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Dr Jonathan William Astin
BSc (Hons), PhD
Research | Current
My research focuses on understanding how vascular development is regulated. My research utilises the zebrafish model of vertebrate development which has transgenic tools that allow us to visualise the developing lymphatic and blood vessels. We couple high-resolution in vivo imaging with both forward and reverse genetics, to uncover how blood and lymphatic vessels form in the developing embryo.
Recent research highlights:
1) Producing the first "atlas" describing all the lymphatic vessels in the zebrafish larvae
2) Identifying a new mechanism of lymphatic vessel development involving a non-venous lymphatic progenitor.
Teaching | Current
BIOMED 399 Biomedical Science Capstone (Co-Course Director)
BIOSCI 356 Developmental Biology and Cancer
MEDSCI 301 Molecular Basis of Disease
MEDSCI 302 Cancer Biology
MEDSCI 704 Stem Cells and Development (Course Director)
MEDSCI 720 Biomedical Research Techniques
Postgraduate supervision
Denver Britto - PhD candidate
Wenxuan Chen - PhD candidate
Areas of expertise
Developmental Biology
Vascular Biology
Cell Migration
Genetics
Zebrafish
Committees/Professional groups/Services
North American Vascular Biology Organisation (NAVBO)
Australia and New Zealand Society for Cell and Developmental Biology (ANZSCDB)
Selected publications and creative works (Research Outputs)
- Eng, T. C., Chen, W., Okuda, K. S., Misa, J. P., Padberg, Y., Crosier, K. E., ... Hogan, B. M. (2019). Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports, 20 (5).10.15252/embr.201847079
Other University of Auckland co-authors: Wenxuan Chen, Kathryn Crosier, Philip Crosier, Christopher Hall - Britto, D. D., Wyroba, B., Chen, W., Lockwood, R. A., Tran, K. B., Shepherd, P. R., ... Astin, J. W. (2018). Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Disease Models & Mechanisms, 11 (12)10.1242/dmm.035998
Other University of Auckland co-authors: Khanh Tran, Christopher Hall, Kathryn Crosier, Philip Crosier, Wenxuan Chen - Hall, C. J., Sanderson, L. E., Lawrence, L. M., Pool, B., van der Kroef, M., Ashimbayeva, E., ... Astin, J. W. (2018). Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. The Journal of clinical investigation, 128 (5), 1752-1771. 10.1172/JCI94584
Other University of Auckland co-authors: Nicola Dalbeth, Christopher Hall, Philip Crosier, Kathryn Crosier - Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., ... Shin, M. (2015). Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature, 522 (7554), 56-61. 10.1038/nature14425
Other University of Auckland co-authors: Philip Crosier - Astin, J., Jamieson, S., Eng, T., Flores, M., Misa, J., Chien, A., ... Crosier, P. (2014). An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis. Molecular Cancer Therapeutics, 13 (10), 2450-2462. 10.1158/1535-7163.mct-14-0469-t
Other University of Auckland co-authors: Philip Crosier, Kathryn Crosier, Stephen Jamieson - Astin, J. W., Haggerty, M. J. L., Okuda, K. S., Le Guen, L., Misa, J. P., Tromp, A., ... Crosier, P. S. (2014). Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting. Development, 141 (13), 2680-2690. 10.1242/dev.106591
Other University of Auckland co-authors: Philip Crosier, Kathryn Crosier - Coxam, B., Sabine, A., Bower, N. I., Smith, K. A., Pichol-Thievend, C., Skoczylas, R., ... Crosier, P. S. (2014). Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep, 7 (3), 623-633. 10.1016/j.celrep.2014.03.063
Other University of Auckland co-authors: Philip Crosier - Okuda, K. S., Astin, J. W., Misa, J. P., Flores, M. V., Crosier, K. E., & Crosier, P. S. (2012). lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish. Development, 139 (13), 2381-2391. 10.1242/dev.077701
Other University of Auckland co-authors: Philip Crosier, Kathryn Crosier
Identifiers
Contact details
- +64 9 923 4480
- +64.9.923.4480
- j.astin@auckland.ac.nz
- jast141@aucklanduni.ac.nz
Primary office location
M&HS BUILDING 504 - Bldg 504
Level 3, Room 323
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand