Dr Frederik Bastiaan Pruijn

MSc, PhD

Biography

Frederik Pruijn obtained his Masters (1986) and PhD (1990) in Pharmacochemistry at the Free University, Amsterdam, The Netherlands. After a 2-year post-doc position at the Institute of Human Genetics, Free University in Amsterdam he went to New Zealand where he worked in the Department of Pharmacology and Clinical Pharmacology (1992-1994). In 1994 he joined The Experimental Oncology Group. He is Owner of the LinkedIn group Hypoxia in Cancer http://www.linkedin.com/groups?home=&gid=1897774

Research interests

Research | Current

  • ADME of novel hypoxia-selective anti-tumour drugs, incl. bioanalysis and metabolite identification (LC-MS).
  • Tissue (tumour) transport of drugs. In particular, the role of lipophilicity (logP), measured or calculated using the training features of ACD/LogP, on drug diffusion in the extravascular tumour compartment.
  • QSAR modelling of in vitro and in vivo PK and PD.
  • New 2-nitroimidazoles for detection and imaging of hypoxic cells.

Research group

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Hong, C. R., Dickson, B. D., Jaiswal, J. K., Pruijn, F. B., Hunter, F. W., Hay, M. P., ... Wilson, W. R. (2018). Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects. Biochemical Pharmacology, 156, 265-280. 10.1016/j.bcp.2018.08.027
    Other University of Auckland co-authors: Benjamin Dickson, Michael Hay, Jagdish Jaiswal, Francis Hunter, Kevin Hicks, Cho Rong Hong
  • Hong, C. R., Bogle, G., Wang, J., Patel, K., Pruijn, F. B., Wilson, W. R., & Hicks, K. O. (2018). Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures. Frontiers in pharmacology, 910.3389/fphar.2018.01013
    Other University of Auckland co-authors: Kevin Hicks, Gib Bogle, Cho Rong Hong
  • Bonnet, M., Hong, C. R., Wong, W. W., Liew, L. P., Shome, A., Wang, J., ... Anderson, R. F. (2018). Next-generation hypoxic cell radiosensitizers: Nitroimidazole alkylsulfonamides. Journal of Medicinal Chemistry, 61 (3), 1241-1254. 10.1021/acs.jmedchem.7b01678
    Other University of Auckland co-authors: Michael Hay, Lydia Liew, Way Wong, Bob Anderson, Stephen Jamieson, Kevin Hicks, Yongchuan Gu, Avik Shome, Cho Rong Hong
  • Lee, T. W., Hunter, F. W., Shome, A., Wrightson, E. L., McManaway, S. P., McIvor, N., ... Macann, A. J. (14/10/2017). Preclinical efficacy of hypoxia-activated prodrugs in patient-derived xenograft models of head and neck squamous cell carcinoma. Poster presented at New Zealand Society for Oncology Conference 2017, Auckland, New Zealand.
    Other University of Auckland co-authors: Tet Woo Lee, Francis Hunter, Avik Shome, Sarah McManaway, Moana Tercel, Stephen Jamieson
  • Gu, Y., Chang, T. T.-A., Wang, J., Jaiswal, J. K., Edwards, D., Downes, N. J., ... Hickey, A. J. (2017). Reductive metabolism influences the toxicity and pharmacokinetics of the hypoxia-targeted benzotriazine di-oxide anticancer agent SN30000 in mice. Frontiers in Pharmacology, 8, 1-16. 10.3389/fphar.2017.00531
    Other University of Auckland co-authors: Tony Hickey, Yongchuan Gu, Jagdish Jaiswal, Michael Hay, Kevin Hicks, Courtney Lynch
  • Tercel, M., Lee, H. H., Mehta, S. Y., Youte Tendoung, J.-J., Bai, S. Y., Liyanage, H. S., & Pruijn, F. B. (2017). Influence of a basic side chain on the properties of hypoxia-selective nitro analogues of the duocarmycins: Demonstration of substantial anticancer activity in combination with irradiation or chemotherapy. Journal of Medicinal Chemistry, 60 (13), 5834-5856. 10.1021/acs.jmedchem.7b00563
    Other University of Auckland co-authors: Ho Lee, Moana Tercel
  • Hong, C. R., Jaiswal, J., Dickson, B. D., Hunter, F. W., Hicks, K. O., & Wilson, W. R. (26/10/2016). Cellular pharmacology and bystander effects of the hypoxia activated prodrug evofosfamide (TH-302). Poster presented at New Zealand Society for Oncology Conference 2016, Palmerston North, New Zealand.
    Other University of Auckland co-authors: Benjamin Dickson, Cho Rong Hong, Jagdish Jaiswal, Francis Hunter, Kevin Hicks
  • Gamage, S. A., Jose, J., Harvey, M. G., Voss, L. J., Denny, W. A., Sleigh, J. W., ... Pruijn, F. B. (29/8/2016). Can we beat the ketamine tiger. Poster presented at EFMC-ISMC 2016: XXIV EFMC International Symposium on Medicinal Chemistry, Manchester, UK.
    Other University of Auckland co-authors: Swarna Gamage, Jiney Jose, Bill Denny, Jamie Sleigh

Identifiers

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 0, Room 001
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Social links

Web links