Dr Jules Bertrand Luc Devaux
PhD, MSc, BSc
Research | Current
My research and general interest are peaked by the mitochondrial function and dysfunction.
Currently, my research fellowship focusses on the effect of temperature on the mitochondrial function in fish heart.
2019-2021: Research technician for the Motor Neuron and Disease Lab at the Centre for Brain Research.
My principal activity was the coordination, in part, of the studies led by Dr. Emma Scotter:
- “Genetic Screening of people living with Motor Neuron Disease”
- “Using MRI to investigate blood-brain barrier leakage in Motor Neuron Disease”
2015-2019: PhD "Mitochondrial function involved in hypoxia and anoxia-tolerance of intertidal fish"
I have also been involved in studies assessing the effect of altitude, acidosis, temperature and exercise using various models (murine, fish, insects, human derived cell lines).
Teaching | Current
BIOSCI758 - Development, differenciation and disease: Mitochondrial (dys)function
BIOSCI725 - Ecological Physiology: Seminar on Hypoxia
Areas of expertise
Mitochondrial physiology, respirometry, fluorimetry, spectrophotometry.
Real-time high resolution respirometry coupled with fluorimetry to assess (in part) oxygen consumption, reactive oxygen species generation, ATP production, membrane potential regulation, redox balance, substrate utilisation, calcium handling and pH buffering.
Selected publications and creative works (Research Outputs)
- Farhat, F., Simon, B., Amerand, A., Devaux, J., Belhomme, M., Calves, P., & Moisan, C. (2020). Exercise training changes mitochondrial function and its vulnerability to reactive oxygen species exposure differently in male and female silver European eels. ENVIRONMENTAL BIOLOGY OF FISHES, 103 (4), 363-375. 10.1007/s10641-020-00962-z
- Hunter, F. W., Devaux, J. B. L., Meng, F., Hong, C. R., Khan, A., Tsai, P., ... Marastoni, S. (2019). Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide. Molecular pharmacology, 95 (6), 638-651. 10.1124/mol.118.115196
Other University of Auckland co-authors: Francis Hunter, Stefan Bohlander, Peter Tsai, Purvi Kakadiya, Tony Hickey, Cristin Print
- Horscroft, J. A., O'Brien KA, Clark, A. D., Lindsay, R. T., Steel, A. S., Procter, N. E. K., ... Murray, A. J. (2019). Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (6), 7563-7577. 10.1096/fj.201900067R
- Hedges, C. P., Wilkinson, R. T., Devaux, J. B. L., & Hickey, A. J. R. (2019). Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 230, 115-121. 10.1016/j.cbpa.2019.01.002
Other University of Auckland co-authors: Chris Hedges, Tony Hickey
- O'Brien KA, Horscroft, J. A., Devaux, J., Lindsay, R. T., Steel, A. S., Clark, A. D., ... Murray, A. J. (2019). PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia. Biochimica et biophysica acta. Molecular basis of disease, 1865 (4), 844-853. 10.1016/j.bbadis.2018.07.027
- Devaux, J. B. L., Hickey, A. J. R., & Renshaw, G. M. C. (2019). Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/re-oxygenation. The Journal of experimental biology, 222 (Pt 6).10.1242/jeb.191353
Other University of Auckland co-authors: Tony Hickey
- Devaux, J. B. (2019). Mitochondrial adaptations involved in hypoxia and anoxia-tolerance of intertidal fish The University of Auckland. ResearchSpace@Auckland.
- Devaux, J. B. L., Hedges, C. P., Birch, N., Herbert, N., Renshaw, G. M. C., & Hickey, A. J. R. (2018). Acidosis Maintains the Function of Brain Mitochondria in Hypoxia-Tolerant Triplefin Fish: A Strategy to Survive Acute Hypoxic Exposure?. Frontiers in physiology, 910.3389/fphys.2018.01941
Other University of Auckland co-authors: Tony Hickey, Chris Hedges, Neill Herbert