Dr Jiney Jose

Biography

Jiney Jose obtained his MS and PhD degrees in Organic Chemistry from Texas A&M Univeristy, Texas working with Professor Kevin Burgess. His research involved development of organic fluorescent probes and nanoparticles for cellular imaging studies. He received a cancer prevention research institute of Texas (CPRIT) fellowship to pursue postdoctoral research with Professor Eric V. Anslyn/ Prof. Kevin Dalby at the University of Texas at Austin. His research focused on developing tryptamine analogues for the treatment of breast cancer. He joined the Centre in 2012 as a research fellow. He is an Affiliate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery at the University of Auckland.

 

Research | Current

  • His research interest includes cancer research, medicinal chemistry, synthetic organic chemistry, fluorescent probes and nanoparticles,  immunosuppressive therapy, short acting anaesthetics.
  • He is currently involved in an immunotherapy project developing small molecules for the treatment of Leukaemia. https://www.fmhs.auckland.ac.nz/en/sms/about/our-departments/auckland-cancer-society-research-centre/research-groups/medicinal-chemistry/inhibition-of-perforin.html
  • He is also involved in the development and application of tumour targeting theranostic drug dye conjugates with brain penetrant properties for treatment of paediatric and adult brain cancers.https://curekids.org.nz/researchers/jiney-jose/
  • He is always interested in training students who has an interest in medicinal chemistry.

Recent publications:

  • Cooper, E., Choi, P.J., Schweder, P., Mee, E., Turner, C., Faull, R., Denny, W.A., Dragunow, M., Park, T. I-H., Jose, J. (2021). Cytoprotective agent troxipide-cyanine dye conjugate with cytotoxic and antiproliferative activity in patient-derived glioblastoma cell lines. Bioorg. Med. Chem. Lett., 50, 128336.
  • Cooper, E., Choi, P.J., Denny, W.A., Jose, J., Dragunow, M., Park, T. I-H. (2021). The use of Heptamethine Cyanine Dyes as Drug-conjugate Systems in the Treatment of Primary and Metastatic Brain Tumors. Front. Oncol., 11, 654921.
  • Choi, P. J., Park, T. I-H., Cooper, E., Dragunow, M., William A. Denny, W. A., Jose, J. (2020). Heptamethine cyanine dye mediated drug delivery: hype or hope. Bioconjug. Chem., 31 (7), 1724-1739.

Teaching | Current

  • 2020-present: CHEM750-Cancer drugs: Design, Chemistry and Mechanism of Action (Module coordinator and Lecturer)
  • 2018: Pharm753 (Lecturer)

Postgraduate supervision

Current students:

  • 2021-: Christine Kim (PhD, co-supervisor)
  • 2021-: Harpinder Brar (PhD, co-supervisor)
  • 2020-: Elizabeth Cooper (PhD, co-supervisor)
  • 2021: Anna Cullen (BSc (Hons), Supervisor)

Past students:

  • 2019: Elizabeth Cooper (BSc (Hons), co-supervisor)
  • 2018: Ben Maloney (Summer studentship, co-supervisor)
  • 2018: Elizabeth Cooper (Summer studentship, co-supervisor)
  • 2018: Tina Shaban (Northern Hemisphere Summer studentship, supervisor) 

Distinctions/Honours

  • 2018: Keith & Meida Hepburn Young Scientist Award’ from the Cancer Society Auckland-Northland
  • 2010-2011: Cancer prevention research institute of Texas post doctoral fellowship
  • 2008: A.E. Martell Foundation Award, Department of Chemistry, Texas A&M University
  • 2003-2009: Texas A&M University postgraduate scholarship
  • 2002: Dyestuff Manufacturers Association of India Award for academic excellence, Mumbai, India

Areas of expertise

Drug development

Medicinal chemistry

Trageted therapy

Organic chemistry

Organic fluorescent dyes

 

