Dr Erin Elizabeth Cawston

Erin Cawston, BMLSc PGDipMLSc MMLSc PhD Otago

Research | Current

My primary field of research involves the molecular pharmacology of G-protein coupled receptors (GPCR). My research to date has involved various aspects of GPCR regulation from ligand stimulation, signalling and trafficking. Additionally I have studied various family A GPCRs and gained important insights related to their diversity. In my career I aim to provide a more complete understanding of the roles of these receptors in disease, as well as enable more efficient drug discovery.

Distinctions/Honours

2013-2015       Maurice Paykel Postdoctoral Fellowship in Biomedical Science

2012    Neurological Foundation of New Zealand Repatriation Fellow

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Redmond, W. J., Cawston, E. E., Grimsey, N. L., Stuart, J., Edington, A. R., Glass, M., & Connor, M. (2016). Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB₁ receptors. British Journal of Pharmacology, 173 (1), 115-127. 10.1111/bph.13341
    Other University of Auckland co-authors: Michelle Glass, Natasha Grimsey
  • Cawston, E. E., Connor, M., Di Marzo, V., Silvestri, R., & Glass, M. (2015). Distinct temporal fingerprint for cyclic adenosine monophosphate (cAMP) signaling of indole-2-carboxamides as allosteric modulators of the cannabinoid receptors. Journal of Medicinal Chemistry, 58 (15), 5979-5988. 10.1021/acs.jmedchem.5b00579
    Other University of Auckland co-authors: Michelle Glass
  • Cawston, E. E., Di Marzo, V., Silvestri, R., & Glass, M. (10/12/2014). Signalling of indole-2-carboxamides as allosteric modulators of the cannabinoid receptors. Poster presented at ASCEPT-MPGPCR, Melbourne, Australia.
    Other University of Auckland co-authors: Michelle Glass
  • Cawston, E. E., Redmond, W. J., Breen, C. M., Grimsey, N. L., Connor, M., & Glass, M. (2013). Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol, 170 (4), 893-907. 10.1111/bph.12329
    Other University of Auckland co-authors: Natasha Grimsey, Michelle Glass
  • Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B. R., ... Miller, L. J. (2013). Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor. J Biol Chem, 288 (29), 21082-21095. 10.1074/jbc.M113.480715
  • Cawston, E. E., Lam, P. C., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., ... Abagyan, R. (2012). Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor. Journal of Biological Chemistry, 287 (22), 18618-18635. 10.1074/jbc.M111.335646
  • Cawston, E. E., Harikumar, K. G., & Miller, L. J. (2012). Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity. American Journal of Physiology - Cell Physiology, 302, C615-C627. 10.1152/ajpcell.00193.2011
  • Harikumar, K. G., Cawston, E. E., & Miller, L. J. (2011). Fluorescence polarization screening for allosteric small molecule ligands of the Cholecystokinin Receptor. ASSAY and Drug Development Technologies, 9, 394-402. 10.1089/adt.2010.0310
    URL: http://hdl.handle.net/2292/16115

Contact details

Primary office location

M&HS BUILDING 503 - Bldg 503
Level 5, Room 507
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand