Professor Larry William Chamley

BSc (Waikato), MSc(Hons) (Auckland), PhD

Biography

Larry Chamley is Professor of Reproductive Biology and Reproductive Immunology in the Department of Obstetrics and Gynaecology, and is the Director of the Hub for Extracellular Investigations (HEVI) at the University of Auckland, New Zealand. He completed his PhD in the Department of Obstetrics and Gynaecology (Auckland) studying the role of antiphospholipid antibodies in causing stillbirths and recurrent miscarriages. He was then awarded a Health Research Council (NZ) Overseas Fellowship and moved to the Department of Immunology, University of Liverpool (UK), where he investigated the involvement of complement regulatory proteins in early pregnancy failure. In 1996 Larry returned to Auckland to the Department of Obstetrics and Gynaecology to establish his own laboratory studying the role of the placenta in both healthy and diseased pregnancies.

Larry’s research group now study the role of placental extracellular vesicles in controlling the maternal physiological adaptations to pregnancy, as well as the anti-inflammatory activities of extracellular vesicles from mesenchymal stem cells. He is an Associate Editor of the Journal 'Reproduction' and a member of the editorial boards of the journals, 'Trophoblast Research', 'Placenta', 'Journal of Reproductive Immunology' and 'American Journal of Reproductive Immunology'. He is a member of the Council of the International Society for the Immunology of Reproduction and the Chair of the Publications Committee of the American Society for Reproductive Immunology.

Research | Current

Major research interests are

  • Extracellular vesicles
  • Role of placental extracellular vesicles in regulating the maternal immue system in pregnancy
  • Role of placental extracellular vesicles in regulating the maternal cardiovascular system in pregnancy
  • Preeclampsia and recurrent miscarriage
  • The causes of autoimmune reproductive failure, in particular the effects of antiphospholipid antibodies 
  • The use of mesenchymal stem cells and thier extracellular vesicles in regenerative medicine
  • The biological function of SPRASA, a sperm protein discovered by the research team

Teaching | Current

Module Director, MBChB 321 Reproduction Development and Aging

MEDSCI 142 Organ Systems

MEDSCI 201 Human Structure and Function

MEDSCI 313 Reproductive Biology

MEDSCI 314 Immunology

MEDSCI 730 Reproductive Science

Postgraduate supervision

Mathew Kang (PhD Candidate)

Yohanes Nursalum  (PhD Candidate)

Yourong Feng (PhD Candidate)

Tainjiao Geng (PhD Candidate)

Cherry Sun  (PhD Candidate)

Anna Boss  (PhD Candidate)

Anandita Umapthy (PhD Candidate)

 

Distinctions/Honours

Fellow of the Society for Reproductive Biology (FSRB)

Responsibilities

Director of the Hub For Extracellular Vesicle Investigations (HEVI)

Areas of expertise

Extracellular Vesicles

Human Placenta

Reproductive Biology

Reproductive Immunology

 

Committees/Professional groups/Services

Associate Editor of the Journal 'Reproduction'

Members of the Editoral Boards of the Journals; 'Placenta', 'Trophoblast Research', 'Journal of Reproductive Immunology', 'American Journal of Reproductive Immunology'

Chair, Publications Committee, American Society of Reproductive Immunology

Council Member, International Society of the Immunology of Reproduction.

Selected publications and creative works (Research Outputs)

  • Mulla, M. J., Pasternak, M. C., Salmon, J. E., Chamley, L. W., & Abrahams, V. M. (2019). Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation. Journal of Autoimmunity, 98, 103-112. 10.1016/j.jaut.2018.12.003
  • Tong, M., Abrahams, V. M., & Chamley, L. W. (2018). Immunological effects of placental extracellular vesicles. Immunology and cell biology10.1111/imcb.12049
  • Théry C, Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., ... Atkin-Smith, G. K. (2018). Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of extracellular vesicles, 7 (1)10.1080/20013078.2018.1535750
    Other University of Auckland co-authors: Cherie Blenkiron, Simon Swift
  • Tong, M., Johansson, C., Xiao, F., Stone, P. R., James, J. L., Chen, Q., ... Chamley, L. W. (29/11/2017). Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia.. Scientific reports. 10.1038/s41598-017-16448-5
    Other University of Auckland co-authors: Jo James, Qi Chen, Michelle Wise, Lynsey Cree
  • Tong, M., Stanley, J. L., Chen, Q., James, J. L., Stone, P. R., & Chamley, L. W. (2017). Placental nano-vesicles target to specific organs and modulate vascular tone in vivo. Human Reproduction, 32 (11), 2188-2198. 10.1093/humrep/dex310
    Other University of Auckland co-authors: Qi Chen, Jo James
  • Tong, M., Cheng, S.-B., Chen, Q., DeSousa, J., Stone, P. R., James, J. L., ... Sharma, S. (2017). Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific reports, 7.10.1038/s41598-017-07017-x
    Other University of Auckland co-authors: Qi Chen, Jo James
  • Tong, M., Chen, Q., James, J. L., Stone, P. R., & Chamley, L. W. (2017). Micro- and nano-vesicles from first trimester human placentae carry Flt-1 and levels are increased in severe preeclampsia. Frontiers in Endocrinology, 8.10.3389/fendo.2017.00174
    Other University of Auckland co-authors: Qi Chen, Jo James
  • Tong, M., Chen, Q., James, J. L., Wise, M. R., Stone, P. R., & Chamley, L. W. (2017). In vivo targets of human placental micro-vesicles vary with exposure time and pregnancy. Reproduction, 153 (6), 835-845. 10.1530/REP-16-0615
    Other University of Auckland co-authors: Jo James, Qi Chen, Michelle Wise

Contact details

Primary office location

M&HS BUILDING 502 - Bldg 502
Level 2, Room 201J
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand