Associate Professor Gordon William Rewcastle

PhD

Associate Professor

In: Auckland Cancer Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

Gordon Rewcastle obtained his PhD in Organic Chemistry from The University of Auckland, and after post-doctoral work in the US he joined the Auckland Cancer Society Research Centre (ACSRC) as a medicinal chemist in 1980. Since then he has worked on a number of projects involving the design and synthesis of novel anticancer and antibacterial agents. He is an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery.

Research interests

Research | Current

Development of anticancer agents designed to inhibit protein kinase enzymes, particularly those of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signalling pathway

Selected publications and creative works (Research Outputs)

Rewcastle, G. W., Kolekar, S., Buchanan, C. M., Gamage, S. A., Giddens, A. C., Tsang, K. Y., ... Smith, G. C. (2017). Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors. Oncotarget, 8 (29), 47725-47740. 10.18632/oncotarget.17730
URL: http://hdl.handle.net/2292/34774
Other University of Auckland co-authors: Christina Buchanan, Swarna Gamage, Bill Denny, Stephen Jamieson, Jackie Kendall, Anna Giddens
Kendall, J. D., Giddens, A. C., Tsang, K. Y., Marshall, E. S., Lill, C. L., Lee, W.-J., ... Yu, S. (2017). Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters, 27 (2), 187-190. 10.1016/j.bmcl.2016.11.078
URL: http://hdl.handle.net/2292/34181
Other University of Auckland co-authors: Bill Denny, Christina Buchanan, Bruce Baguley, Jackie Kendall, Stephen Jamieson, Anna Giddens
Marshall, A. J., Lill, C. L., Chao, M., Kolekar, S. V., Lee, W.-J., Marshall, E. S., ... Flanagan, J. U. (2015). Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling. Bioorganic & medicinal chemistry, 23 (13), 3796-3808. 10.1016/j.bmc.2015.03.073
Other University of Auckland co-authors: Jack Flanagan, Peter Shepherd, Bill Denny, Bruce Baguley
Kendall, J. D., Marshall, A. J., Giddens, A. C., Tsang, K. Y., Boyd, M., Frederick, R., ... Chao, M. (2014). Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: variation of the central linker group. MedChemComm, 5 (1), 41-46. 10.1039/C3MD00221G
URL: http://hdl.handle.net/2292/21649
Other University of Auckland co-authors: Anna Giddens, Bruce Baguley, Bill Denny, Christina Buchanan, Jackie Kendall, Woo Lee, Sharada Kolekar
Denny, W. A., & Rewcastle, G. W. (2013). Inhibitors of the phosphatidylinositol 3-kinase (PI3K) pathway. In S. Neidle (Ed.) Cancer Drug Design and Discovery (pp. 449-478). London, UK: Elsevier Ltd. 10.1016/B978-0-12-396521-9.00015-2
Other University of Auckland co-authors: Bill Denny
Rewcastle, G. W., Tsang, K. Y., Gamage, S. A., & Giddens, A. C. (2013). Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy. US 8,486,939 B2 Related URL.
URL: http://hdl.handle.net/2292/21171
Other University of Auckland co-authors: Anna Giddens, Swarna Gamage
Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Giddens, A. C., & Tsang, K. Y. (2013). Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer Therapy. US 8,461,158 B2 Related URL.
URL: http://hdl.handle.net/2292/21163
Other University of Auckland co-authors: Swarna Gamage, Anna Giddens
Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Kendall, J. D., Denny, W. A., Baguley, B. C., ... Kolekar, S. (2013). Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474). Eur J Med Chem, 64, 137-147. 10.1016/j.ejmech.2013.03.038
URL: http://hdl.handle.net/2292/34223
Other University of Auckland co-authors: Jack Flanagan, Peter Shepherd, Bruce Baguley, Bill Denny, Swarna Gamage, Christina Buchanan, Stephen Jamieson, Jackie Kendall, Sharada Kolekar