Associate Professor Gordon William Rewcastle

PhD

Associate Professor

In: Auckland Cancer Society Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

Gordon Rewcastle obtained his PhD in Organic Chemistry from The University of Auckland, and after post-doctoral work in the US he joined the Auckland Cancer Society Research Centre (ACSRC) as a medicinal chemist in 1980. Since then he has worked on a number of projects involving the design and synthesis of novel anticancer and antibacterial agents. He is an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery.

Research interests

Research | Current

Development of anticancer agents designed to inhibit protein kinase enzymes, particularly those of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signalling pathway

Selected publications and creative works (Research Outputs)

Trevarton, A. J., Zhou, Y., Yang, D., Rewcastle, G. W., Flanagan, J. U., Braithwaite, A., ... Lasham, A. (2019). Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1. ACTA PHARMACEUTICA SINICA B, 9 (5), 997-1007. 10.1016/j.apsb.2018.12.011
URL: http://hdl.handle.net/2292/46019
Other University of Auckland co-authors: Annette Lasham, Jack Flanagan, Cristin Print
Wang, J., Gong, G. Q., Zhou, Y., Lee, W.-J., Buchanan, C. M., Denny, W. A., ... Flanagan, J. U. (2018). High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds. Acta pharmacologica Sinica, 39 (11), 1816-1822. 10.1038/s41401-018-0057-z
URL: http://hdl.handle.net/2292/43598
Other University of Auckland co-authors: Woo Lee, Christina Buchanan, Jack Flanagan, James Dickson, Bill Denny
Gamage, S. A., Giddens, A. C., Tsang, K. Y., Flanagan, J. U., Kendall, J. D., Lee, W.-J., ... Shepherd, P. R. (2017). Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic and Medicinal Chemistry, 25 (20), 5859-5874. 10.1016/j.bmc.2017.09.025
URL: http://hdl.handle.net/2292/41240
Other University of Auckland co-authors: Swarna Gamage, Anna Giddens, Bill Denny, Jack Flanagan, Christina Buchanan, Stephen Jamieson, Woo Lee
Rewcastle, G. W., Kolekar, S., Buchanan, C. M., Gamage, S. A., Giddens, A. C., Tsang, K. Y., ... Smith, G. C. (2017). Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors. Oncotarget, 8 (29), 47725-47740. 10.18632/oncotarget.17730
URL: http://hdl.handle.net/2292/34774
Other University of Auckland co-authors: Peter Shepherd, Christina Buchanan, Swarna Gamage, Bill Denny, Stephen Jamieson, Anna Giddens, Woo Lee
Gong, G. Q., Kendall, J. D., Dickson, J. M., Rewcastle, G. W., Buchanan, C. M., Denny, W. A., ... Flanagan, J. U. (2017). Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity. Biochemical Journal, 474 (13), 2261-2276. 10.1042/BCJ20161098
URL: http://hdl.handle.net/2292/43252
Other University of Auckland co-authors: James Dickson, Christina Buchanan, Bill Denny, Peter Shepherd, Jack Flanagan
Kendall, J., Giddens, A., Tsang, K., Marshall, E., Lill, C., Lee, W.-J., ... Yu, S. (2017). Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters, 27 (2), 187-190. 10.1016/j.bmcl.2016.11.078
URL: http://hdl.handle.net/2292/34181
Other University of Auckland co-authors: Peter Shepherd, Bill Denny, Christina Buchanan, Stephen Jamieson, Anna Giddens, Woo Lee
Marshall, A. J., Lill, C. L., Chao, M., Kolekar, S. V., Lee, W.-J., Marshall, E. S., ... Flanagan, J. U. (2015). Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling. Bioorganic & Medicinal Chemistry, 23 (13), 3796-3808. 10.1016/j.bmc.2015.03.073
Other University of Auckland co-authors: Jack Flanagan, Peter Shepherd, Bill Denny, Woo Lee
Denny, W. A., & Rewcastle, G. W. (2013). Inhibitors of the phosphatidylinositol 3-kinase (PI3K) pathway. In S. Neidle (Ed.) Cancer Drug Design and Discovery (pp. 449-478). London, UK: Elsevier Ltd. 10.1016/B978-0-12-396521-9.00015-2
Other University of Auckland co-authors: Bill Denny