Dr Jonathan Sperry

PhD/BSc(Hons) (Exon.)

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Associate Professor

Biography

  • Feb 2017-present. Associate Professor in Organic and Medicinal Chemistry, University of Auckland. 
  • Feb 2014- 2019. RSNZ Rutherford Discovery Fellow
  • Feb 2012- Feb 2017. Senior Lecturer in Organic and Medicinal Chemistry, University of Auckland. 
  • Nov 2009- Feb 2012. Lecturer in Organic and Medicinal Chemistry, University of Auckland
  • Mar 2006- Nov 2009. Postdoctoral Research Fellow, University of Auckland, New Zealand, (RSNZ Marsden Fund, D.Prof. M. A. Brimble)
  • Oct 2002- Feb 2006. Ph.D Synthetic Organic Chemistry, University of Exeter, UK. Biomimetic Oxidations in Natural Product Synthesis (Prof. C. J. Moody)
  • 1999-2002. BSc (Hons) Biological and Medicinal Chemistry, 1st class. University of Exeter, UK. Final year project: A Diels Alder approach to Vitamin B6 analogues

Research | Current

****MSc and Ph.D SCHOLARSHIPS AVAILABLE FOR 2017/2018**** Contact Jon if you are interested

BSc(Hons) / MSc

Several Honours and MSc projects are available for students starting in semesters 1 and 2. Please contact Jon for further information

Ph.D studies

A number of funding sources are available to support students into their PhD studies. The application processes are conducted through the University of Auckland, however please get in contact with Jon first to discuss the application. If you are an Australian or New Zealand student with a first class honours degree then you should be eligible for a scholarship.

If you are from outside Australasia, possess a stellar academic record and good English skills (TOEFL scores), I will endeavour to organise a scholarship for you.

If your country has a scholarship program then please contact Jon to see if we are able to support an application.

Our Research interests can be split into three main areas:

- Organic Synthesis -

C-H functionalization

Study of natural product synthesis as a platform for methods development.

Particular emphasis is placed on compounds that possess unprecedented architecture, biomimetic synthesis and novel reaction development.

- Medicinal chemistry -

Design and synthesis of novel biologically active entities based on leads from Nature.

The synthesis and biophysical analysis of isocitrate lyase (ICL) inhibitors for the treatment of latent tuberculosis - in collaboration with Dr Ivan Leung (University of Auckland)

Synthesis of compounds to target superbugs (MRSA, vancomycin resistance, etc.) - in collaboration with the University of British Columbia, Canada

Novel therapeutics targeting the PSA-NCAM complex - in collaboration with A/P Maurice Curtis (Centre for Brain Research)

- Sustainable Synthesis / Green Chemistry -

Platform chemicals in heterocycle and natural products synthesis in collaboration with A/P Shinji Kudo (Kyushu University, Japan) and A/P Ning Yan (National University of Singapore)

Electrochemical and mechanochemical synthesis

Valorization of lignin

Green solvents and reagents.

 

 

Teaching | Current

  • CHEM 230
  • CHEM 260
  • CHEM 330
  • CHEM 360
  • CHEM 730
  • CHEM 735
  • CHEM 750

Postgraduate supervision

Postdoctoral 

Dr Ashley Lindsay

Ph.D

Andrew Eastabrook (2014)

Ram Bhusal (2014)

Joshua Homer (2014)

Emma Davison (2015)

Se Hun Kim (2016)

Ryan Dixon (2016)

Ardalan Nabi (2016)

Magdalena Kohut (2016)

Trang Pham (2016)

Kirsty Anderson (2017)

Jessica Liyu (2017)

Maurycy Prystupa (2017)

Shi-Wei Kim (2017)

BSc (Hons)

Rory Devlin

Vicky Juan

Interns/visiting students

Hanbi You

Alex Sadiq

Linda Nijssen

Wijitra Waengdongbung

 

Distinctions/Honours

RSNZ Rutherford Discovery Fellowship 2014-2019

Thieme Chemistry Journal Award 2014

Deans Commendation 2002

Henry Normon Rydon Award 2001

Deans Commendation 2000

Responsibilities

Associate Professor in Organic and Medicinal Chemistry

Rutherford Discovery Fellow

 

Areas of expertise

Organic and Sustainable Synthesis

Medicinal Chemistry

Heterocyclic Chemistry

Natural Products

Green Chemistry

Committees/Professional groups/Services

Chair: Auckland branch of the New Zealand Institute of Chemistry (NZIC)

Founding member of the Centre for Green Chemical Science (CGCS)

Selected publications and creative works (Research Outputs)

  • Nabi, A. A., Liyu, J., Lindsay, A. C., & Sperry, J. (2017). C4−H alkoxylation of 6-bromoindole and its application to the synthesis of breitfussin B. Tetrahedron10.1016/j.tet.2017.10.067
  • Homer, J. A., & Sperry, J. (2017). Mushroom-Derived Indole Alkaloids. Journal of natural products, 80 (7), 2178-2187. 10.1021/acs.jnatprod.7b00390
  • Bhusal, R. P., Bashiri, G., Kwai, B. X. C., Sperry, J., & Leung, I. K. H. (2017). Targeting isocitrate lyase for the treatment of latent tuberculosis. Drug Discovery Today, 22 (7), 1008-1016. 10.1016/j.drudis.2017.04.012
    Other University of Auckland co-authors: Ivanhoe Leung, Ghader Bashiri, Ram Bhusal
  • Lindsay, A. C., & Sperry, J. (2017). Observations arising from a Beckmann rearrangement-Mannich cyclization approach to the azepinobisindole alkaloid iheyamine A. Tetrahedron, 73 (30), 4355-4362. 10.1016/j.tet.2017.05.093
    Other University of Auckland co-authors: Ashley Lindsay
  • Badrinarayanan, S., Squire, C. J., Sperry, J., & Brimble, M. A. (2017). Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B. Organic letters, 19 (13), 3414-3417. 10.1021/acs.orglett.7b01371
    Other University of Auckland co-authors: Christopher Squire, Margaret Brimble
  • Liyu, J., & Sperry, J. (2017). Synthesis of putative clausenal from carbazole using sequential C–H borylations. Tetrahedron Letters, 58 (17), 1699-1701. 10.1016/j.tetlet.2017.03.051
  • Kudo, S., Goto, N., Sperry, J., Norinaga, K., & Hayashi, J.-I. (2017). Production of Levoglucosenone and Dihydrolevoglucosenone by Catalytic Reforming of Volatiles from Cellulose Pyrolysis Using Supported Ionic Liquid Phase. ACS Sustainable Chemistry and Engineering, 5 (1), 1132-1140. 10.1021/acssuschemeng.6b02463
  • Naysmith, B. J., Hume, P. A., Sperry, J., & Brimble, M. A. (2017). Pyranonaphthoquinones – isolation, biology and synthesis: an update. Nat. Prod. Rep10.1039/C6NP00080K
    URL: http://hdl.handle.net/2292/32128
    Other University of Auckland co-authors: Paul Hume, Margaret Brimble

Contact details

Primary location

SCIENCE CENTRE - CHEMISTRY - Bldg 301
Level 7, Room 727A
23 SYMONDS ST
AUCKLAND 1010
New Zealand