Dr Christopher Lear

BSc (Hons) PhD University of Auckland

Research | Current

Christopher’s research primarily focuses on understanding the fetal cardiovascular adaptation to both perinatal asphyxia and infection and the subsequent long-term neural injury that occurs when these adaptations fail. In particular, he has a strong interest in finding markers that can predict the failure of fetal adaptations which will allow clinical intervention before injury develops. He has also investigated how common clinical treatments including antenatal glucocorticoids modulate the fetal adaptation to asphyxia and the evolution of brain injury. More recently he has begun to test novel treatment strategies to stimulate white matter repair and neuronal connectivity after asphyxial brain injury.

Distinctions/Honours

Vice-Chancellor’s Prize for Best Doctoral Thesis, University of Auckland
Dean of Graduate Studies List for excellence in writing a PhD thesis, University of Auckland
Faculty of Medical and Health Sciences Doctoral Publication Excellence Prize, University of Auckland
School of Medical Sciences Doctoral Publication Excellence Prize, University of Auckland
John Hubbard Prize for excellence in studies towards a PhD, Physiological Society of New Zealand
Mary Bullivant Prize, Physiological Society of New Zealand
UniServices Research Commercialisation Prize, University of Auckland
Wallath Award, University of Auckland

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Lear, C. A., Westgate, J. A., Kasai, M., Beacom, M. J., Maeda, Y., Magawa, S., ... Gunn, A. J. (2020). Parasympathetic activity is the key regulator of heart rate variability between decelerations during brief repeated umbilical cord occlusions in fetal sheep. American journal of physiology. Regulatory, integrative and comparative physiology, 319 (5), R541-R550. 10.1152/ajpregu.00186.2020
    Other University of Auckland co-authors: Alistair Gunn
  • Lear, C. A., Beacom, M. J., Kasai, M., Westgate, J. A., Galinsky, R., Magawa, S., ... Gunn, A. J. (2020). Reply to the "Letter to the Editor: Mind the gap: epistemology of heart rate variability". American journal of physiology. Regulatory, integrative and comparative physiology, 319 (3), R345-R346. 10.1152/ajpregu.00208.2020
    Other University of Auckland co-authors: Laura Bennet, Alistair Gunn
  • Lear, C. A., Kasai, M., Booth, L. C., Drury, P. P., Davidson, J. O., Maeda, Y., ... Westgate, J. A. (2020). Peripheral chemoreflex control of fetal heart rate decelerations overwhelms the baroreflex during brief umbilical cord occlusions in fetal sheep. The Journal of physiology10.1113/jp279573
    Other University of Auckland co-authors: Joanne Davidson, Laura Bennet, Alistair Gunn, Paul Drury
  • Lear, C. A., Beacom, M. J., Kasai, M., Westgate, J. A., Galinsky, R., Magawa, S., ... Gunn, A. J. (2020). Circulating catecholamines partially regulate T-wave morphology but not heart rate variability during repeated umbilical cord occlusions in fetal sheep. American journal of physiology. Regulatory, integrative and comparative physiology, 319 (1), R123-R131. 10.1152/ajpregu.00026.2020
    Other University of Auckland co-authors: Alistair Gunn, Laura Bennet
  • Disdier, C., Awa, F., Chen, X., Dhillon, S. K., Galinsky, R., Davidson, J. O., ... Stonestreet, B. S. (2020). Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain. Journal of Neuroinflammation, 17 (1)10.1186/s12974-020-01852-y
    Other University of Auckland co-authors: Joanne Davidson, Laura Bennet, Alistair Gunn, Simerdeep Dhillon
  • Dhillon, S. K., Wassink, G., Lear, C. A., Davidson, J. O., Holford, N. H. G., Gunn, A. J., & Bennet, L. (2020). The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep. International journal of molecular sciences, 21 (9).10.3390/ijms21093042
    Other University of Auckland co-authors: Guido Wassink, Joanne Davidson, Nick Holford, Laura Bennet, Alistair Gunn, Simerdeep Dhillon
  • Galinsky, R., Dhillon, S. K., Dean, J. M., Davidson, J. O., Lear, C. A., Wassink, G., ... Yuill, C. (2020). Tumor necrosis factor inhibition attenuates white matter gliosis after systemic inflammation in preterm fetal sheep. Journal of neuroinflammation, 17 (1)10.1186/s12974-020-01769-6
    Other University of Auckland co-authors: Justin Dean, Joanne Davidson, Guido Wassink, Laura Bennet, Mhoyra Fraser, Alistair Gunn, Simerdeep Dhillon
  • Lear, C. A., Kasai, M., Drury, P. P., Davidson, J. O., Miyagi, E., Bennet, L., & Gunn, A. J. (2020). Plasma vasopressin levels are closely associated with fetal hypotension and neuronal injury after hypoxia-ischemia in near-term fetal sheep. Pediatric research10.1038/s41390-020-0845-2
    Other University of Auckland co-authors: Paul Drury, Joanne Davidson, Laura Bennet, Alistair Gunn

Identifiers

Contact details

Primary office location

M&HS BUILDING 503 - Bldg 503
Level 4, Room 401J
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links