Committees/Professional groups/Services

  • 2019- present: Neurological foundation, New Zealand (NF)
  • 2019-present: New Zealand Institute of Chemistry (NZIC)
  • 2017-present: Independent chair for University of Auckland doctoral oral examinations.
  • 2016-present: Reviewer for Journals: Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Molecules, High Throughput, Marine drugs, Talanta
  • 2008-present: Phi Kappa Phi Honour Society, United States of America
  • 2003-present: American Chemical Society (ACS)

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Choi, P. J., Park, T. I. H., Cooper, E., Dragunow, M., Denny, W. A., & Jose, J. (2020). Heptamethine Cyanine Dye Mediated Drug Delivery: Hype or Hope. Bioconjugate chemistry, 31 (7), 1724-1739. 10.1021/acs.bioconjchem.0c00302
    Other University of Auckland co-authors: Bill Denny, Thomas Park, Peter Choi
  • Choi, P. J., Cooper, E., Schweder, P., Mee, E., Turner, C., Faull, R., ... Jose, J. (2020). PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines. Bioorganic & medicinal chemistry letters, 30 (14)10.1016/j.bmcl.2020.127252
    Other University of Auckland co-authors: Peter Choi, Bill Denny, Michael Dragunow, Thomas Park, Richard Faull
  • Choi, P. J., Cooper, E., Schweder, P., Mee, E., Faull, R., Denny, W. A., ... Jose, J. (2019). The synthesis of a novel Crizotinib heptamethine cyanine dye conjugate that potentiates the cytostatic and cytotoxic effects of Crizotinib in patient-derived glioblastoma cell lines. Bioorganic and Medicinal Chemistry Letters, 29 (18), 2617-2621. 10.1016/j.bmcl.2019.07.051
    Other University of Auckland co-authors: Thomas Park, Peter Choi, Richard Faull, Bill Denny, Michael Dragunow
  • Jose, J., Spicer, J., Miller, C. K., O'Connor P, Giddens, A., Akhlaghi, H., ... Denny, W. A. (1/4/2019). Development of inhibitors of the pore forming protein perforin for the treatment of leukaemia. Poster presented at 257th ACS National Meeting & Exposition, Orlando, FL, United States. MEDI-0164. Related URL.
    Other University of Auckland co-authors: Julie Spicer, Anna Giddens, Bill Denny
  • Jose, J., Choi, P., Noguchi, K., Ishiyama, M., & Denny, W. (31/3/2019). Synthesis of near-infrared emitting fluorescent dyes and their application in organelle specific labelling studies. Poster presented at 257th National Meeting of the American-Chemical-Society (ACS), Orlando, FL. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
    Other University of Auckland co-authors: Peter Choi, Bill Denny
  • Dimitrov, I., Denny, W. A., & Jose, J. (2018). Syntheses of Ketamine and Related Analogues: A Mini Review. SYNTHESIS-STUTTGART, 50 (21), 4201-4215. 10.1055/s-0037-1609935
    URL: http://hdl.handle.net/2292/45768
    Other University of Auckland co-authors: Bill Denny, Ivo Dimitrov
  • Choi, P., Noguchi, K., Ishiyama, M., Denny, W. A., & Jose, J. (2018). A mitochondria-selective near-infrared-emitting fluorescent dye forcellular imaging studies. Bioorganic & medicinal chemistry letters, 28 (11), 2013-2017. 10.1016/j.bmcl.2018.05.001
    Other University of Auckland co-authors: Bill Denny, Peter Choi
  • Jose, J., Spicer, J. A., Miller, C. K., O'Connor PD, Marshal, A., Jaiswal, J., ... Law, R. H. P. (15/9/2017). Thiazolecarboxamides as inhibitors of perforin function for potential immunosuppressive therapy. Poster presented at Drug Discovery India 2017, Bengaluru, India.
    Other University of Auckland co-authors: Julie Spicer, Jagdish Jaiswal, Stephen Jamieson, Bill Denny

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 1, Room 104
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links