Dr Jules Bertrand Luc Devaux
PhD, MSc, BSc
Research | Current
I am currently research technician for the Motor Neuron and Disease Lab at the Centre for Brain Research.
My principal activity is the coordination, in part, of the studies led by Dr. Emma Scotter:
- “Genetic Screening of people living with Motor Neuron Disease”
- “Using MRI to investigate blood-brain barrier leakage in Motor Neuron Disease”
My past research and general interest are peaked by the mitochondrial function and dysfunction.
My PhD assessed the mitochondrial adaptations that marine species (benthic fish and sharks) have evolved to inhabit environments subjected to intermittent hypoxia.
I have also been involved in studies assessing the effect of altitude, acidosis, temperature and exercise using various models (murine, fish, insects, human derived cell lines).
Within the ASML Lab and the mentoring of Associate Professor Tony Hickey (School of Biological Sciences), I have helped for the development and optimisation of assays to test the mitochondrial fitness. Using high resolution respirometers coupled with purposed designed fluorimeter we tackled various aspect of th mitochondrial function and this includes oxygen consumption, reactive oxygen species generation, ATP production, membrane potential regulation, redox balance, substrate utilisation, calcium handling and pH buffering.
Areas of expertise
Mitochondrial physiology, respirometry, fluorimetry, spectrophotometry.
Selected publications and creative works (Research Outputs)
- Farhat, F., Simon, B., Amerand, A., Devaux, J., Belhomme, M., Calves, P., & Moisan, C. (2020). Exercise training changes mitochondrial function and its vulnerability to reactive oxygen species exposure differently in male and female silver European eels. ENVIRONMENTAL BIOLOGY OF FISHES, 103 (4), 363-375. 10.1007/s10641-020-00962-z
- Hunter, F. W., Devaux, J. B. L., Meng, F., Hong, C. R., Khan, A., Tsai, P., ... Marastoni, S. (2019). Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide. Molecular pharmacology, 95 (6), 638-651. 10.1124/mol.118.115196
Other University of Auckland co-authors: Francis Hunter, Stefan Bohlander, Peter Tsai, Purvi Kakadiya, Tony Hickey, Cristin Print
- Horscroft, J. A., O'Brien KA, Clark, A. D., Lindsay, R. T., Steel, A. S., Procter, N. E. K., ... Murray, A. J. (2019). Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (6), 7563-7577. 10.1096/fj.201900067R
- Hedges, C. P., Wilkinson, R. T., Devaux, J. B. L., & Hickey, A. J. R. (2019). Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 230, 115-121. 10.1016/j.cbpa.2019.01.002
Other University of Auckland co-authors: Chris Hedges, Tony Hickey
- O'Brien KA, Horscroft, J. A., Devaux, J., Lindsay, R. T., Steel, A. S., Clark, A. D., ... Murray, A. J. (2019). PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia. Biochimica et biophysica acta. Molecular basis of disease, 1865 (4), 844-853. 10.1016/j.bbadis.2018.07.027
- Devaux, J. B. L., Hickey, A. J. R., & Renshaw, G. M. C. (2019). Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/re-oxygenation. The Journal of experimental biology, 222 (Pt 6).10.1242/jeb.191353
Other University of Auckland co-authors: Tony Hickey
- Devaux, J. B. (2019). Mitochondrial adaptations involved in hypoxia and anoxia-tolerance of intertidal fish The University of Auckland. ResearchSpace@Auckland.
- Devaux, J. B. L., Hedges, C. P., Birch, N., Herbert, N., Renshaw, G. M. C., & Hickey, A. J. R. (2018). Acidosis Maintains the Function of Brain Mitochondria in Hypoxia-Tolerant Triplefin Fish: A Strategy to Survive Acute Hypoxic Exposure?. Frontiers in physiology, 910.3389/fphys.2018.01941
Other University of Auckland co-authors: Tony Hickey, Chris Hedges, Neill Herbert