Dr June-Chiew Han
June-Chiew Han received a Bachelor of Engineering (Honours) in Biomedical Engineering and a PhD in Bioengineering from the University of Auckland.
His PhD thesis involved simultaneous measurement of the heat and force production of rat cardiac trabeculae (a muscle of radial dimensions about the size of a human hair and about 3 mm long) to investigate their mechanoenergetics properties using the ABI-developed micromechanocalorimeter. An article resulting from this work appeared in the Journal of Applied Physiology.
Research | Current
June-Chiew's current post-doc research focuses on the effects of hypertension, hypertrophy, diabetes, and diet on cardiac energetics; specifically, how they affect myocardial mechanical efficiency. Energetic experiments are performed at the whole-heart level and at the trabecula level. Experiments are also performed at the sub-cellular level.
Selected publications and creative works (Research Outputs)
- Choi, D. H., Pham, T., Loiselle, D. S., Taberner, A. J., Han, J.-C., & Tran, K. (2020). The Inverse Relationship between Cardiac Muscle Stress and Cross-Sectional Area Is Preserved in Ba(2+)Contracture and in Chemically-Permeabilised Ca(2+)Contracture. EXPERIMENTAL MECHANICS10.1007/s11340-020-00652-y
Other University of Auckland co-authors: Toan Pham, Denis Loiselle, Andrew Taberner, Kenneth Tran
- Mellor, N. G., Pham, T., Tran, K., Loiselle, D. S., Ward, M.-L., Taberner, A. J., ... Han, J.-C. (2020). Disruption of transverse-tubular network reduces energy efficiency in cardiac muscle contraction. Acta physiologica (Oxford, England)10.1111/apha.13545
Other University of Auckland co-authors: Toan Pham, Kenneth Tran, Denis Loiselle, Marie-Louise Ward, Andrew Taberner, David Crossman
- Cheuk, M. L., Lam Po Tang, E. J., HajiRassouliha, A., Han, J.-C., Nielsen, P. M. F., & Taberner, A. J. (2020). A Method for Markerless Tracking of the Strain Distribution of Actively Contracting Cardiac Muscle Preparations. EXPERIMENTAL MECHANICS10.1007/s11340-020-00646-w
Other University of Auckland co-authors: Poul Nielsen, Andrew Taberner
- Tran, K., Taberner, A. J., Loiselle, D. S., & Han, J.-C. (2020). Energetics Equivalent of the Cardiac Force-Length End-Systolic Zone: Implications forContractility and Economy of Contraction. FRONTIERS IN PHYSIOLOGY, 1010.3389/fphys.2019.01633
Other University of Auckland co-authors: Denis Loiselle, Kenneth Tran, Andrew Taberner
- Garrett, A. S., Pham, T., Loiselle, D., Han, J.-C., & Taberner, A. (2019). Mechanical loading of isolated cardiac muscle with a real-time computed Windkessel model of the vasculature impedance. Physiological reports, 7 (17)10.14814/phy2.14184
Other University of Auckland co-authors: Andrew Taberner, Denis Loiselle, Toan Pham
- Pham, T., Zgierski-Johnston, C. M., Tran, K., Taberner, A. J., Loiselle, D. S., & Han, J.-C. (2019). Energy expenditure for isometric contractions of right and left ventricular trabeculae over a wide range of frequencies at body temperature. Scientific reports, 9 (1)10.1038/s41598-019-45273-1
Other University of Auckland co-authors: Toan Pham, Kenneth Tran, Denis Loiselle, Andrew Taberner
- Tomalka, A., Röhrle O, Han, J.-C., Pham, T., Taberner, A. J., & Siebert, T. (2019). Extensive eccentric contractions in intact cardiac trabeculae: revealing compelling differences in contractile behaviour compared to skeletal muscles. Proceedings. Biological sciences, 286 (1903)10.1098/rspb.2019.0719
Other University of Auckland co-authors: Toan Pham, Andrew Taberner
- Dowrick, J. M., Tran, K., Loiselle, D. S., Nielsen, P. M. F., Taberner, A. J., Han, J.-C., & Ward, M.-L. (2019). The slow force response to stretch: Controversy and contradictions. Acta physiologica (Oxford, England), 226 (1)10.1111/apha.13250
Other University of Auckland co-authors: Kenneth Tran, Denis Loiselle, Poul Nielsen, Marie-Louise Ward, Andrew Taberner, Jarrah Dowrick