Dr Kenneth Tran
Kenneth's doctoral work focussed on developing a mathematical model of the cardiac ventricular myocyte that couples together energy demand and supply processes within the cell. This provides a tool to investigate and delineate the pathways that lead to pathologies arising from a mismatch in energy balance, such as ischaemia where a portion of the heart tissue becomes poorly perfused due to a blockage of the coronary vessels.
Subsequent to his graduation, Kenneth was appointed as a postdoctoral research fellow at the ABI.
Research | Current
Kenneth is currently working as a postdoctoral fellow on the Virtual Physiological Rat (VPR) which is an international collaboration focussed on developing models to understand and investigate the rat physiome. Kenneth is focussed on further developing his cell model and supplementing it with experimental data from rat cardiac tissue to progress the ABI's understanding of cardiac energetics.
- Lauren Dupuis (Masters, 2014)
- Megan Guidry (Masters, 2016)
Areas of expertise
Computational modelling of cardiac cellular bioenergetics.
Selected publications and creative works (Research Outputs)
- Han, J.-C., Pham, T., Taberner, A. J., Loiselle, D. S., & Tran, K. (2019). Solving a century-old conundrum underlying cardiac force-length relations. American journal of physiology. Heart and circulatory physiology, 316 (4), H781-H793. 10.1152/ajpheart.00763.2018
Other University of Auckland co-authors: June-Chiew Han, Toan Pham, Andrew Taberner, Denis Loiselle
- Dowrick, J. M., Tran, K., Loiselle, D. S., Nielsen, P. M. F., Taberner, A. J., Han, J.-C., & Ward, M.-L. (2019). The slow force response to stretch: Controversy and contradictions. Acta physiologica (Oxford, England)10.1111/apha.13250
Other University of Auckland co-authors: June-Chiew Han, Denis Loiselle, Poul Nielsen, Marie-Louise Ward, Andrew Taberner
- Ghosh, S., Tran, K., Delbridge, L. M. D., Hickey, A. J. R., Hanssen, E., Crampin, E. J., & Rajagopal, V. (2018). Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture. PLoS computational biology, 14 (12)10.1371/journal.pcbi.1006640
Other University of Auckland co-authors: Vijayaraghavan Rajagopal, Tony Hickey
- Pan, M., Gawthrop, P. J., Tran, K., Cursons, J., & Crampin, E. J. (2018). Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states. Proceedings. Mathematical, Physical, and Engineering Sciences, 474 (2214)10.1098/rspa.2018.0106
- GHOSH, S. H. O. U. R. Y. A. D. I. P. T. A., Tran, K., Delbridge, L., Hickey, A., Hanssen, E., Crampin, E., & Rajagopal, V. (2018). Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture. 10.1101/327254
Other University of Auckland co-authors: Vijayaraghavan Rajagopal
- Schroeder, A., Babarenda Gamage, T. P., Wang, V., Loiselle, D. S., Nielsen, P. M. F., Nickerson, D. P., ... Tran, K. (2018). Computational Modelling of Cardiac Trabecula Mechanics. ANZIAM Journal Proceedings Engineering Mathematics and Applications Conference, 59 (esuppl.), C29-C48. Auckland, New Zealand: Australian Mathematical Society. 10.21914/anziamj.v59i0.12682
Other University of Auckland co-authors: Thiranja Babarenda Gamage, Denis Loiselle, Poul Nielsen, David Nickerson, Andrew Taberner, Martyn Nash
- Ghosh, S., Tran, K., Crampin, E., Hanssen, E., & Rajagopal, V. (1/2/2018). Creatine-Kinase Shuttle and Rapid Mitochondrial Membrane Potential Conductivity are Needed Simultaneously to Maintain Uniform Metabolite Distributions in the Cardiac Cell Contraction Cycle. Biophysical Journal. 10.1016/j.bpj.2017.11.3004
- Pan, M., Gawthrop, P. J., Tran, K., Cursons, J., & Crampin, E. J. (2018). A thermodynamic framework for modelling membrane transporters. Journal of Theoretical Biology10.1016/j.jtbi.2018.09.034