Dr Julie Ching-Hsia Lim
BSc/MSc(First class honours)/PhD (University of Auckland)
Research | Current
Research interests include antioxidants, membrane transporters and the lens.
Dr Julie Lim is a Research Fellow in the Molecular Vision Lab headed by Professor Paul Donaldson. Her research is focussed on identifying medical strategies to delay the onset of age related nuclear cataracts. More specifically, she is involved in identifying and characterizing transporters involved in the uptake of antioxidants such as glutathione (GSH) and cysteine.
In 2007 she was awarded a FoRST post-doctoral fellowship which enabled her to translate her work on antioxidant transporters in rodent lenses to human lenses. More recently she was awarded a Sir Charles Hercus Health Research fellowship which will allow her to extend these studies to other tissues of the eye.
Teaching | Current
Ankita Umapathy (PhD student): Mapping of glutathione metabolism and transport pathways in the aging eye-is the lens a reservoir of glutathione?
Renita Martis (PhD student): The role of the cystine/glutamate exchanger in maintaining redox balance in the eye
Areas of expertise
Antoxidants, oxidative stress and the aging eye
Selected publications and creative works (Research Outputs)
- Li, B., Kim, J.-Y., Martis, R. M., Donaldson, P. J., & Lim, J. C. (2020). Characterisation of Glutathione Export from Human Donor Lenses. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 9 (8)10.1167/tvst.9.8.37
Other University of Auckland co-authors: Paul Donaldson
- Lim, J. C., Li, I., Donaldson, P. J., & Poulsen, R. C. (2020). Shedding new light on the role of the lens in regulating circadian rhythms. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), ELECTR NETWORK. 1 May - 7 May 2020. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
Other University of Auckland co-authors: Raewyn Poulsen, Paul Donaldson
- Lim, J. C., Grey, A. C., Zahraei, A., & Donaldson, P. J. (2020). Age-dependent changes in glutathione metabolism pathways in the lens: New insights into therapeutic strategies to prevent cataract formation-A review. Clinical & experimental ophthalmology10.1111/ceo.13801
Other University of Auckland co-authors: Paul Donaldson, Gus Grey
- Martis, R. M., Donaldson, P. J., & Lim, J. C. (2020). Corneal opacities in mice exposed to repeated contact procedures during ocular examinations. Clinical & experimental optometry, 103 (3), 307-311. 10.1111/cxo.12934
Other University of Auckland co-authors: Renita Martis, Paul Donaldson
- Martis, R. M., Knight, L. J., Donaldson, P. J., & Lim, J. C. (2020). Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues. Oxidative medicine and cellular longevity, 202010.1155/2020/4594606
Other University of Auckland co-authors: Paul Donaldson, Renita Martis, Luis Knight
- Shivashankar, G., Lim, J. C., & Acosta, M. L. (2020). Proinflammatory cytokines trigger biochemical and neurochemical changes in mouse retinal explants exposed to hyperglycemic conditions. Molecular vision, 26, 277-290.
Other University of Auckland co-authors: Monica Acosta
- Martis, R. M., Donaldson, P. J., Li, B., Middleditch, M., Kallingappa, P. K., & Lim, J. C. (2019). Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance. Histochemistry and cell biology, 152 (4), 293-310. 10.1007/s00418-019-01805-4
Other University of Auckland co-authors: Prasanna Kallingappa, Renita Martis, Paul Donaldson
- Lim, J. C. (2019). Interactions between the lens and ocular humors: identification and visualisation of antioxidant metabolite uptake and efflux pathways in the lens. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA. 28 April - 2 May 2019. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).