Dr June-Chiew Han
June-Chiew Han received a Bachelor of Engineering (Honours) in Biomedical Engineering and a PhD in Bioengineering from the University of Auckland.
His PhD thesis involved simultaneous measurement of the heat and force production of rat cardiac trabeculae (a muscle of radial dimensions about the size of a human hair and about 3 mm long) to investigate their mechanoenergetics properties using the ABI-developed micromechanocalorimeter. An article resulting from this work appeared in the Journal of Applied Physiology.
Research | Current
June-Chiew's current post-doc research focuses on the effects of hypertension, hypertrophy, diabetes, and diet on cardiac energetics; specifically, how they affect myocardial mechanical efficiency. Energetic experiments are performed at the whole-heart level and at the trabecula level. Experiments are also performed at the sub-cellular level.
Selected publications and creative works (Research Outputs)
- Dowrick, J. M., Tran, K., Loiselle, D. S., Nielsen, P. M. F., Taberner, A. J., Han, J.-C., & Ward, M.-L. (2019). The slow force response to stretch: Controversy and contradictions. Acta physiologica (Oxford, England), 226 (1)10.1111/apha.13250
Other University of Auckland co-authors: Kenneth Tran, Denis Loiselle, Poul Nielsen, Marie-Louise Ward, Andrew Taberner
- Han, J.-C., Pham, T., Taberner, A. J., Loiselle, D. S., & Tran, K. (2019). Solving a century-old conundrum underlying cardiac force-length relations. American journal of physiology. Heart and circulatory physiology, 316 (4), H781-H793. 10.1152/ajpheart.00763.2018
Other University of Auckland co-authors: Toan Pham, Andrew Taberner, Denis Loiselle, Kenneth Tran
- Taberner, A. J., Zgierski-Johnston, C. M., Pham, T., Han, J.-C., Uddin, R., Loiselle, D. S., ... Nielsen, P. M. F. (2018). A Flowthrough Infusion Calorimeter for Measuring Muscle Energetics: Design and Performance. IEEE Transactions on Instrumentation and Measurement, 67 (7), 1690-1699. 10.1109/TIM.2018.2800838
Other University of Auckland co-authors: Denis Loiselle, Andrew Taberner, Bryan Ruddy, Poul Nielsen, Toan Pham
- Pham, T., Nisbet, L., Taberner, A., Loiselle, D., & Han, J.-C. (2018). Pulmonary arterial hypertension reduces energy efficiency of right, but not left, rat ventricular trabeculae. The Journal of physiology, 596 (7), 1153-1166. 10.1113/jp275578
Other University of Auckland co-authors: Toan Pham, Andrew Taberner, Denis Loiselle
- Pham, T., Han, J.-C., Taberner, A., & Loiselle, D. (2017). Do right-ventricular trabeculae gain energetic advantage from having a greater velocity of shortening?. The Journal of Physiology, 595 (20), 6477-6488. 10.1113/JP274837
Other University of Auckland co-authors: Toan Pham, Denis Loiselle, Andrew Taberner
- Tran, K., Han, J.-C., Crampin, E. J., Taberner, A. J., & Loiselle, D. S. (2017). Experimental and modelling evidence of shortening heat in cardiac muscle. Journal of Physiology, 595 (19), 6313-6326. 10.1113/JP274680
Other University of Auckland co-authors: Denis Loiselle, Kenneth Tran, Andrew Taberner
- Pham, T., Tran, K., Mellor, K. M., Hickey, A., Power, A., Ward, M. L., ... Loiselle, D. (2017). Does the intercept of the heat-stress relation provide an accurate estimate of cardiac activation heat?. The Journal of Physiology, 595 (14), 4725-4733. 10.1113/jp274174
Other University of Auckland co-authors: Kenneth Tran, Kim Mellor, Andrew Taberner, Denis Loiselle, Marie-Louise Ward, Toan Pham, Tony Hickey
- Garrett, A. S., Pham, T., Loiselle, D. S., June-Chiew Han, & Taberner, A. J. (2017). Real-time model-based control of afterload for in vitro cardiac tissue experimentation.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 10.1109/embc.2017.8037067
Other University of Auckland co-authors: Andrew Taberner, Denis Loiselle, Toan Pham