often results from the availability of new technologies to probe cell systems. A large thrust of my work is therefore directed at developing novel ways to visualize structure and function at ever increasing spatial and temporal resolution.

Recently I started a fruitful interdisciplinary collaboration with colleagues from chemistry and engineering that led to the creation of the Polymer Electronics Research Center (PERC) at the university. A major goal is to construct biosensors with increased sensitivity and selectivity from self-assembled nanostructures. A variety of electrical and photonics readout methodologies is used to allow interfacing with modern microelectronics.

 

Selected publications and creative works (Research Outputs)

  • Goodman, L., Baddeley, D., Ambroziak, W., Waites, C. L., Garner, C. C., Soeller, C., & Montgomery, J. M. (2017). N-terminal SAP97 isoforms differentially regulate synaptic structure and postsynaptic surface pools of AMPA receptors. Hippocampus, 27 (6), 668-682. 10.1002/hipo.22723
    Other University of Auckland co-authors: Johanna Montgomery, David Baddeley, Lucy Goodman
  • Munro, M. L., & Soeller, C. (2016). Early transverse tubule development begins in utero in the sheep heart. Journal of muscle research and cell motility, 37 (6), 195-202. 10.1007/s10974-016-9462-4
  • Munro, M. L., Jayasinghe, I. D., Wang, Q., Quick, A., Wang, W., Baddeley, D., ... Soeller, C. (2016). Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. Journal of cell science, 129 (23), 4388-4398. 10.1242/jcs.196873
    Other University of Auckland co-authors: David Baddeley
  • Jayasinghe, I., Clowsley, A., Lutz, T., Green, E., Lin, R., di Michele, L., & Soeller, C. (2016). TRUE MOLECULAR SCALE ANALYSIS OF THE CALCIUM RELEASE MACHINERY OF THE HEART WITH ENHANCED SUPER-RESOLUTION IMAGING. Paper presented at Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR), Univ Leeds, Leeds, ENGLAND. 5 September - 6 September 2016. HEART. (pp. 2). 10.1136/heartjnl-2016-310696.7
  • Lin, R., Clowsley, A., Baddeley, D., Jayasinghe, I., & Soeller, C. (2016). Single Molecule Localisation Microscopy with sCMOS Cameras. Paper presented at 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA. 27 February - 2 March 2016. BIOPHYSICAL JOURNAL. (pp. 6).
    Other University of Auckland co-authors: David Baddeley
  • Munro, M. L., Shen, X., Ward, M., Crossman, D. J., & Soeller, C. (2016). Relationship between Multi-Scale Cardiomyocyte Organization and Function in Trabeculae of the Failing Human Heart. Paper presented at 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA. 27 February - 2 March 2016. BIOPHYSICAL JOURNAL. (pp. 1).
    Other University of Auckland co-authors: David Crossman, Marie-Louise Ward
  • Sauer, M., Soeller, C., & Hanrahan, O. (2015). Single-molecule localization microscopy comes of age: From concepts to biological impact. Science, 350 (6261), 699-699. 10.1126/science.350.6261.699-c
  • Crossman, D. J., Hou, Y., Jayasinghe, I., Baddeley, D., & Soeller, C. (2015). Combining confocal and single molecule localisation microscopy: A correlative approach to multi-scale tissue imaging. Methods (San Diego, Calif.), 88, 98-108. 10.1016/j.ymeth.2015.03.011
    Other University of Auckland co-authors: David Crossman, David Baddeley

Contact details

Primary location

M&HS BUILDING 503 - Bldg 503
Level 4, Room 401E
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand