Dr Jonathan William Astin

BSc (Hons), PhD

Research | Current

My research focuses on understanding how vascular development is regulated. My research utilises the zebrafish model of vertebrate development which has transgenic tools that allow us to visualise the developing lymphatic and blood vessels. We couple high-resolution in vivo imaging with both forward and reverse genetics, to uncover how blood and lymphatic vessels form in the developing embryo.

Recent research highlights:

1) Producing the first "atlas" describing all the lymphatic vessels in the zebrafish larvae

2) Identifying a new mechanism of lymphatic vessel development involving a non-venous lymphatic progenitor.

Teaching | Current

BIOMED 399 Biomedical Science Capstone (Co-Course Director)

BIOSCI 356 Developmental Biology and Cancer

MEDSCI 301 Molecular Basis of Disease

MEDSCI 302 Cancer Biology

MEDSCI 704 Stem Cells and Development (Course Director)

MEDSCI 720 Biomedical Research Techniques

Postgraduate supervision

Denver Britto - PhD candidate

Wenxuan Chen - PhD candidate

Areas of expertise

Developmental Biology

Vascular Biology

Cell Migration

Genetics

Zebrafish

Committees/Professional groups/Services

North American Vascular Biology Organisation (NAVBO)

Australia and New Zealand Society for Cell and Developmental Biology (ANZSCDB)

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Eng, T. C., Chen, W., Okuda, K. S., Misa, J. P., Padberg, Y., Crosier, K. E., ... Hogan, B. M. (2019). Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports, 20 (5).10.15252/embr.201847079
    Other University of Auckland co-authors: Wenxuan Chen, Kathryn Crosier, Philip Crosier, Christopher Hall
  • Britto, D. D., Wyroba, B., Chen, W., Lockwood, R. A., Tran, K. B., Shepherd, P. R., ... Astin, J. W. (2018). Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Disease Models & Mechanisms, 11 (12)10.1242/dmm.035998
    Other University of Auckland co-authors: Khanh Tran, Christopher Hall, Kathryn Crosier, Philip Crosier, Wenxuan Chen
  • Hall, C. J., Sanderson, L. E., Lawrence, L. M., Pool, B., van der Kroef, M., Ashimbayeva, E., ... Astin, J. W. (2018). Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. The Journal of clinical investigation, 128 (5), 1752-1771. 10.1172/JCI94584
    Other University of Auckland co-authors: Nicola Dalbeth, Christopher Hall, Philip Crosier, Kathryn Crosier
  • Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., ... Shin, M. (2015). Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature, 522 (7554), 56-61. 10.1038/nature14425
    Other University of Auckland co-authors: Philip Crosier
  • Astin, J., Jamieson, S., Eng, T., Flores, M., Misa, J., Chien, A., ... Crosier, P. (2014). An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis. Molecular Cancer Therapeutics, 13 (10), 2450-2462. 10.1158/1535-7163.mct-14-0469-t
    Other University of Auckland co-authors: Philip Crosier, Kathryn Crosier, Stephen Jamieson
  • Astin, J. W., Haggerty, M. J. L., Okuda, K. S., Le Guen, L., Misa, J. P., Tromp, A., ... Crosier, P. S. (2014). Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting. Development, 141 (13), 2680-2690. 10.1242/dev.106591
    Other University of Auckland co-authors: Philip Crosier, Kathryn Crosier
  • Coxam, B., Sabine, A., Bower, N. I., Smith, K. A., Pichol-Thievend, C., Skoczylas, R., ... Crosier, P. S. (2014). Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep, 7 (3), 623-633. 10.1016/j.celrep.2014.03.063
    Other University of Auckland co-authors: Philip Crosier
  • Okuda, K. S., Astin, J. W., Misa, J. P., Flores, M. V., Crosier, K. E., & Crosier, P. S. (2012). lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish. Development, 139 (13), 2381-2391. 10.1242/dev.077701
    Other University of Auckland co-authors: Philip Crosier, Kathryn Crosier

Identifiers

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 3, Room 323
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links