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Dr Jagdish Kumar Jaiswal

BPharm, MPharm, PhD

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Research Fellow
In: Auckland Cancer Society Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

  • B. Pharm - Institute of Technology, Banaras Hindu University (India)
  • M. Pharm (Pharmaceutics) - Jadavpur University (India)
  • PhD (Pharmacology) - All India Institute of Medical Sciences (India)
  • Visiting DAAD Fellow in the laboratories of Prof. Jorg Kreuter at Frankfurt Biocentre, Johann Wolfgang Goethe University, Germany
  • Research Associate (Drug Discovery- Pharmacology)-  Torrent Research Centre, India
  • Post doctoral research fellow - Auckland Cancer Society Research Centre (2005-2007)

Research interests

Current Projects

Small molecules perforin inhibitor (Wellcome Trust, UK)

Past projects

  • Clinical Phase I candidate PR-610. Pre-clinical pharmacokinetic studies (PIs- Drs Adam Patterson and Jeff Smaiil)
  • Clinical Phase II/III candidate PR-104. Formulation stability and rat toxicity study (Principal Investigator - Prof. Bill Wilson)
  • Clinical development candidate CEN-209 (SN30000). preclinical ADME studies (Principal Investigator - Prof. Bill Wilson)
  • NitroCBI analogs. Preclinical  ADME studies (Principal Investigators Drs. Frederik Pruijn and Moana Tercel)

Research | Current

  • ADME/Tox of anti cancer drugs in pre-clinical development
  • LC-MS/MS method development

Postgraduate supervision

Small animal pharmacokinetic studies

Bioanalysis

Responsibilities

Pre clinical DMPK studies (small animals)

Bio-analysis (LC-MS/MS, LC-MS, Ion trap, HPLC)
 

Areas of expertise

Preclinical drug development of small molecules

Measurement of drug, metabolites in biological matrix (serum, plasma, saliva etc) by LC-MS/MS, HPLC.

Selected publications and creative works (Research Outputs)

  • Spicer, J. A., Miller, C. K., O'Connor PD, Jose, J., Huttunen, K. M., Jaiswal, J. K., ... Trapani, J. A. (2017). Substituted arylsulphonamides as inhibitors of perforin-mediated lysis. European Journal of Medicinal Chemistry, 137, 139-155. 10.1016/j.ejmech.2017.05.048
    Other University of Auckland co-authors: Christian Miller, Julie Spicer, Jiney Jose, Bill Denny
  • Gu, Y., Chang, T. T.-A., Wang, J., Jaiswal, J. K., Edwards, D., Downes, N. J., ... Hickey, A. J. (2017). Reductive metabolism influences the toxicity and pharmacokinetics of the hypoxia-targeted benzotriazine di-oxide anticancer agent SN30000 in mice. Frontiers in Pharmacology, 8, 1-16. 10.3389/fphar.2017.00531
    Other University of Auckland co-authors: Tony Hickey, Yongchuan Gu, Frederik Pruijn, Michael Hay, William Wilson, Kevin Hicks, Courtney Lynch
  • Bisht, R., Jaiswal, J., Oliver, V., Eurtivong, C., Reynisson, J., & Rupenthal, I. D. (2017). Preparation and evaluation of PLGA nanoparticle-loaded biodegradable light-responsive injectable implants as a promising platform for intravitreal drug delivery. Journal of Drug Delivery Science and Technology, 40, 142-156. 10.1016/j.jddst.2017.06.006
    Other University of Auckland co-authors: Verity Oliver, Johannes Reynisson, Ilva Rupenthal
  • Bisht, R., Rupenthal, I. D., Sreebhavan, S., & Jaiswal, J. K. (2017). Development of a novel stability indicating RP-HPLC method for quantification of Connexin43 mimetic peptide and determination of its degradation kinetics in biological fluids. Journal of Pharmaceutical Analysis, 7 (6), 365-373. 10.1016/j.jpha.2017.06.008
    Other University of Auckland co-authors: Ilva Rupenthal, Sree Sreebhavan
  • Bisht, R., Jaiswal, J. K., & Rupenthal, I. D. (2017). Nanoparticle-loaded biodegradable light-responsive in situ forming injectable implants for effective peptide delivery to the posterior segment of the eye. Medical Hypotheses, 103, 5-9. 10.1016/j.mehy.2017.03.033
    Other University of Auckland co-authors: Ilva Rupenthal
  • Bisht, R., Mandal, A., JAISWAL, J. K., & RUPENTHAL, I. (2017). Nanotechnology Enhances Drug Delivery to the Back of the Eye. USA: Advance Science News. Related URL.
    Other University of Auckland co-authors: Ilva Rupenthal
  • Bisht, R., Mandal, A., Jaiswal, J. K., & Rupenthal, I. D. (2017). Nanocarrier mediated retinal drug delivery: Overcoming ocular barriers to treat posterior eye diseases. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 10 (2)10.1002/wnan.1473
    Other University of Auckland co-authors: Ilva Rupenthal
  • Spicer, J. A., Miller, C. K., O'Connor PD, Jose, J., Huttunen, K. M., Jaiswal, J. K., ... Trapani, J. A. (2017). Benzenesulphonamide inhibitors of the cytolytic protein perforin. Bioorganic and Medicinal Chemistry Letters, 27 (4), 1050-1054. 10.1016/j.bmcl.2016.12.057
    URL: http://hdl.handle.net/2292/33158
    Other University of Auckland co-authors: Bill Denny, Julie Spicer, Christian Miller, Jiney Jose

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