Associate Professor Henry John Waldvogel
Research | Current
Henry's main area of research is the chemical neuroanatomy of the normal human brain and the changes that occur in the brain in neurodegenerative diseases particularly in Huntington's disease, but also in Parkinson's disease, Motor Neuron disease and Alzheimer's disease.
I study the cell death and neurochemical changes that occur in the human brain in neurodegenerative disease with a major interest in the inhibitory neurotransmitter receptors GABAA GABAB and glycine receptors and their associated proteins. These neyrochemicals are studied at both the regional and cellular level with high resolution light and confocal laser scanning microscopy. Tissue microarrays are also being developed.
Also animal models of Huntington's disease especially the transgenic sheep model have been developed in a large collaborative study to and our laboratory is studying the neuropathological changes in this sheep model in order to understand the mechanisms of cell death and to trial therapeutic strategies.
Selected publications and creative works (Research Outputs)
- Waldvogel, H., Dragunow, M., & Faull, R. (2015). Disrupted vasculature and blood-brain barrier in Huntington disease. Annals of Neurology, 78 (2), 158-159. 10.1002/ana.24445
Other University of Auckland co-authors: Richard Faull, Michael Dragunow
- Lowe, M. T., Faull, R. L., Christie, D. L., & Waldvogel, H. J. (2015). Distribution of the creatine transporter throughout the human brain reveals a spectrum of creatine transporter immunoreactivity. Journal of Comparative Neurology, 523 (5), 699-725. 10.1002/cne.23667
Other University of Auckland co-authors: Richard Faull, David Christie
- Waldvogel, H. J., & Faull, R. L. M. (2015). The diversity of GABA(A) receptor subunit distribution in the normal and Huntington's disease human brain. Advances in pharmacology (San Diego, Calif.), 73, 223-264. 10.1016/bs.apha.2014.11.010
Other University of Auckland co-authors: Richard Faull
- Waldvogel, H. J., Kim, E. H., Tippett, L. J., Vonsattel, J.-P. G., & Faull, R. L. M. (2015). The Neuropathology of Huntington's Disease. Current topics in behavioral neurosciences, 22, 33-80. 10.1007/7854_2014_354
Other University of Auckland co-authors: Richard Faull, Lynette Tippett
- Reid, S. J., Patassini, S., Handley, R. R., Rudiger, S. R., McLaughlan, C. J., Osmand, A., ... Waldvogel, H. J. (2013). Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates. Journal of Huntington's Disease, 2 (3), 279-295. 10.3233/JHD-130067
Other University of Auckland co-authors: Suzanne Reid, Richard Faull, Russell Snell, Renee Handley, Jessie Jacobsen
- Jacobsen, J. C., Bawden, C. S., Rudiger, S. R., McLaughlan, C. J., Reid, S. J., Waldvogel, H. J., ... Kelly, J. M. (2010). An ovine transgenic Huntington's disease model. HUMAN MOLECULAR GENETICS, 19 (10), 1873-1882. 10.1093/hmg/ddq063
Other University of Auckland co-authors: Russell Snell, Suzanne Reid, Richard Faull, Jessie Jacobsen
- Allen, K. L., Waldvogel, H. J., Glass, M., & Faull, R. L. M. (2009). Cannabinoid (CB1), GABA(A) and GABA(B) receptor subunit changes in the globus pallidus in Huntington's disease. JOURNAL OF CHEMICAL NEUROANATOMY, 37 (4), 266-281. 10.1016/j.jchemneu.2009.02.001
Other University of Auckland co-authors: Michelle Glass, Richard Faull
- Waldvogel, H. J., Baer, K., Gai, W.-P., Gilbert, R. T., Rees, M. I., Mohler, H., & Faull, R. L. M. (2008). Differential localization of GABA(A) receptor subunits within the substantia nigra of the human brain: An immunohistochemical study. JOURNAL OF COMPARATIVE NEUROLOGY, 506 (6), 912-929. 10.1002/cne.21573
Other University of Auckland co-authors: Ray Gilbert, Richard Faull