Dr Duncan McGillivray
BA/BSc (Auck), BSc(Hons) (ANU), DPhil (Oxf)
Research | Current
My research involves looking at the surface structures of biological systems using surface sensitive methods, particularly neutron and X-ray scattering. The recent commissioning of the OPAL research nuclear reactor in Sydney, and the opening of the Australian Synchrotron X-ray source in Melbourne, provide world-class facilities within easy reach of Auckland. Through measurements performed at these facilities the behaviour of surfaces – and in particular biological membranes – can be studied in detail.
- Oxidative stress on cellular membranes
Cellular membranes act as both a support and a gateway for biological cells, and achieve their multiple purposes through their complex compositions including lipids, proteins and sugars. When these membranes are attacked by oxidative stresses (e.g., free radicals) their behaviour changes, and this has been linked to a number of diseases including heart disease, Alzheimer’s and Parkinson’s. By using a simpler model membrane the relationships between the membrane damage, cellular defences and disease pathologies can be investigated. This work is also related to a study on antioxidants in foods with Prof Melton of Food Science.
- Membrane-incorporated membrane proteins
Membrane proteins – those that function through interactions with cellular membranes – are some of the most significant functional proteins in biology, but are also some of the least well understood. The complex and highly asymmetric environment in which these proteins operate makes them challenging targets for study. Using the same model membrane system on a solid support, as above, functional membrane proteins can be incorporated and studied in situ. This approach has already been used in looking at the bacterial toxin a-hemolysin, and will be extended to other related membrane proteins (in collaboration with A/Prof. Mitra, SBS) and synthetic biological materials (with Prof. Middelberg, University of Queensland).
- Other projects
- Functional foods are those that provide a health benefit beyond simple nutrition – for example cholesterol-lowering margarines. Designing functional foods relies on an understanding of their physical properties and interactions with digestive systems, which can be determined in part from their structural characteristics. With Dr Quek of Food Science work on emulsions on cholesterol-lowering food additives is underway.
- The development of sensors for biological analytes, such as DNA, is an area of much research interest. In collaboration with Dr Travas-Sejdic and Prof Williams the structural response of biosensor-type materials to analytes can be studied in response to environmental conditions.
Teaching | Current
- CHEM 100 / 100G
- CHEM 110
- CHEM 310
- CHEM 738 - Biomolecular Chemistry
- SCISCHOL 201 - Coordinator
Anyone interested in joining a research project is welcome to contact me to find out more.
Commisioner - International Union of Crystallography Small Angle Scattering Commission
Trustee - NZ Chemistry Olympiad Trust
Selected publications and creative works (Research Outputs)
- Akers, P. W., Hoai Le, N. C., Nelson, A. R. J., McKenna, M., O'Mahony C, McGillivray, D. J., ... Williams, D. E. (2017). Surface engineering of poly(methylmethacrylate): Effects on fluorescence immunoassay. Biointerphases, 12 (2)10.1116/1.4984010
Other University of Auckland co-authors: David Williams
- Akers, P. W., Dingley, A. J., Swift, S., Nelson, A. R. J., Martin, J., & McGillivray, D. J. (2017). Using Neutron Reflectometry to Characterize Antimicrobial Protein Surface Coatings. The journal of physical chemistry. B, 121 (24), 5908-5916. 10.1021/acs.jpcb.7b02886
Other University of Auckland co-authors: Simon Swift
- Xu, A. Y., Melton, L. D., Ryan, T. M., Mata, J. P., Jameson, G. B., Rekas, A., ... McGillivray, D. J. (2017). Sugar-coated proteins: the importance of degree of polymerisation of oligo-galacturonic acid on protein binding and aggregation. Soft matter, 13 (14), 2698-2707. 10.1039/c6sm02660e
Other University of Auckland co-authors: Laurence Melton
- Shahlori, R., Waterhouse, G. I. N., Darwish, T. A., Nelson, A. R. J., & McGillivray, D. J. (2017). Counting crystal clusters – a neutron reflectometry study of calcium phosphate nano-cluster adsorption at the air–liquid Interface. CrystEngComm10.1039/C7CE01303E
Other University of Auckland co-authors: Geoff Waterhouse
- Strover, L. T., McCulloch, B., Ho, V., Segalman, R., Malmström J, McGillivray, D. J., & Sejdic, J. T. (2017). Tuning the optoelectronic properties of P3EHT block copolymers by surface modification. International Journal of Nanotechnology, 14 (1/2/3/4/5/6), 540-540. 10.1504/IJNT.2017.082481
Other University of Auckland co-authors: Jenny Malmstrom, Jadranka Travas-Sejdic
- Xu, A. Y., Melton, L. D., Williams, M. A. K., & McGillivray, D. J. (2017). Protein and polysaccharide conjugates as emerging scaffolds for drug delivery systems. International Journal of Nanotechnology, 14 (1/2/3/4/5/6), 470-470. 10.1504/IJNT.2017.082468
Other University of Auckland co-authors: Laurence Melton
- Shahlori, R., Waterhouse, G. I. N., Nelson, A. R. J., & McGillivray, D. J. (2017). In-situ ellipsometric study of calcium phosphate biomineralisation on organic thin films. International Journal of Nanotechnology, 14 (1/2/3/4/5/6), 375-375. 10.1504/IJNT.2017.082457
Other University of Auckland co-authors: Geoff Waterhouse, Rayomand Shahlori
- Kirby, N., Cowieson, N., Hawley, A. M., Mudie, S. T., McGillivray, D. J., Kusel, M., ... Ryan, T. M. (2016). Improved radiation dose efficiency in solution SAXS using a sheath flow sample environment. Acta Crystallographica Section D Structural Biology, 72 (12), 1254-1266. 10.1107/S2059798316017174
- Media Contact
Associate Dean email address: email@example.com
Office hours by appointment
SCIENCE CENTRE 302 - Bldg 302
23 SYMONDS ST