Professor Larry William Chamley

PhD, FSRB

Research | Current

Major research interests are

  • Extracellular vesicles
  • The causes of trophoblast deportation and its consequences for maternal physiology.
  • Preeclampsia and recurrent miscarriage
  • The life cycle of human placental trophoblasts.
  • The causes of autoimmune reproductive failure with a focus on events surrounding implantation in and infertility in humans and in particular the effects of antiphospholipid antibodies and antisperm antibodies.
  • The biological function of SPRASA, a sperm protein discovered recently by the research team.

Postgraduate supervision

Mancy Tong (PhD Candidate)

Jia Wei  (PhD Candidate)

Teena Gamage  (PhD Candidate)

Megan Alexander  (PhD Candidate)

Responsibilities

Director of the BSc/BSc(Hons) programme

Areas of expertise

Reproductive biology

Reproductive Immunology

 

Selected publications and creative works (Research Outputs)

  • Mulla, M. J., Pasternak, M. C., Salmon, J. E., Chamley, L. W., & Abrahams, V. M. (2019). Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation. Journal of autoimmunity, 98, 103-112. 10.1016/j.jaut.2018.12.003
  • Nelson, R. A., Salmon, J. E., Chamley, L. W., & Abrahams, V. M. (2019). Viral ssRNA and Viral dsRNA Differentially Modulate Human Trophoblast Responses to Antiphospholipid Antibodies.. Paper presented at 66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Paris, FRANCE. 12 March - 16 March 2019. REPRODUCTIVE SCIENCES. (pp. 1).
  • Zussman, R., Xu, L., Groom, K., Seers, B. M., Chen, Q., Johny, J. P., ... Hickey, A. J. R. (2019). Antiphospholipid Antibodies Induce ROS Production in First Trimester Placentae: A Contribution to the Pathogenesis of Preeclampsia.. Paper presented at 66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Paris, FRANCE. 12 March - 16 March 2019. REPRODUCTIVE SCIENCES. (pp. 2).
    Other University of Auckland co-authors: Katie Groom, Qi Chen
  • Acharya, G., Bartolomei, M., Carter, A. M., Chamley, L., Cotton, C. F., Hasegawa, J., ... Konwar, C. (2019). IFPA meeting 2018 workshop report I: Reproduction and placentation among ocean-living species; placental imaging; epigenetics and extracellular vesicles in pregnancy. Placenta10.1016/j.placenta.2019.02.003
  • Albrecht, C., Chamley, L., Charnock-Jones, D. S., Collins, S., Fujiwara, H., Golos, T., ... Ichizuka, K. (2019). IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery. Placenta. 10.1016/j.placenta.2019.02.006
  • Thery, C., Witwer, K. W., Aikawa, E., Jose Alcaraz, M., Anderson, J. D., Andriantsitohaina, R., ... Atkin-Smith, G. K. (2019). Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. JOURNAL OF EXTRACELLULAR VESICLES, 8 (1)10.1080/20013078.2018.1535750
    Other University of Auckland co-authors: Cherie Blenkiron, Simon Swift
  • Liu, H., Kang, M., Wang, J., Blenkiron, C., Lee, A., Wise, M., ... Chen, Q. (2018). Estimation of the burden of human placental micro- and nano-vesicles extruded into the maternal blood from 8 to 12 weeks of gestation. Placenta, 72-73, 41-47. 10.1016/j.placenta.2018.10.009
    Other University of Auckland co-authors: Qi Chen, Cherie Blenkiron, Arier Lee
  • Gamage, T. K., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., ... James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics10.1080/15592294.2018.1549462
    Other University of Auckland co-authors: William Schierding, Teena Gamage, Peter Tsai, Jo James

Contact details

Primary office location

M&HS BUILDING 502 - Bldg 502
Level 2, Room 201J
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand