Dr Leon Guo-Liang Lu

PhD, Nankai


Guo-Liang (Leon) Lu obtained his PhD degree in organic chemistry from Nankai University under the supervision of Professor Li-Cheng Song. He worked as an associate professor in Hebei Normal University and visiting scholar in Hong Kong Baptist University, China before took a posdoctoral position with Professor Warren Roper FRS and Professor James Wright of the School of Chemical Sciences in the University of Auckland. He was appointed as a research fellow of the Centre in 2004 and currently his reserach interest is the development of anticancer drug including antibody drug conjugate (ADC), hypoxia activated prodrug (HAP) and metal-based drug (MBD). He has more than 60 journal articles and 4 patents published.

Areas of expertise

  • Organometallics
  • Organic Synthesis
  • Medicinal Chemistry
  • Drug Design
  • Cancer Researc

Selected publications and creative works (Research Outputs)

  • Liu, M., Sharma, M., Lu, G.-L., Yin, N., Gailani, M. A., Sreebhavan, S., & Wen, J. (2020). Preformulation studies of l-glutathione: physicochemical properties, degradation kinetics, and in vitro cytotoxicity investigations. Drug development and industrial pharmacy, 46 (5), 717-731. 10.1080/03639045.2020.1752708
    Other University of Auckland co-authors: Marvin Mengyang Liu, Manisha Sharma
  • Yan, X., Dong, Q., Li, Y., Meng, L., Hao, Z., Han, Z., ... Lin, J. (2020). Aerobic oxidation of primary benzylic amines to amides and nitriles catalyzed by ruthenium carbonyl clusters carrying N,O-bidentate ligands. Dalton transactions (Cambridge, England : 2003), 49 (11), 3480-3487. 10.1039/d0dt00045k
  • Zong, S., Liu, K., Yue, X., Hao, Z., Ma, Z., Han, Z., ... Lin, J. (2019). Ruthenium carbonyl complexes supported by pyridine-alkoxide ligands: synthesis, structure and catalytic oxidation of secondary alcohols. NEW JOURNAL OF CHEMISTRY, 43 (35), 13947-13953. 10.1039/c9nj03222c
    URL: http://hdl.handle.net/2292/48814
  • Su, D., Chen, J., Cosino, E., Dela Cruz-Chuh, J., Davis, H., Del Rosario, G., ... Kamath, A. V. (2019). Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjugate chemistry, 30 (5), 1356-1370. 10.1021/acs.bioconjchem.9b00133
    URL: http://hdl.handle.net/2292/48822
    Other University of Auckland co-authors: Moana Tercel
  • Giddens, A. C., Lee, H. H., Lu, G.-L., Miller, C. K., Guo, J., Lewis Phillips, G. D., ... Tercel, M. (2016). Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody-drug conjugates. Bioorganic & Medicinal Chemistry, 24 (22), 6075-6081. 10.1016/j.bmc.2016.09.068
    URL: http://hdl.handle.net/2292/48826
    Other University of Auckland co-authors: Moana Tercel, Ho Lee, Christian Miller, Anna Giddens
  • Lu, G., Tercel, M., Giddens, A., Lee, H., Bonnet, M., Denny, W., ... Stabenb, L. R. (2016). Arming antibodies with DNA cross-linking agents derived from the duocarmycins. Paper presented at The 24th International Symposium on Medicinal Chemistry (EFMC-ISMC-2016), Manchester, UK. 28 August - 1 September 2016. EFMC International Symposium on Medicinal Chemistry Book of Abstracts. Related URL.
    URL: http://hdl.handle.net/2292/32939
    Other University of Auckland co-authors: Moana Tercel, Anna Giddens, Bill Denny
  • Lam, P. L., Lu, G. L., Choi, K. H., Lin, Z., Kok, S. H. L., Lee, K. K. H., ... Bian, Z. X. (2016). Antimicrobial and toxicological evaluations of binuclear mercury( ii )bis(alkynyl) complexes containing oligothiophenes and bithiazoles. RSC Advances, 6 (20), 16736-16744. 10.1039/C5RA27600D
    URL: http://hdl.handle.net/2292/32453
  • Giddens, A., Bonnet, M., Lee, H., Lu, G. L., Miller, C. K., Tercel, M., ... Safina, B. (16/12/2015). Potent DNA crosslinking cytotoxins as novel payloads for ADCs. Poster presented at Pacifichem 2015, Honolulu, Hawaii, USA.
    Other University of Auckland co-authors: Anna Giddens, Ho Lee, Christian Miller, Gordon Rewcastle, Moana Tercel, Bill Denny


Contact details

Alternative contact

Work Ph (+64 9) 923 3717

Internal: 83717

Mobile: (+64) 21 868 990

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 117
New Zealand

Web links