Dr Leon Guo-Liang Lu

PhD, Nankai

Biography

Guo-Liang (Leon) Lu obtained his PhD degree in organic chemistry from Nankai University under the supervision of Professor Li-Cheng Song. He worked as an associate professor in Hebei Normal University and visiting scholar in Hong Kong Baptist University, China before took a posdoctoral position with Professor Warren Roper FRS and Professor James Wright of the School of Chemical Sciences in the University of Auckland. He was appointed as a research fellow of the Centre in 2004 and currently his reserach interest is the development of anticancer drug including antibody drug conjugate (ADC), hypoxia activated prodrug (HAP) and metal-based drug (MBD), and anti-TB drugs. He has more than 70 journal articles published and 6 patents as co-inventor.    

Areas of expertise

  • Organometallics
  • Organic Synthesis
  • Medicinal Chemistry
  • Drug Design
  • Cancer Research

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Lu, G.-L., Tong, A. S. T., Conole, D., Sutherland, H. S., Choi, P. J., Franzblau, S. G., ... Denny, W. A. (2020). Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis. Bioorganic & medicinal chemistry, 28 (22)10.1016/j.bmc.2020.115784
    Other University of Auckland co-authors: Peter Choi, Bill Denny
  • Liu, M., Sharma, M., Lu, G.-L., Yin, N., Gailani, M. A., Sreebhavan, S., & Wen, J. (2020). Preformulation studies of l-glutathione: physicochemical properties, degradation kinetics, and in vitro cytotoxicity investigations. Drug development and industrial pharmacy, 46 (5), 717-731. 10.1080/03639045.2020.1752708
    URL: http://hdl.handle.net/2292/51387
    Other University of Auckland co-authors: Marvin Mengyang Liu, Manisha Sharma, Jingyuan Wen
  • Yan, X., Dong, Q., Li, Y., Meng, L., Hao, Z., Han, Z., ... Lin, J. (2020). Aerobic oxidation of primary benzylic amines to amides and nitriles catalyzed by ruthenium carbonyl clusters carrying N,O-bidentate ligands. Dalton transactions (Cambridge, England : 2003), 49 (11), 3480-3487. 10.1039/d0dt00045k
  • Liu, K., Zhang, J., Huo, S., Dong, Q., Hao, Z., Han, Z., ... Lin, J. (2020). Highly efficient oxidation of alcohols catalyzed by Ru(II) carbonyl complexes bearing salicylaldiminato ligands. INORGANICA CHIMICA ACTA, 50010.1016/j.ica.2019.119224
  • Zong, S., Liu, K., Yue, X., Hao, Z., Ma, Z., Han, Z., ... Lin, J. (2019). Ruthenium carbonyl complexes supported by pyridine-alkoxide ligands: synthesis, structure and catalytic oxidation of secondary alcohols. NEW JOURNAL OF CHEMISTRY, 43 (35), 13947-13953. 10.1039/c9nj03222c
  • Su, D., Chen, J., Cosino, E., Dela Cruz-Chuh, J., Davis, H., Del Rosario, G., ... Kamath, A. V. (2019). Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjugate chemistry, 30 (5), 1356-1370. 10.1021/acs.bioconjchem.9b00133
    Other University of Auckland co-authors: Moana Tercel
  • Giddens, A. C., Lee, H. H., Lu, G.-L., Miller, C. K., Guo, J., Lewis Phillips, G. D., ... Tercel, M. (2016). Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody-drug conjugates. Bioorganic & Medicinal Chemistry, 24 (22), 6075-6081. 10.1016/j.bmc.2016.09.068
    URL: http://hdl.handle.net/2292/48826
    Other University of Auckland co-authors: Moana Tercel, Ho Lee, Christian Miller, Anna Giddens
  • Lu, G. L., Tercel, M., Giddens, A. C., Lee, H. H., Bonnet, M., Denny, W. A., ... Stabenb, L. R. (2016). Arming antibodies with DNA cross-linking agents derived from the duocarmycins. Paper presented at EFMC International Symposium on Medicinal Chemistry, Manchester, UK. 28 August - 1 September 2016. EFMC International Symposium on Medicinal Chemistry Book of Abstracts.
    URL: http://hdl.handle.net/2292/32939
    Other University of Auckland co-authors: Moana Tercel, Anna Giddens, Bill Denny

Identifiers

Contact details

Alternative contact

Work Ph (+64 9) 923 3717

Internal: 83717

Mobile: (+64) 21 868 990

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 117
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links