Associate Professor Gordon William Rewcastle

PhD

Associate Professor

In: Auckland Cancer Society Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

Gordon Rewcastle obtained his PhD in Organic Chemistry from The University of Auckland, and after post-doctoral work in the US he joined the Auckland Cancer Society Research Centre (ACSRC) as a medicinal chemist in 1980. Since then he has worked on a number of projects involving the design and synthesis of novel anticancer and antibacterial agents. He is an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery.

Research interests

Research | Current

Development of anticancer agents designed to inhibit protein kinase enzymes, particularly those of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signalling pathway

Selected publications and creative works (Research Outputs)

Gamage, S. A., Giddens, A. C., Tsang, K. Y., Flanagan, J. U., Kendall, J. D., Lee, W.-J., ... Shepherd, P. R. (2017). Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic and Medicinal Chemistry, 25 (20), 5859-5874. 10.1016/j.bmc.2017.09.025
Other University of Auckland co-authors: Swarna Gamage, Anna Giddens, Bill Denny, Jack Flanagan, Bruce Baguley, Christina Buchanan, Stephen Jamieson, Woo Lee
Rewcastle, G. W., Kolekar, S., Buchanan, C. M., Gamage, S. A., Giddens, A. C., Tsang, K. Y., ... Smith, G. C. (2017). Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors. Oncotarget, 8 (29), 47725-47740. 10.18632/oncotarget.17730
URL: http://hdl.handle.net/2292/34774
Other University of Auckland co-authors: Peter Shepherd, Christina Buchanan, Swarna Gamage, Bill Denny, Stephen Jamieson, Anna Giddens, Woo Lee
Gong, G. Q., Kendall, J. D., Dickson, J. M., Rewcastle, G. W., Buchanan, C. M., Denny, W. A., ... Flanagan, J. U. (2017). Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity. Biochemical Journal, 474 (13), 2261-2276. 10.1042/BCJ20161098
Other University of Auckland co-authors: James Dickson, Christina Buchanan, Bill Denny, Peter Shepherd, Jack Flanagan
Kendall, J., Giddens, A., Tsang, K., Marshall, E., Lill, C., Lee, W.-J., ... Yu, S. (2017). Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters, 27 (2), 187-190. 10.1016/j.bmcl.2016.11.078
URL: http://hdl.handle.net/2292/34181
Other University of Auckland co-authors: Peter Shepherd, Bill Denny, Christina Buchanan, Bruce Baguley, Stephen Jamieson, Anna Giddens, Woo Lee
Marshall, A. J., Lill, C. L., Chao, M., Kolekar, S. V., Lee, W.-J., Marshall, E. S., ... Flanagan, J. U. (2015). Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling. Bioorganic & Medicinal Chemistry, 23 (13), 3796-3808. 10.1016/j.bmc.2015.03.073
Other University of Auckland co-authors: Jack Flanagan, Peter Shepherd, Bill Denny, Bruce Baguley, Woo Lee
Denny, W. A., & Rewcastle, G. W. (2013). Inhibitors of the phosphatidylinositol 3-kinase (PI3K) pathway. In S. Neidle (Ed.) Cancer Drug Design and Discovery (pp. 449-478). London, UK: Elsevier Ltd. 10.1016/B978-0-12-396521-9.00015-2
Other University of Auckland co-authors: Bill Denny
Rewcastle, G. W., Tsang, K. Y., Gamage, S. A., & Giddens, A. C. (2013). Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy. US 8,486,939 B2 Related URL.
URL: http://hdl.handle.net/2292/21171
Other University of Auckland co-authors: Anna Giddens, Swarna Gamage
Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Giddens, A. C., & Tsang, K. Y. (2013). Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer Therapy. US 8,461,158 B2 Related URL.
URL: http://hdl.handle.net/2292/21163
Other University of Auckland co-authors: Swarna Gamage, Anna Giddens