Dr Lydia Pieng Ping Liew

BSc (Hons.) PhD in Chemistry, University of Auckland

Research Fellow

In: Auckland Cancer Society Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

Dr Lydia Liew is an early career research fellow at the Auckland Cancer Society Research Centre, University of Auckland, New Zealand. Lydia is a medicinal chemist with interests in drug design and development. She is currently working on the discovery of molecules to exploit the characteristics of the tumour microenvironment for the treatment of cancer.

Research | Current

Lydia's research is in design, synthesis and development of small molecules that interact with protein targets in the tumour microenvironment. This work is achieved through the computational models which are used to carry out virtual screening of drug-like molecules to predict their potential for interaction at the receptor of interest and complemented with medicinal chemistry.

Committees/Professional groups/Services

Affiliate Investigator, Maurice Wilkins Centre
New Zealand Society for Oncology

Selected publications and creative works (Research Outputs)

Bonnet, M., Hong, C. R., Wong, W. W., Liew, L. P., Shome, A., Wang, J., ... Anderson, R. F. (2018). Next-generation hypoxic cell radiosensitizers: Nitroimidazole alkylsulfonamides. Journal of Medicinal Chemistry, 61 (3), 1241-1254. 10.1021/acs.jmedchem.7b01678
Other University of Auckland co-authors: Michael Hay, Way Wong, Bob Anderson, Stephen Jamieson, Kevin Hicks, Frederik Pruijn, Yongchuan Gu, Ralph Stevenson, Avik Shome
Liew, L. P., Wong, W. W., Singleton, D. C., Jamieson, S. M. F., Flanagan, J. U., Koumenis, C., & Hay, M. P. (2017). The development of hypoxia-selective prodrugs of the PERK inhibitor. Paper presented at 15th International Tumor Microenvironment Workshop, Miami, Florida. 27 April - 29 April 2017.
URL: http://hdl.handle.net/2292/34511
Other University of Auckland co-authors: Way Wong, Dean Singleton, Stephen Jamieson, Jack Flanagan, Michael Hay
Yuan, W., Jiang, D., Nambiar, D. K., Liew, L. P., Hay, M. P., Bloomstein, J., ... Tibshirani, R. (2017). Chemical Space Mimicry for Drug Discovery. Journal of Chemical Information and Modeling, 57 (4), 875-882. 10.1021/acs.jcim.6b00754
URL: http://hdl.handle.net/2292/34379
Other University of Auckland co-authors: Michael Hay
Liew, L. P. (2015). Structure-based design of small molecule modulators of the adrenomedullin 1 receptor. Paper presented at 13th Annual Discovery on Target, Boston Massachusetts, USA. 21 September - 25 September 2015.
Other University of Auckland co-authors: Erica Hendrikse, Aqfan Jamaluddin, Michael Hay, Debbie Hay
Liew, L. P. P., Fleming, J. M., Longeon, A., Mouray, E., Florent, I., Bourguet-Kondracki, M. L., & Copp, B. R. (2014). Synthesis of 1-indolyl substituted β-carboline natural products and discovery of antimalarial and cytotoxic activities. Tetrahedron, 70 (33), 4910-4920. 10.1016/j.tet.2014.05.068
URL: http://hdl.handle.net/2292/36093
Other University of Auckland co-authors: Brent Copp
Liew, L. P. P., Pearce, A. N., Kaiser, M., & Copp, B. R. (2013). Synthesis and in vitro and in vivo evaluation of antimalarial polyamines. Eur J Med Chem, 69, 22-31. 10.1016/j.ejmech.2013.07.055
URL: http://hdl.handle.net/2292/36485
Other University of Auckland co-authors: Norrie Pearce, Brent Copp
Liew, L. P. P., Kaiser, M., & Copp, B. R. (2013). Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds. Bioorganic and Medicinal Chemistry Letters, 23 (2), 452-454. 10.1016/j.bmcl.2012.11.072
URL: http://hdl.handle.net/2292/36778
Other University of Auckland co-authors: Brent Copp