Dr Julie Ching-Hsia Lim

BSc/MSc(First class honours)/PhD (University of Auckland)

Senior Lecturer

In: Medical Science » Faculty of Medical and Health Sciences

Senior Research Fellow

In: Physiology » Medical Science » Faculty of Medical and Health Sciences

Research | Current

Research interests include antioxidants, membrane transporters and the lens.

Dr Julie Lim is a Research Fellow in the Molecular Vision Lab headed by Professor Paul Donaldson. Her research is focussed on identifying medical strategies to delay the onset of age related nuclear cataracts. More specifically, she is involved in identifying and characterizing transporters involved in the uptake of antioxidants such as glutathione (GSH) and cysteine.

In 2007 she was awarded a FoRST post-doctoral fellowship which enabled her to translate her work on antioxidant transporters in rodent lenses to human lenses. More recently she was awarded a Sir Charles Hercus Health Research fellowship which will allow her to extend these studies to other tissues of the eye.

Teaching | Current

Optom 272

Optom 472

MedSci 739

Postgraduate supervision

Ankita Umapathy (PhD student): Mapping of glutathione metabolism and transport pathways in the aging eye-is the lens a reservoir of glutathione?

Renita Martis (PhD student): The role of the cystine/glutamate exchanger in maintaining redox balance in the eye

Areas of expertise

Antoxidants, oxidative stress and the aging eye

Selected publications and creative works (Research Outputs)

Martis, R. M., Donaldson, P. J., Li, B., Middleditch, M., Kallingappa, P. K., & Lim, J. C. (2019). Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance. Histochemistry and cell biology, 152 (4), 293-310. 10.1007/s00418-019-01805-4
Other University of Auckland co-authors: Prasanna Kallingappa, Paul Donaldson
Lim, J. C. (2019). Interactions between the lens and ocular humors: identification and visualisation of antioxidant metabolite uptake and efflux pathways in the lens. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA. 28 April - 2 May 2019. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
Knight, L. J., Acosta, M. L., Martis, R., Donaldson, P. J., & Lim, J. C. (2019). The aging retina: early metabolic dysfunction in the retina of the xCT knockout mouse. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA. 28 April - 2 May 2019. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
Other University of Auckland co-authors: Paul Donaldson, Monica Acosta
Braakhuis, A. J., Donaldson, C. I., Lim, J. C., & Donaldson, P. J. (2019). Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies. Nutrients, 11 (5).10.3390/nu11051186
Other University of Auckland co-authors: Paul Donaldson, Andrea Braakhuis
Martis, R. M., Donaldson, P. J., & Lim, J. C. (2019). Corneal opacities in mice exposed to repeated contact procedures during ocular examinations. Clinical and Experimental Optometry10.1111/cxo.12934
Other University of Auckland co-authors: Paul Donaldson
Lam, L., Bagg, W., Smith, G., Chiu, W. W., Middleditch, M. J., Lim, J. C.-H., & Kyle, C. V. (2018). Apparent Hyperthyroidism Caused by Biotin-Like Interference from IgM Anti-Streptavidin Antibodies. Thyroid : official journal of the American Thyroid Association, 28 (8), 1063-1067. 10.1089/thy.2017.0673
URL: http://hdl.handle.net/2292/44794
Other University of Auckland co-authors: Warwick Bagg, Martin Middleditch, Cam Kyle
Donaldson, P. J., Perwick, R., Li, I., Demarais, N. J., Lim, J. C., & Grey, A. (2018). Mapping glucose metabolism pathways in the bovine lens using imaging mass spectrometry. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI. 29 April - 3 May 2018. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 3).
Other University of Auckland co-authors: Paul Donaldson, Gus Grey
Thrimawithana, T. R., Rupenthal, I. D., Räsch SS, Lim, J. C., Morton, J. D., & Bunt, C. R. (2018). Drug delivery to the lens for the management of cataracts. Advanced drug delivery reviews, 126, 185-194. 10.1016/j.addr.2018.03.009
Other University of Auckland co-authors: Ilva Rupenthal