Professor Larry William Chamley

PhD, FSRB

Research | Current

Major research interests are

  • Extracellular vesicles
  • The causes of trophoblast deportation and its consequences for maternal physiology.
  • Preeclampsia and recurrent miscarriage
  • The life cycle of human placental trophoblasts.
  • The causes of autoimmune reproductive failure with a focus on events surrounding implantation in and infertility in humans and in particular the effects of antiphospholipid antibodies and antisperm antibodies.
  • The biological function of SPRASA, a sperm protein discovered recently by the research team.

Postgraduate supervision

Mancy Tong (PhD Candidate)

Jia Wei  (PhD Candidate)

Teena Gamage  (PhD Candidate)

Megan Alexander  (PhD Candidate)

Responsibilities

Director of the BSc/BSc(Hons) programme

Areas of expertise

Reproductive biology

Reproductive Immunology

 

Selected publications and creative works (Research Outputs)

  • Umapathy, A., Chamley, L. W., & James, J. L. (2019). Reconciling the distinct roles of angiogenic/anti-angiogenic factors in the placenta and maternal circulation of normal and pathological pregnancies. Angiogenesis10.1007/s10456-019-09694-w
    Other University of Auckland co-authors: Jo James, Anandita Umapathy
  • Acharya, G., Bartolomei, M., Carter, A. M., Chamley, L., Cotton, C. F., Hasegawa, J., ... Konwar, C. (2019). IFPA meeting 2018 workshop report I: Reproduction and placentation among ocean-living species; placental imaging; epigenetics and extracellular vesicles in pregnancy. Placenta, 84, 4-8. 10.1016/j.placenta.2019.02.003
  • Albrecht, C., Chamley, L., Charnock-Jones, D. S., Collins, S., Fujiwara, H., Golos, T., ... Ichizuka, K. (2019). IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery.. Placenta. 10.1016/j.placenta.2019.02.006
  • Gamage, T., Perry, J., Fan, V., Groom, K., Chamley, L., & James, J. (2019). TROPHOBLAST STEM CELLS ISOLATED USING THE SIDE-POPULATION TECHNIQUE ARE DEPLETED IN PLACENTAE FROM GROWTH RESTRICTED PREGNANCIES. Paper presented at Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, JAPAN. 21 September - 24 September 2018. PLACENTA. (pp. 1).
    Other University of Auckland co-authors: Katie Groom
  • Boss, A., Brooks, A., Chamley, L., & James, J. (2019). MEDIA MATTERS: EFFECT OF MEDIA FORMULATIONS ON MESENCHYMAL STEM/STROMAL CELL PURITY AND PHENOTYPE ACROSS GESTATION. Paper presented at Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, JAPAN. 21 September - 24 September 2018. PLACENTA. (pp. 2). 10.1016/j.placenta.2019.06.192
    Other University of Auckland co-authors: Anna Brooks
  • Boss, A., Brooks, A., Chamley, L., & James, J. (2019). PLACENTAL MESENCHYMAL STEM/STROMAL CELLS (PMSCS): COULD THEY CONTRIBUTE TO PLACENTAL VASCULAR DYSFUNCTION IN FGR?. Paper presented at Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, JAPAN. 21 September - 24 September 2018. PLACENTA. (pp. 1). 10.1016/j.placenta.2019.06.098
    Other University of Auckland co-authors: Anna Brooks
  • Mulla, M. J., Pasternak, M. C., Salmon, J. E., Chamley, L. W., & Abrahams, V. M. (2019). Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation. Journal of autoimmunity, 98, 103-112. 10.1016/j.jaut.2018.12.003
  • Nelson, R. A., Salmon, J. E., Chamley, L. W., & Abrahams, V. M. (2019). Viral ssRNA and Viral dsRNA Differentially Modulate Human Trophoblast Responses to Antiphospholipid Antibodies.. Paper presented at 66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Paris, FRANCE. 12 March - 16 March 2019. REPRODUCTIVE SCIENCES. (pp. 1).

Contact details

Primary office location

M&HS BUILDING 502 - Bldg 502
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand