Ms Erica Ruth Hendrikse

BSc (Hons) in Biomedical Science (First Class)

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Doctoral Candidate - Doctor of Philosophy

Biography

Currently I am a PhD student in Debbie Hay's lab, with a focus on cellular regulation of hormone receptors.

I previously worked as a research technician for an HRC-funded project, also in Debbie's lab. We investigated compounds that could modify the activity of the adrenomedullin 1 receptor, a potential target for diseases such as cancer and heart failure. 

I completed my BSc(Hons) in Biomedical Science in 2012, working on the pharmacology of the amylin receptors, also at the University of Auckland. I also have experience processing samples in a clinical trial laboratory environment.

 

Research | Current

In the molecular pharmacology lab, we work on understanding G protein-coupled receptors, cellular components that are important drug targets. I am particularly interested in the regulation of receptors, which relates to how receptors respond to their activators over time.

Selected publications and creative works (Research Outputs)

  • Hendrikse, E. R., Liew, L. P., Bower, R. L., Bonnet, M., Jamaluddin, M. A., Prodan, N., ... Smith, D. M. (2020). Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors. ACS Pharmacology & Translational Science, 3 (2), 305-320. 10.1021/acsptsci.9b00108
    Other University of Auckland co-authors: Michael Hay
  • Gingell, J. J., Rees, T. A., Hendrikse, E. R., Siow, A., Rennison, D., Scotter, J., ... Hay, D. L. (2020). Distinct Patterns of Internalization of Different Calcitonin Gene-Related Peptide Receptors. ACS Pharmacology & Translational Science, 3 (2), 296-304. 10.1021/acsptsci.9b00089
    Other University of Auckland co-authors: Margaret Brimble, Debbie Hay
  • Garelja, M. L., Au, M., Brimble, M. A., Gingell, J. J., Hendrikse, E. R., Lovell, A., ... Walker, C. S. (2020). Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors. ACS pharmacology & translational science, 3 (2), 246-262. 10.1021/acsptsci.9b00083
    Other University of Auckland co-authors: Margaret Brimble
  • Yule, L. R., Garelja, M. L., Hendrikse, E. R., Gingell, J. J., Poyner, D. R., Harris, P. W. H., ... Hay, D. L. (2019). A potent fluorescent calcitonin gene-related peptide analogue enables visualization of receptor internalization. PEPTIDE SCIENCE, 111 (6)10.1002/pep2.24126
    Other University of Auckland co-authors: Debbie Hay, Margaret Brimble, Michael Garelja, Paul Harris
  • Musa, H., Hendrikse, E. R., Brimble, M. A., Garelja, M. L., Watkins, H. A., Harris, P. W. R., & Hay, D. L. (2019). Pharmacological Characterization and Investigation of N-Terminal Loop Amino Acids of Adrenomedullin 2 That Are Important for Receptor Activation. Biochemistry, 58 (32), 3468-3474. 10.1021/acs.biochem.9b00571
    Other University of Auckland co-authors: Debbie Hay, Margaret Brimble, Michael Garelja, Paul Harris
  • Hendrikse, E. R., Bower, R. L., Hay, D. L., & Walker, C. S. (2019). Molecular studies of CGRP and the CGRP family of peptides in the central nervous system. Cephalalgia : an international journal of headache, 39 (3), 403-419. 10.1177/0333102418765787
    Other University of Auckland co-authors: Christopher Walker, Debbie Hay
  • Gingell, J. J., Hendrikse, E. R., & Hay, D. L. (2019). New Insights into the Regulation of CGRP-Family Receptors. Trends in pharmacological sciences, 40 (1), 71-83. 10.1016/j.tips.2018.11.005
    Other University of Auckland co-authors: Joseph Gingell, Debbie Hay
  • Bower, R. L., Yule, L., Rees, T. A., Deganutti, G., Hendrikse, E. R., Harris, P. W. R., ... Swierkula, K. (2018). Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin. ACS Pharmacology & Translational Science, 1 (1), 32-49. 10.1021/acsptsci.8b00002
    Other University of Auckland co-authors: Tayla Rees, Margaret Brimble, Debbie Hay

Identifiers

Contact details

Primary office location

THOMAS BUILDING - Bldg 110
Level 2, Room 284
3 SYMONDS ST
AUCKLAND CENTRAL
AUCKLAND 1010
New Zealand

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