Dr Leon Guo-Liang Lu
Guo-Liang (Leon) Lu obtained his PhD degree in organic chemistry from Nankai University under the supervision of Professor Li-Cheng Song. He worked as an associate professor in Hebei Normal University and visiting scholar in Hong Kong Baptist University, China before took a posdoctoral position with Professor Warren Roper FRS and Professor James Wright of the School of Chemical Sciences in the University of Auckland. He was appointed as a research fellow of the Centre in 2004 and currently his reserach interest is the development of anticancer drug including antibody drug conjugate (ADC), hypoxia activated prodrug (HAP) and metal-based drug (MBD). He has more than 60 journal articles and 4 patents published.
Areas of expertise
- Organic Synthesis
- Medicinal Chemistry
- Drug Design
- Cancer Researc
Selected publications and creative works (Research Outputs)
- Zong, S., Liu, K., Yue, X., Hao, Z., Ma, Z., Han, Z., ... Lin, J. (2019). Ruthenium carbonyl complexes supported by pyridine-alkoxide ligands: synthesis, structure and catalytic oxidation of secondary alcohols. NEW JOURNAL OF CHEMISTRY, 43 (35), 13947-13953. 10.1039/c9nj03222c
- Su, D., Chen, J., Cosino, E., Dela Cruz-Chuh, J., Davis, H., Del Rosario, G., ... Kamath, A. V. (2019). Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjugate chemistry, 30 (5), 1356-1370. 10.1021/acs.bioconjchem.9b00133
Other University of Auckland co-authors: Moana Tercel
- Giddens, A. C., Lee, H. H., Lu, G.-L., Miller, C. K., Guo, J., Lewis Phillips, G. D., ... Tercel, M. (2016). Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody-drug conjugates. Bioorganic & Medicinal Chemistry, 24 (22), 6075-6081. 10.1016/j.bmc.2016.09.068
Other University of Auckland co-authors: Moana Tercel, Ho Lee, Christian Miller, Anna Giddens
- Lu, G., Tercel, M., Giddens, A., Lee, H., Bonnet, M., Denny, W., ... Stabenb, L. R. (2016). Arming antibodies with DNA cross-linking agents derived from the duocarmycins. Paper presented at The 24th International Symposium on Medicinal Chemistry (EFMC-ISMC-2016), Manchester, UK. 28 August - 1 September 2016. EFMC International Symposium on Medicinal Chemistry Book of Abstracts. Related URL.
Other University of Auckland co-authors: Moana Tercel, Anna Giddens, Bill Denny
- Lam, P. L., Lu, G. L., Choi, K. H., Lin, Z., Kok, S. H. L., Lee, K. K. H., ... Bian, Z. X. (2016). Antimicrobial and toxicological evaluations of binuclear mercury( ii )bis(alkynyl) complexes containing oligothiophenes and bithiazoles. RSC Advances, 6 (20), 16736-16744. 10.1039/C5RA27600D
- Giddens, A., Bonnet, M., Lee, H., Lu, G. L., Miller, C. K., Tercel, M., ... Safina, B. (16/12/2015). Potent DNA crosslinking cytotoxins as novel payloads for ADCs. Poster presented at Pacifichem 2015, Honolulu, Hawaii, USA.
Other University of Auckland co-authors: Anna Giddens, Ho Lee, Christian Miller, Gordon Rewcastle, Moana Tercel, Bill Denny
- Flygare, J. A., Pillow, T. H., Safina, B., Verma, V., Wei, B. Q., Denny, W., ... Miller, C.. 1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment. WO 2015/023355 A1 Related URL.
Other University of Auckland co-authors: Gordon Rewcastle, Bill Denny, Anna Giddens, Ho Lee, Christian Miller, Moana Tercel
- Bonnet, M., Giddens, A. C., Lee, H. H., Lu, G. L., Tercel, M., Denny, W. A., ... Staben, L. R. (2015). DNA cross-linking agents as payloads for new generation antibody-drug conjugates for the treatment of HER-2 positive breast cancer. Paper presented at 19th European Symposium on Organic Chemistry, ESOC 2015, Lisbon, Portugal. 12 July - 16 July 2015. 19th European Symposium on Organic Chemistry: Book of Abstracts.
Other University of Auckland co-authors: Anna Giddens, Ho Lee, Moana Tercel, Bill Denny
Work Ph (+64 9) 923 3717
Mobile: (+64) 21 868 990
Primary office location
M&HS BUILDING 504 - Bldg 504
85 PARK RD