Dr Fiona Jane Radcliff

BSc (Hons) (UTas) PhD (UNSW)

Biography

Over the course of my career I have worked on several different pathogens and aspects of immunology. My PhD focused on identifying novel antigens for a vaccine against Helicobacter pylori and I then went on to do further work on H. pylori at the Institut Pasteur in Paris. After that soujourn I worked on cancer immunotherapy at the Royal Children's Hospital in Melbourne, with my primary focus on developing a dendritic cell-based vaccine. I then crossed the Tasman and worked in Biotech for several years, on a range of immunotherapies for inflammatory disease. I am now a member of John Fraser's research group in the Infection & Immunity Cluster at FMHS.

Research | Current

Staphylococcus aureus is major human pathogen, responsible for a broad spectrum of diseases from minor skin infections through to life-threatening illnesses such as toxic shock syndrome. Antibiotic resistant strains of S. aureus are becoming increasingly common in both hospital and community settings. Gaining a better understanding of how S. aureus interacts with the host immune system to either colonise or cause disease is essential for developing alternative treatment approaches. My research centres on understanding how selected virulence factors, primarily the Staphylococcal Superantigens and Staphylococcal Superantigen-Like proteins interact with the host immune system.

My research interests include:

Mechanisms of immune evasion by Staphylococcus aureus

The role of Streptococcal and Staphylococcal superantigens in disease

Models of Staphylococcal infection

Host pathogen interactions

Mucosal immunology

Models of infection

Models of inflammatory disease

Teaching | Current

BIOSCI 349: Biomedical Microbiology

MEDSCI 314: Immunology

MEDSCI 708: Advanced Immunology

Selected publications and creative works (Research Outputs)

  • Petousis-Harris, H., & Radcliff, F. J. (2019). Exploitation of Neisseria meningitidis Group B OMV Vaccines Against N-gonorrhoeae to Inform the Development and Deployment of Effective Gonorrhea Vaccines. FRONTIERS IN IMMUNOLOGY, 1010.3389/fimmu.2019.00683
    Other University of Auckland co-authors: Helen Petousis-Harris
  • Johnston, J., Hoggard, M., Biswas, K., Astudillo-García C, Radcliff, F. J., Mahadevan, M., & Douglas, R. G. (2019). Pathogen reservoir hypothesis investigated by analyses of the adenotonsillar and middle ear microbiota. International journal of pediatric otorhinolaryngology, 118, 103-109. 10.1016/j.ijporl.2018.12.030
    Other University of Auckland co-authors: James Johnston, Kristi Biswas, Carmen Astudillo Garcia, Richard Douglas
  • Vesty, A., Gear, K., Biswas, K., Radcliff, F. J., Taylor, M. W., & Douglas, R. G. (2018). Microbial and inflammatory-based salivary biomarkers of head and neck squamous cell carcinoma. CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 4 (6), 255-262. 10.1002/cre2.139
    Other University of Auckland co-authors: Kristi Biswas, Mark Taylor, Richard Douglas, Mike Taylor
  • Johnston, J., Hoggard, M., Biswas, K., Astudillo-García C, Waldvogel-Thurlow, S., Radcliff, F. J., ... Douglas, R. G. (2018). The bacterial community and local lymphocyte response are markedly different in patients with recurrent tonsillitis compared to obstructive sleep apnoea. International journal of pediatric otorhinolaryngology, 113, 281-288. 10.1016/j.ijporl.2018.07.041
    Other University of Auckland co-authors: Kristi Biswas, Carmen Astudillo Garcia, Richard Douglas, James Johnston
  • Johnston, J., Hoggard, M., Biswas, K., Astudillo-García C, Radcliff, F. J., Mahadevan, M., & Douglas, R. G. (2018). Paired analysis of the microbiota between surface tissue swabs and biopsies from pediatric patients undergoing adenotonsillectomy. International journal of pediatric otorhinolaryngology, 113, 51-57. 10.1016/j.ijporl.2018.07.024
    Other University of Auckland co-authors: Kristi Biswas, Carmen Astudillo Garcia, Richard Douglas, James Johnston
  • Hoggard, M., Waldvogel-Thurlow, S., Zoing, M., Chang, K., Radcliff, F. J., Wagner Mackenzie, B., ... Taylor, M. W. (2018). Inflammatory Endotypes and Microbial Associations in Chronic Rhinosinusitis. Frontiers in immunology, 910.3389/fimmu.2018.02065
    Other University of Auckland co-authors: Mike Taylor, Kristi Biswas, Richard Douglas, Mark Taylor
  • Langley, R. J., Ting, Y. T., Clow, F., Young, P. G., Radcliff, F. J., Choi, J. M., ... Fraser, J. D. (2017). Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors. PLoS Pathogens, 13 (9).10.1371/journal.ppat.1006549
    Other University of Auckland co-authors: Ries Langley, Paul Young, John Fraser
  • Radcliff, F. J., Clow, F., Mahadevan, M., Johnston, J., Proft, T., Douglas, R. G., & Fraser, J. D. (2017). A potential role for staphylococcal and streptococcal superantigens in driving skewing of TCR Vβ subsets in tonsillar hyperplasia. Medical Microbiology and Immunology, 206 (4), 337-346. 10.1007/s00430-017-0510-5
    URL: http://hdl.handle.net/2292/35015
    Other University of Auckland co-authors: Richard Douglas, Thomas Proft, John Fraser, James Johnston

Identifiers

Contact details

Primary office location

M&HS BUILDING 502 - Bldg 502
Level 3, Room 301
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links