Dr Daniel Plimmer Furkert

PhD

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Senior Research Fellow

Biography

Dan gained his PhD in chemistry in 2003 (UoA), followed by NIH postdoctoral fellowships at Oregon State University (USA) working on natural product total synthesis, and then in the Dept of Pharmacy & Pharmacology at the University of Bath (UK) investigating novel opioid receptor ligands for treatment of drug abuse.

He returned to UoA in 2010 to take up his current position as team leader of Dist Prof Margaret Brimble's organicsynthesis labs.

Research | Current

Current research themes include organic synthesis directed towards natural products and drug discovery, development of improved chemical methods to access biologically relevant structures, and medicinal chemistry focused on TB, cancer and neuropharmacology.

Teaching | Current

Lectures in CHEM330, CHEM730 

Selected publications and creative works (Research Outputs)

  • Ding, X.-B., Brimble, M. A., & Furkert, D. P. (2018). Reactivity of 2-Nitropyrrole Systems: Development of Improved Synthetic Approaches to Nitropyrrole Natural Products. The Journal of organic chemistry, 83 (20), 12460-12470. 10.1021/acs.joc.8b01692
    Other University of Auckland co-authors: Margaret Brimble
  • Grant, P. S., Brimble, M. A., & Furkert, D. P. (2018). Synthesis of the Bicyclic Lactone Core of Leonuketal, Enabled by a Telescoped Diels-Alder Reaction Sequence. Chemistry, an Asian journal10.1002/asia.201800903
    Other University of Auckland co-authors: Margaret Brimble
  • Wood, J. M., Furkert, D. P., & Brimble, M. A. (2018). 2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis. Natural product reports10.1039/c8np00051d
    Other University of Auckland co-authors: Margaret Brimble
  • Siow, A., Opiyo, G., Kavianinia, I., Li, F. F., Furkert, D. P., Harris, P. W. R., & Brimble, M. A. (2018). Total Synthesis of the Highly N-Methylated Acetylene-Containing Anticancer Peptide Jahanyne. Organic letters, 20 (3), 788-791. 10.1021/acs.orglett.7b03925
    Other University of Auckland co-authors: Margaret Brimble, Iman Kavianinia, Paul Harris
  • Evans, G. L., Furkert, D. P., Abermil, N., Kundu, P., de Lange, K. M., Parker, E. J., ... Lott, J. S. (2018). Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design. Biochimica et Biophysica Acta - Proteins and Proteomics, 1866 (2), 264-274. 10.1016/j.bbapap.2017.08.018
    Other University of Auckland co-authors: Edward Baker, Shaun Lott, Margaret Brimble
  • Wood, J. M. (2018). Synthetic Studies Towards Bioactive Heterocycles: Pyrrole-2-carbaldehydes and N-Heterocyclic Amino Acids The University of Auckland. ResearchSpace@Auckland.
    URL: http://hdl.handle.net/2292/37667
  • Evans, G. L., Furkert, D. P., Abermil, N., Kundu, P., de Lange, K. M., Parker, E. J., ... Lott, J. S. (2017). Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups. Data in brief, 15, 1019-1029. 10.1016/j.dib.2017.10.051
    Other University of Auckland co-authors: Edward Baker, Shaun Lott, Margaret Brimble
  • Schumacher, C. E., Harris, P. W. R., Ding, X. B., Krause, B., Wright, T. H., Cook, G. M., ... Brimble, M. A. (2017). Synthesis and biological evaluation of novel teixobactin analogues. Organic and Biomolecular Chemistry, 15 (41), 8755-8760. 10.1039/c7ob02169k
    URL: http://hdl.handle.net/2292/44331
    Other University of Auckland co-authors: Margaret Brimble, Paul Harris, Xiaobo Ding

Contact details

Primary office location

SCIENCE CENTRE - CHEMISTRY - Bldg 301
Level 7, Room 729A
23 SYMONDS ST
AUCKLAND 1010
New Zealand