Dr Fiona Jane Radcliff

BSc (Hons) (UTas) PhD (UNSW)

Biography

Over the course of my career I have worked on several different pathogens and aspects of immunology. My PhD focused on identifying novel antigens for a vaccine against Helicobacter pylori and I then went on to do further work on H. pylori at the Institut Pasteur in Paris. After that soujourn I worked on cancer immunotherapy at the Royal Children's Hospital in Melbourne, with my primary focus on developing a dendritic cell-based vaccine. I then crossed the Tasman and worked in Biotech for several years, on a range of immunotherapies for inflammatory disease. I am now a member of John Fraser's research group in the Infection & Immunity Cluster at FMHS.

Research | Current

Staphylococcus aureus is major human pathogen, responsible for a broad spectrum of diseases from minor skin infections through to life-threatening illnesses such as toxic shock syndrome. Antibiotic resistant strains of S. aureus are becoming increasingly common in both hospital and community settings. Gaining a better understanding of how S. aureus interacts with the host immune system to either colonise or cause disease is essential for developing alternative treatment approaches. My research centres on understanding how selected virulence factors, primarily the Staphylococcal Superantigens and Staphylococcal Superantigen-Like proteins interact with the host immune system.

My research interests include:

Mechanisms of immune evasion by Staphylococcus aureus

The role of Streptococcal and Staphylococcal superantigens in disease

Models of Staphylococcal infection

Host pathogen interactions

Mucosal immunology

Models of infection

Models of inflammatory disease

Teaching | Current

BIOSCI 349: Biomedical Microbiology

MEDSCI 314: Immunology

MEDSCI 708: Advanced Immunology

Selected publications and creative works (Research Outputs)

  • Langley, R. J., Ting, Y. T., Clow, F., Young, P. G., Radcliff, F. J., Choi, J. M., ... Fraser, J. D. (2017). Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors. PLoS pathogens, 13 (9)10.1371/journal.ppat.1006549
    Other University of Auckland co-authors: Ries Langley, Paul Young, John Fraser
  • Radcliff, F. J., Clow, F., Mahadevan, M., Johnston, J., Proft, T., Douglas, R. G., & Fraser, J. D. (2017). A potential role for staphylococcal and streptococcal superantigens in driving skewing of TCR Vβ subsets in tonsillar hyperplasia. Medical microbiology and immunology, 206 (4), 337-346. 10.1007/s00430-017-0510-5
    Other University of Auckland co-authors: Richard Douglas, Thomas Proft, John Fraser, James Johnston
  • Hardcastle, T., Jain, R., Radcliff, F., Waldvogel-Thurlow, S., Zoing, M., Biswas, K., & Douglas, R. (2017). The in vitro mucolytic effect of xylitol and dornase alfa on chronic rhinosinusitis mucus. International forum of allergy & rhinology10.1002/alr.21970
    Other University of Auckland co-authors: Richard Douglas, Kristi Biswas
  • Biswas, K., Chang, A., Hoggard, M., Radcliff, F., Jiang, Y., Taylor, M., ... Douglas, R. (2017). Toll-like receptor activation by sino-nasal mucus in chronic rhinosinusitis. Rhinology, 55 (1), 59-69. 10.4193/Rhin16.201
    Other University of Auckland co-authors: Yannan Jiang, Mike Taylor, Richard Douglas, Kristi Biswas
  • Jain, R., Lee, T., Hardcastle, T., Biswas, K., Radcliff, F., & Douglas, R. (2016). The in vitro effect of xylitol on chronic rhinosinusitis biofilms. RHINOLOGY, 54 (4), 323-328. 10.4193/Rhino15.380
    Other University of Auckland co-authors: Richard Douglas, Kristi Biswas
  • Radcliff, F. J., Fraser, J. D., & Proft, T. (2015). Vaccination with Streptococcus pyogenes nuclease A stimulates a high antibody response but no protective immunity in a mouse model of infection. Medical microbiology and immunology, 204 (2), 185-191. 10.1007/s00430-014-0353-2
    Other University of Auckland co-authors: Thomas Proft, John Fraser
  • Holtfreter, S., Radcliff, F. J., Grumann, D., Read, H., Johnson, S., Monecke, S., ... Bröker BM (2013). Characterization of a Mouse-Adapted Staphylococcus aureus Strain. PLoS One, 8 (9)10.1371/journal.pone.0071142
    Other University of Auckland co-authors: Siouxsie Wiles, John Fraser, Stephen Ritchie, Hannah Read
  • Lorenz, N., Clow, F., Radcliff, F. J., & Fraser, J. D. (2013). Full functional activity of SSL7 requires binding of both complement C5 and IgA. Immunol Cell Biol, 91 (7), 469-476. 10.1038/icb.2013.28
    Other University of Auckland co-authors: John Fraser

Identifiers

Contact details

Primary location

M&HS BUILDING 502 - Bldg 502
Level 3, Room 301
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

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