Dr Erin Elizabeth Cawston

Erin Cawston, BMLSc PGDipMLSc MMLSc PhD Otago

Research | Current

My primary field of research involves the molecular pharmacology of G-protein coupled receptors (GPCR). My research to date has involved various aspects of GPCR regulation from ligand stimulation, signalling and trafficking. Additionally I have studied various family A GPCRs and gained important insights related to their diversity. In my career I aim to provide a more complete understanding of the roles of these receptors in disease, as well as enable more efficient drug discovery.

Distinctions/Honours

2013-2015       Maurice Paykel Postdoctoral Fellowship in Biomedical Science

2012    Neurological Foundation of New Zealand Repatriation Fellow

Selected publications and creative works (Research Outputs)

  • Redmond, W. J., Cawston, E. E., Grimsey, N. L., Stuart, J., Edington, A. R., Glass, M., & Connor, M. (2016). Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB₁ receptors. British Journal of Pharmacology, 173 (1), 115-127. 10.1111/bph.13341
    URL: http://hdl.handle.net/2292/42782
    Other University of Auckland co-authors: Michelle Glass, Natasha Grimsey
  • Cawston, E. E., Connor, M., Di Marzo, V., Silvestri, R., & Glass, M. (2015). Distinct temporal fingerprint for cyclic adenosine monophosphate (cAMP) signaling of indole-2-carboxamides as allosteric modulators of the cannabinoid receptors. Journal of Medicinal Chemistry, 58 (15), 5979-5988. 10.1021/acs.jmedchem.5b00579
    Other University of Auckland co-authors: Michelle Glass
  • Cawston, E. E., Di Marzo, V., Silvestri, R., & Glass, M. (10/12/2014). Signalling of indole-2-carboxamides as allosteric modulators of the cannabinoid receptors. Poster presented at ASCEPT-MPGPCR, Melbourne, Australia.
    Other University of Auckland co-authors: Michelle Glass
  • Cawston, E. E., Redmond, W. J., Breen, C. M., Grimsey, N. L., Connor, M., & Glass, M. (2013). Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol, 170 (4), 893-907. 10.1111/bph.12329
    URL: http://hdl.handle.net/2292/43718
    Other University of Auckland co-authors: Natasha Grimsey, Michelle Glass
  • Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B. R., ... Miller, L. J. (2013). Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor. J Biol Chem, 288 (29), 21082-21095. 10.1074/jbc.M113.480715
  • Cawston, E. E., Lam, P. C., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., ... Abagyan, R. (2012). Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor. Journal of Biological Chemistry, 287 (22), 18618-18635. 10.1074/jbc.M111.335646
  • Cawston, E. E., Harikumar, K. G., & Miller, L. J. (2012). Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity. American Journal of Physiology - Cell Physiology, 302, C615-C627. 10.1152/ajpcell.00193.2011
    URL: http://hdl.handle.net/2292/16114
  • Harikumar, K. G., Cawston, E. E., & Miller, L. J. (2011). Fluorescence polarization screening for allosteric small molecule ligands of the Cholecystokinin Receptor. ASSAY and Drug Development Technologies, 9, 394-402. 10.1089/adt.2010.0310
    URL: http://hdl.handle.net/2292/16115

Contact details

Primary office location

M&HS BUILDING 503 - Bldg 503
Level 5, Room 507
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand