Associate Professor Ian John LeGrice
BE, DipTP, BHB, MBChB, PhD (jointly with Physiology)
Ian began his academic career with a Bachelor of Engineering in Civil Engineering from the University of Auckland, following it with a Diploma of Town Planning (DipTP). He subsequently went on to study Medicine at Auckland, obtaining his Bachelor of Human Biology (BHB), and then a Bachelor of Medicine and Bachelor of Surgery (MBChB). After briefly practicing medicine he returned to the University to obtain a PhD in Physiology.
After his PhD work on structure and electrical activation of the cardiac ventricles at the University of Auckland, Ian did his postdoctoral work on cardiac mechanics with Professor James Covell at the University of California, San Diego. After 2 years at UCSD, Ian returned to a lectureship in the Department of Physiology at the University of Auckland in 1994. In this position, Ian has had significant administrative and teaching roles in the Medical Programme.
Research | Current
Ian continues his research into the relationship between structure and function in the heart as a member of the Auckland Bioengineering Institute, closely collaborating with Bruce Smaill. This work has developed from the earlier focus on the normal cardiac function, to investigating the effects of diseases, such as hypertension and myocadial infarction, on cardiac structure and function.
Research groups and projects:
Selected publications and creative works (Research Outputs)
- Kelch, I. D., Bogle, G., Sands, G. B., Phillips, A. R. J., LeGrice, I. J., & Dunbar, P. R. (2019). High-resolution 3D imaging and topological mapping of the lymph node conduit system. PLoS biology, 17 (12)10.1371/journal.pbio.3000486
Other University of Auckland co-authors: Anthony Phillips, Inken Kelch, Gib Bogle, Gregory Sands, Rod Dunbar
- Hasaballa, A. I., Wang, V. Y., Sands, G. B., Wilson, A. J., Young, A. A., LeGrice, I. J., & Nash, M. P. (2019). Microstructurally Motivated Constitutive Modeling of Heart Failure Mechanics. Biophysical journal, 117 (12), 2273-2286. 10.1016/j.bpj.2019.09.038
Other University of Auckland co-authors: Gregory Sands, Vicky Wang, Alistair Young, Martyn Nash
- Abukar, Y., Lever, N., Pachen, M., LeGrice, I. J., & Ramchandra, R. (2019). Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations. FRONTIERS IN PHYSIOLOGY, 1010.3389/fphys.2019.01420
Other University of Auckland co-authors: Rohit Ramchandra, Nigel Lever
- Abukar, Y., LeGrice, I., Lever, N., Paton, J. F. R., & Ramchandra, R. (2019). Restoring respiratory sinus arrhythmia to improve cardiac function in ovine heart failure. ACTA PHYSIOLOGICA. (pp. 1).
Other University of Auckland co-authors: Rohit Ramchandra, Julian Paton
- Trew, M. L., Engelman, Z. J., Caldwell, B. J., Lever, N. A., LeGrice, I. J., & Smaill, B. H. (2019). Cardiac intramural electrical mapping reveals focal delays but no conduction velocity slowing in the peri-infarct region. American journal of physiology. Heart and circulatory physiology, 317 (4), H743-H753. 10.1152/ajpheart.00154.2019
Other University of Auckland co-authors: Bruce Smaill, Mark Trew, Nigel Lever
- Vigneshwaran, V., Sands, G. B., LeGrice, I. J., Smaill, B. H., & Smith, N. P. (2019). Reconstruction of coronary circulation networks: A review of methods. Microcirculation (New York, N.Y. : 1994), 26 (5)10.1111/micc.12542
Other University of Auckland co-authors: Nic Smith, Gregory Sands, Bruce Smaill
- Ashton, J. L., Trew, M. L., LeGrice, I. J., Paterson, D. J., Paton, J. F., Gillis, A. M., & Smaill, B. H. (2019). Shift of leading pacemaker site during reflex vagal stimulation and altered electrical source-to-sink balance. The Journal of physiology10.1113/jp276876
Other University of Auckland co-authors: Jesse Ashton, Julian Paton, Mark Trew, Bruce Smaill
- Ramlugun, G. S., Zhao, J., Sands, G. B., Le Grice, I. J., & Smaill, B. H. (2019). Progression of Atrial Electrical Dysfunction in Hypertensive Heart Disease. Paper presented at Heart Rhythm 40th Scientific Sessions, San Francisco, CA. 8 May - 11 May 2019. Heart Rhythm. 10.1016/j.hrthm.2019.04.020
Other University of Auckland co-authors: Gregory Sands