Professor Larry William Chamley

PhD, FSRB

Research | Current

Major research interests are

  • Extracellular vesicles
  • The causes of trophoblast deportation and its consequences for maternal physiology.
  • Preeclampsia and recurrent miscarriage
  • The life cycle of human placental trophoblasts.
  • The causes of autoimmune reproductive failure with a focus on events surrounding implantation in and infertility in humans and in particular the effects of antiphospholipid antibodies and antisperm antibodies.
  • The biological function of SPRASA, a sperm protein discovered recently by the research team.

Postgraduate supervision

Mancy Tong (PhD Candidate)

Jia Wei  (PhD Candidate)

Teena Gamage  (PhD Candidate)

Megan Alexander  (PhD Candidate)

Responsibilities

Director of the BSc/BSc(Hons) programme

Areas of expertise

Reproductive biology

Reproductive Immunology

 

Selected publications and creative works (Research Outputs)

  • Liu, H., Kang, M., Wang, J., Blenkiron, C., Lee, A., Wise, M., ... Chen, Q. (2018). Estimation of the burden of human placental micro- and nano-vesicles extruded into the maternal blood from 8 to 12 weeks of gestation. Placenta, 72-73, 41-47. 10.1016/j.placenta.2018.10.009
    Other University of Auckland co-authors: Qi Chen, Cherie Blenkiron, Arier Lee
  • Boss, A. L., Chamley, L. W., & James, J. L. (2018). Placental formation in early pregnancy: how is the centre of the placenta made?. Human reproduction update, 24 (6), 750-760. 10.1093/humupd/dmy030
    Other University of Auckland co-authors: Jo James
  • Umapathy, A., Lee, A. C. L., Chamley, L., & James, J. (2018). ARE MESENCHYMAL STEM/STROMAL CELLS FROM GROWTH RESTRICTED PLACENTAE POOR STIMULATORS OF ANGIOGENESIS?. Paper presented at Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, JAPAN. 21 September - 24 September 2018. PLACENTA. (pp. 1).
    Other University of Auckland co-authors: Arier Lee
  • Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., ... James, J. L. (2018). GLOBAL DNA METHYLATION LEVELS ARE COMPARABLE BETWEEN TROPHOBLAST POPULATIONS AND MANY SOMATIC CELLS. Paper presented at Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, JAPAN. 21 September - 24 September 2018. PLACENTA. (pp. 1).
    Other University of Auckland co-authors: Jo James, William Schierding
  • Gamage, T. K. J. B., Chamley, L. W., & James, J. L. (2018). REDUCED NUMBERS OF SIDE-POPULATION TROPHOBLASTS IN FETAL GROWTH RESTRICTION PROVIDE CLUES TO PLACENTAL DYSFUNCTION. Paper presented at Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, JAPAN. 21 September - 24 September 2018. PLACENTA. (pp. 1).
    Other University of Auckland co-authors: Jo James
  • Boss, A., James, J. L., Brooks, A. E. S., & Chamley, L. W. (1/9/2018). IN VIVO IDENTIFICATION OF A NOVEL PROGENITOR IN THE MESENCHYMAL CORE OF HUMAN PLACENTAL VILLI. Poster presented at Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, JAPAN. PLACENTA.
    Other University of Auckland co-authors: Anna Brooks, Jo James
  • Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., ... James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology open, 7 (8).10.1242/bio.034884
    Other University of Auckland co-authors: Peter Tsai, Teena Gamage, William Schierding, Jo James
  • Mulla, M. J., Weel, I. C., Potter, J. A., Gysler, S. M., Salmon, J. E., Peraçoli MTS, ... Abrahams, V. M. (2018). Antiphospholipid Antibodies Inhibit Trophoblast Toll-Like Receptor and Inflammasome Negative Regulators. Arthritis & rheumatology (Hoboken, N.J.), 70 (6), 891-902. 10.1002/art.40416