Dr Jiney Jose

Biography

Jiney Jose obtained his MS and PhD degrees in Organic Chemistry from Texas A&M Univeristy, Texas working with Prof. Kevin Burgess. His research involved development of organic fluorescent probes and nanoparticles for cellular imaging studies. He received a cancer prevention research institute of Texas (CPRIT) fellowship to pursue postdoctoral research with Prof. Eric V. Anslyn/ Prof. Kevin Dalby at the University of Texas at Austin. His research focused on developing tryptamine analogues for the treatment of breast cancer. He joined the Centre in 2012 as a research fellow. He is an Affiliate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery at the University of Auckland.

Research Interests

Cancer research, medicinal chemistry, synthetic organic chemistry, fluorescent probes and nanoparticles,  immunosuppressive therapy, short acting anaesthetics.

Research | Current

https://www.fmhs.auckland.ac.nz/en/sms/about/our-departments/auckland-cancer-society-research-centre/research-groups/medicinal-chemistry/inhibition-of-perforin.html

Selected publications and creative works (Research Outputs)

  • Jose, J., Tavares, C. D. J., Ebelt, N. D., Lodi, A., Edupuganti, R., Xie, X., ... Anslyn, E. V. (2017). Serotonin analogues as inhibitors of breast cancer cell growth. ACS Medicinal Chemistry Letters10.1021/acsmedchemlett.7b00282
  • Harvey, M., Sleigh, J., Voss, L., Jose, J., Gamage, S., Pruijn, F., ... Denny, W. (2015). Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs. Anesthesia and analgesia, 121 (4), 925-933. 10.1213/ane.0000000000000719
    URL: http://hdl.handle.net/2292/26105
    Other University of Auckland co-authors: Swarna Gamage, Frederik Pruijn, Bill Denny, Jamie Sleigh
  • Harvey, M., Sleigh, J., Voss, L., Pruijn, F., Jose, J., Gamage, S., & Denny, W. (2015). Determination of the Hypnotic Potency in Rats of the Novel Ketamine Ester Analogue SN 35210. Pharmacology, 96 (5-6), 226-232. 10.1159/000439598
    Other University of Auckland co-authors: Frederik Pruijn, Jamie Sleigh, Bill Denny
  • Zamora-Olivares, D., Kaoud, T. S., Jose, J., Ellington, A., Dalby, K. N., & Anslyn, E. V. (2014). Differential sensing of MAP kinases using SOX-peptides. Angewandte Chemie (International ed. in English), 53 (51), 14064-14068. 10.1002/anie.201408256
  • Devkota, A. K., Edupuganti, R., Yan, C., Shi, Y., Jose, J., Wang, Q., ... Dalby, K. N. (2014). Reversible Covalent Inhibition of eEF-2K by Carbonitriles. ChemBioChem, 15 (16), 2435-2442. 10.1002/cbic.201402321
  • Jose, J. (2014). Structure-activity relationships for ketamine esters as short-acting anaesthetics. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248
    Other University of Auckland co-authors: Bill Denny, Swarna Gamage, Jamie Sleigh
  • Jose, J., Gamage, S. A., Harvey, M. G., Voss, L. J., Sleigh, J. W., & Denny, W. A. (2013). Structure-activity relationships for ketamine esters as short-acting anaesthetics. Bioorg Med Chem, 21 (17), 5098-5106. 10.1016/j.bmc.2013.06.047
    URL: http://hdl.handle.net/2292/32034
    Other University of Auckland co-authors: Bill Denny, Swarna Gamage, Jamie Sleigh
  • Kaoud, T. S., Yan, C., Mitra, S., Tseng, C.-C., Jose, J., Taliaferro, J. M., ... Park, J. (2012). From in Silico Discovery to Intracellular Activity: Targeting JNK-Protein Interactions with Small Molecules. ACS Medicinal Chemistry Letters, 3 (9), 721-725. 10.1021/ml300129b