Dr Hamish Scott Sutherland

Biography

Hamish completed his BSc, MSc (Hons) and PhD degrees at the University of Auckland. His research focussed on applications of organometallic chemistry to organic synthesis, under the supervision of Assoc. Prof. Paul Woodgate. Hamish then undertook postdoctoral work in organic synthesis with Prof. Russell Rodrigo at the University of Waterloo, Ontario, Canada.

Research interests

Research | Current

  • Medicinal chemistry and the applications of organometallic chemistry to organic synthesis

Selected publications and creative works (Research Outputs)

  • Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Blaser, A., Franzblau, S. G., ... Denny, W. A. (2018). Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles. Bioorganic & medicinal chemistry, 26 (8), 1797-1809. 10.1016/j.bmc.2018.02.026
    URL: http://hdl.handle.net/2292/44736
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny, Brian Palmer
  • Choi, P. J., Sutherland, H. S., Tong, A. S., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Motte, M. (2017). Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units. Bioorganic and Medicinal Chemistry Letters, 27 (23), 5190-5196. 10.1016/j.bmcl.2017.10.042
    URL: http://hdl.handle.net/2292/44451
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny, Brian Palmer
  • Tong, A. S., Choi, P. J., Blaser, A., Sutherland, H. S., Tsang, S. K., Guillemont, J., ... Van den Broeck, W. (2017). 6-cyano analogues of bedaquiline as less lipophilic and potentially safer diarylquinolines for tuberculosis. ACS Medicinal Chemistry Letters, 8 (10), 1019-1024. 10.1021/acsmedchemlett.7b00196
    URL: http://hdl.handle.net/2292/44180
    Other University of Auckland co-authors: Peter Choi, Adrian Blaser, Bill Denny, Brian Palmer
  • Choi, P. J., Tong, S. T., Denny, W. A., Palmer, B. D., Blaser, A., Conole, D., ... Upton, A. M. (7/9/2017). Synthetic studies towards the development of less lipophilic drug of bedaquiline. Poster presented at Queenstown Research Week, Rydges Hotel, Queenstown, New Zealand. National Symposium on Infectious Diseases: key opportunities and emerging therapies.
    Other University of Auckland co-authors: Peter Choi, Bill Denny, Brian Palmer, Adrian Blaser
  • Lin, Z., Bishop, K., Sutherland, H., Marlow, G., Murray, P., Denny, W., & Ferguson, L. (2016). A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells. Molecular BioSystems, 12 (3), 839-849. 10.1039/C5MB00554J
    URL: http://hdl.handle.net/2292/29052
    Other University of Auckland co-authors: Bill Denny, Lynnette Ferguson, Karen Bishop
  • Palmer, B. D., Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., ... Thompson, A. M. (2015). Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824). Journal of Medicinal Chemistry, 58 (7), 3036-3059. 10.1021/jm501608q
    URL: http://hdl.handle.net/2292/42159
    Other University of Auckland co-authors: Bill Denny, Andrew Thompson, Brian Palmer, Adrian Blaser
  • Sutherland, H. S., Hwang, I. Y., Marshall, E. S., Lindsay, B. S., Denny, W. A., Gilchrist, C., ... Kestell, P. (2012). Therapeutic reactivation of mutant p53 protein by quinazoline derivatives. Invest New Drugs, 30 (5), 2035-2045. 10.1007/s10637-011-9744-z
    Other University of Auckland co-authors: Bill Denny, Wayne Joseph
  • Blaser, A., Palmer, B. D., Sutherland, H. S., Kmentova, I., Franzblau, S. G., Wan, B., ... Denny, W. A. (2012). Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824). J Med Chem, 55 (1), 312-326. 10.1021/jm2012276
    URL: http://hdl.handle.net/2292/13801
    Other University of Auckland co-authors: Bill Denny, Andrew Thompson, Brian Palmer, Adrian Blaser

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand