Dr Jack Urquhart Flanagan

Biography

Jack Flanagan obtained his BSc(Hons) in Biochemistry and Molecular Genetics at Victoria University of Wellington, New Zealand, and was awarded a PhD scholarship to study at the John Curtin School of Medical Research, Australian National University, Australia where he investigated structure function relationships for the glutathione transferase class of detoxication enzyme in the laboratory of Prof Philip Board. After a postdoctoral position researching structure function relationships in the major drug metabolising cytochromes P450 under Prof Roland Wolf at the Biomedical Research Centre, University of Dundee, United Kingdom, he took up a Howard Florey Centenary Fellowship at the Institute for Molecular Biosciences, University of Queensland, Australia looking at inhibitor discovery for the human hematopoietic prostaglandin D2 synthase enzyme. Currently a Senior Research Fellow at the Auckland Cancer Society Research Centre, Jack is involved in integrating molecular modelling and virtual screening methods of inhibitor discovery into a number of current medicinal chemistry projects. He is also an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery.

Research interests:

Research groups:

Research | Current

  • Discovery and development of compounds inhibiting the synthesis of secondary lipid signalling molecules including prostanoids synthesised through the cyclooxygenase pathway, and phosphatidylinositides synthesised by the phosphoinositide 3 kinase family of enzymes.
  • Exploration of ligand specificity and inhibitor discovery for hemo-proteins involved in cancer.
  • Characterising the molecular basis of ligand recognition by interrogating biological data using analytical Quantitative Structure Activity Relationship techniques that incorporate physico-chemical properties of ligands.
  • Molecular docking and virtual screening as methods to identify candidate inhibitors for proteins of interest.
  • Fold prediction and comparative modelling of proteins and protein families as a method for hypothesis development about activity differences between isoforms.

Selected publications and creative works (Research Outputs)

Contact details

Primary location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 119
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand