Dr Jonathan William Astin

BSc (Hons), PhD

Research | Current

My research focuses on understanding how vascular development is regulated. My research utilises the zebrafish model of vertebrate development which has transgenic tools that allow us to visualise the developing lymphatic and blood vessels. We couple high-resolution in vivo imaging with both forward and reverse genetics, to uncover how blood and lymphatic vessels form in the developing embryo.

Recent research highlights:

1) Producing the first "atlas" describing all the lymphatic vessels in the zebrafish larvae

2) Identifying a new mechanism of lymphatic vessel development involving a non-venous lymphatic progenitor.

Teaching | Current

BIOSCI 356 Developmental Biology and Cancer

MEDSCI 301 Molecular Basis of Disease

MEDSCI 302 Cancer Biology

MEDSCI 704 Stem Cells and Development (Course Director)

MEDSCI 720 Biomedical Research Techniques

Postgraduate supervision

Denver Britto - PhD candidate

Annie Yang - MBiomedSc candidate

Janet Reid - BBiomedSc(Hons) candidate

Areas of expertise

Developmental Biology

Vascular Biology

Cell Migration

Genetics

Zebrafish

Committees/Professional groups/Services

North American Vascular Biology Organisation (NAVBO)

Australia and New Zealand Society for Cell and Developmental Biology (ANZSCDB)

Selected publications and creative works (Research Outputs)

  • Eng, T. C., Chen, W., Okuda, K. S., Misa, J. P., Padberg, Y., Crosier, K. E., ... Hogan, B. M. (2019). Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports, 20 (5).10.15252/embr.201847079
    Other University of Auckland co-authors: Wenxuan Chen, Christopher Hall
  • Britto, D. D., Wyroba, B., Chen, W., Lockwood, R. A., Tran, K. B., Shepherd, P. R., ... Astin, J. W. (2018). Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Disease Models & Mechanisms, 11 (12)10.1242/dmm.035998
    URL: http://hdl.handle.net/2292/46170
    Other University of Auckland co-authors: Khanh Tran, Christopher Hall, Wenxuan Chen
  • Hall, C. J., Sanderson, L. E., Lawrence, L. M., Pool, B., van der Kroef, M., Ashimbayeva, E., ... Astin, J. W. (2018). Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. The Journal of clinical investigation, 128 (5), 1752-1771. 10.1172/JCI94584
    URL: http://hdl.handle.net/2292/43037
    Other University of Auckland co-authors: Nicola Dalbeth, Christopher Hall
  • Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., ... Shin, M. (2015). Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature, 522 (7554), 56-61. 10.1038/nature14425
  • Astin, J., Jamieson, S., Eng, T., Flores, M., Misa, J., Chien, A., ... Crosier, P. (2014). An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis. Molecular Cancer Therapeutics, 13 (10), 2450-2462. 10.1158/1535-7163.mct-14-0469-t
    URL: http://hdl.handle.net/2292/34200
    Other University of Auckland co-authors: Stephen Jamieson
  • Astin, J. W., Haggerty, M. J. L., Okuda, K. S., Le Guen, L., Misa, J. P., Tromp, A., ... Crosier, P. S. (2014). Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting. Development, 141 (13), 2680-2690. 10.1242/dev.106591
  • Coxam, B., Sabine, A., Bower, N. I., Smith, K. A., Pichol-Thievend, C., Skoczylas, R., ... Crosier, P. S. (2014). Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep, 7 (3), 623-633. 10.1016/j.celrep.2014.03.063
  • Okuda, K. S., Astin, J. W., Misa, J. P., Flores, M. V., Crosier, K. E., & Crosier, P. S. (2012). lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish. Development, 139 (13), 2381-2391. 10.1242/dev.077701

Identifiers

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links