Associate Professor Ian John LeGrice
BE, DipTP, BHB, MBChB, PhD (jointly with Physiology)
Ian began his academic career with a Bachelor of Engineering in Civil Engineering from the University of Auckland, following it with a Diploma of Town Planning (DipTP). He subsequently went on to study Medicine at Auckland, obtaining his Bachelor of Human Biology (BHB), and then a Bachelor of Medicine and Bachelor of Surgery (MBChB). After briefly practicing medicine he returned to the University to obtain a PhD in Physiology.
After his PhD work on structure and electrical activation of the cardiac ventricles at the University of Auckland, Ian did his postdoctoral work on cardiac mechanics with Professor James Covell at the University of California, San Diego. After 2 years at UCSD, Ian returned to a lectureship in the Department of Physiology at the University of Auckland in 1994. In this position, Ian has had significant administrative and teaching roles in the Medical Programme.
Research | Current
Ian continues his research into the relationship between structure and function in the heart as a member of the Auckland Bioengineering Institute, closely collaborating with Bruce Smaill. This work has developed from the earlier focus on the normal cardiac function, to investigating the effects of diseases, such as hypertension and myocadial infarction, on cardiac structure and function.
Research groups and projects:
Selected publications and creative works (Research Outputs)
- Caldwell, B. J., Trew, M. L., Le Grice, I., & Smaill, B. (2017). Development of 3D intramural and surface potentials in the LV: microstructural basis of preferential transmural conduction. Journal of Cardiovascular Electrophysiology, 28 (6), 692-701. 10.1111/jce.13207
Other University of Auckland co-authors: Bryan Caldwell, Mark Trew, Bruce Smaill
- Ashton, J. L., Le Grice, I. J., Paterson, D. J., Paton, J. F. R., Trew, M. L., Gillis, A. M., & Smaill, B. H. (2017). Shift of dominant pacemaker site during reflex vagal stimulation is the result of propagation failure. Paper presented at Heart Rhythm Society 38th Annual Scientific Sessions, Chicago, USA. 10 May - 13 May 2017. Heart Rhythm. 10.1016/j.hrthm.2017.04.010
Other University of Auckland co-authors: Jesse Ashton, David Paterson, Mark Trew, Bruce Smaill
- Hasaballa, A. I., Sands, G. B., Wilson, A. J., Young, A. A., Wang, V. Y., LeGrice, I. J., & Nash, M. P. (2017). Three-dimensional quantification of myocardial collagen morphology from confocal images. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 10.1007/978-3-319-59448-4_1
Other University of Auckland co-authors: Gregory Sands, Alistair Young, Vicky Wang, Martyn Nash
- Wilson, A. J., Wang, V. Y., Sands, G. B., Young, A. A., Nash, M. P., & LeGrice, I. J. (2017). Increased cardiac work provides a link between systemic hypertension and heart failure. Physiological Reports, 5 (1).10.14814/phy2.13104
Other University of Auckland co-authors: Gregory Sands, Alistair Young, Martyn Nash, Vicky Wang
- Kelch, I. D., Bogle, G., Sands, G. B., Phillips, A. R. J., LeGrice, I. J., & Dunbar, P. R. (2016). 3D visualisation and comprehensive analysis of the conduit network in entire murine lymph nodes. Paper presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA. 21 August - 26 August 2016. EUROPEAN JOURNAL OF IMMUNOLOGY. (pp. 1).
Other University of Auckland co-authors: Gib Bogle, Anthony Phillips, Gregory Sands, Inken Kelch, Rod Dunbar
- Wang, V. Y., Niestrawska, J. A., Wilson, A. J., Sands, G. B., Young, A. A., LeGrice, I. J., & Nash, M. P. (2016). Image-driven constitutive modeling of myocardial fibrosis. International Journal for Computational Methods in Engineering Science and Mechanics, 17 (3), 211-221. 10.1080/15502287.2015.1082675
Other University of Auckland co-authors: Alistair Young, Martyn Nash, Vicky Wang, Gregory Sands
- Kelch, I. D., Bogle, G., Sands, G. B., Phillips, A. R. J., LeGrice, I. J., & Dunbar, P. R. (2016). Corrigendum: Organ-wide 3D-imaging and topological analysis of the continuous microvascular network in a murine lymph node. Scientific reports, 610.1038/srep20294
Other University of Auckland co-authors: Rod Dunbar, Gib Bogle, Gregory Sands, Anthony Phillips
- Freytag, B., Wang, V. Y., Christie, G. R., Wilson, A. J., Sands, G. B., Legrice, I. J., ... Nash, M. P. (2016). Parameterisation of multi-directional diffusion weighted magnetic resonance images of the heart. Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges. Lecture Notes in Computer Science, 9534, 60-68. Munich: Springer Verlag. 10.1007/978-3-319-28712-6_7
Other University of Auckland co-authors: Richard Christie, Alistair Young, Vicky Wang, Gregory Sands, Martyn Nash, Bianca Freytag