Dr Lydia Pieng Ping Liew

BSc (Hons.) PhD in Chemistry, University of Auckland

Research Fellow

In: Auckland Cancer Society Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

Dr Lydia Liew is an early career research fellow at the Auckland Cancer Society Research Centre, University of Auckland, New Zealand. Lydia is a medicinal chemist with interests in drug design and development. She is currently working on the discovery of molecules to exploit the characteristics of the tumour microenvironment for the treatment of cancer.

Research | Current

Lydia's research is in design, synthesis and development of small molecules that interact with protein targets in the tumour microenvironment. This work is achieved through the computational models which are used to carry out virtual screening of drug-like molecules to predict their potential for interaction at the receptor of interest and complemented with medicinal chemistry.

Teaching | Current

CHEM750 - Drug design

PHARM312/412 - Medicinal Chemistry (in Pain & Rheumatology, Osteoporosis and Anticholinergics & Postural Hypotension modules)

Postgraduate supervision

Masters project

Exploring the structural determinants for PIKK activity

Archana Arya-Ram (co-supervisor)

Committees/Professional groups/Services

Affiliate Investigator, Maurice Wilkins Centre
New Zealand Society for Oncology
Professional Early Career Researcher, Royal Society Te Apārangi
Member, American Chemical Society

Selected publications and creative works (Research Outputs)

Wong, W. W., Jackson, R. K., Liew, L. P., Dickson, B. D., Cheng, G. J., Lipert, B., ... Hay, M. P. (2019). Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361. Biochemical pharmacology, 16910.1016/j.bcp.2019.113641
Other University of Auckland co-authors: Barbara Lipert, Way Wong, Benjamin Dickson, Yongchuan Gu, Francis Hunter, Michael Hay
Jackson, R. K., Liew, L. P., & Hay, M. P. (2019). Overcoming Radioresistance: Small Molecule Radiosensitisers and Hypoxia-activated Prodrugs. Clinical oncology (Royal College of Radiologists (Great Britain)), 31 (5), 290-302. 10.1016/j.clon.2019.02.004
URL: http://hdl.handle.net/2292/48301
Other University of Auckland co-authors: Michael Hay
Liew, L. P., Singleton, D. C., Wong, W. W., Cheng, G. J., Jamieson, S. M. F., & Hay, M. P. (2019). Hypoxia‐Activated Prodrugs of PERK Inhibitors. Chemistry - An Asian Journal, 14 (8), 1238-1248. 10.1002/asia.201801826
URL: http://hdl.handle.net/2292/48401
Other University of Auckland co-authors: Dean Singleton, Way Wong, Stephen Jamieson, Michael Hay
Bonnet, M., Hong, C. R., Wong, W. W., Liew, L. P., Shome, A., Wang, J., ... Anderson, R. F. (2018). Next-generation hypoxic cell radiosensitizers: Nitroimidazole alkylsulfonamides. Journal of Medicinal Chemistry, 61 (3), 1241-1254. 10.1021/acs.jmedchem.7b01678
URL: http://hdl.handle.net/2292/41805
Other University of Auckland co-authors: Michael Hay, Way Wong, Bob Anderson, Stephen Jamieson, Kevin Hicks, Frederik Pruijn, Yongchuan Gu, Ralph Stevenson, Avik Shome, Cho Rong Hong
Hay, M. P., Liew, L., Wong, W., Anderson, R. F., Jamieson, S., & Hicks, K. O. (2017). Next-generation hypoxic cell radiosensitizers: Nitroimidazole alkylsulfonamides. Paper presented at 15th International Workshop on the Tumor Microenvironment: Hypoxia, Angiogenesis& Vasculature, Miami Florida, USA. 27 April - 29 April 2017.
Other University of Auckland co-authors: Stephen Jamieson, Bob Anderson, Michael Hay, Ralph Stevenson, Kevin Hicks
Yuan, W., Jiang, D., Nambiar, D. K., Liew, L. P., Hay, M. P., Bloomstein, J., ... Tibshirani, R. (2017). Chemical Space Mimicry for Drug Discovery. Journal of Chemical Information and Modeling, 57 (4), 875-882. 10.1021/acs.jcim.6b00754
URL: http://hdl.handle.net/2292/34379
Other University of Auckland co-authors: Michael Hay
Hay, M. P., Wong, W. W., Liew, L. P., Shome, A., Jamieson, S. M. F., & Hicks, K. O. (2017). Next-generation hypoxic cell radiosensitisers: Nitroimidazole alkylsulfonamides. Paper presented at New Zealand Society for Oncology Conference, Auckland, New Zealand. 14 October - 15 October 2017. Related URL.
Other University of Auckland co-authors: Michael Hay, Way Wong, Avik Shome, Stephen Jamieson, Kevin Hicks
Liew, L., Burns, E., Jamaluddin, A., Bonnet, M., Flanagan, J., Hay, D., & Hay, M. (2016). Discovery of small molecule modulators of the adrenomedullin 1 (AM₁) receptor. Paper presented at Queenstown Research Week: Cancer Biology, Nelson, New Zealand. 28 August - 29 August 2016.
Other University of Auckland co-authors: Erica Hendrikse, Aqfan Jamaluddin, Jack Flanagan, Debbie Hay, Michael Hay