Dr Liam Argent
Liam earned his first degree (biochemistry) at the University of Bristol before being awarded a D.Phil. (neuroscience) by the University of Oxford. He then moved to Auckland and is currently a Research Fellow in the Cardio-Respiratory Neuroscience Research Group, led by Professor Julian Paton. In general, Liam’s research is focussed on understanding the different structures of the nervous system, from individual ion channels to entire circuits. In particular, he is interested in how structural changes underpin the dynamic functions of the nervous system, for example circuit formation and plasticity.
Research | Current
The clinical consequences for those living with hypertension are severe, yet current treatments are often ineffective. Alarmingly, the prognosis for hypertensive individuals remains poor even if their blood pressure is well controlled, likely because the underlying sympathetic nervous system overdrive that contributes to hypertension is not addressed.
Recent studies suggest that sensitisation of the carotid body, a paraganglia of the peripheral cardio-respiratory nervous system that acts as a multi-modal visceral afferent sensor, drives sympathetic hyperactivity via a reflex loop and that this leads to hypertension. However, the aetiology of carotid body hyperactivity in hypertension is unknown. Liam's current research is therefore focussed on exploring the mechanisms underlying carotid body sensitisation, with the goal of identifying new targets for the treatment of hypertension.
Areas of expertise
Neurobiology and neurophysiology
Selected publications and creative works (Research Outputs)
- Argent, L., Winter, F., Prickett, I., Carrasquero-Ordaz, M., Olsen, A. L., Kramer, H., ... Becker, E. B. E. (2020). Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology. The Journal of biological chemistry, 295 (36), 12716-12726. 10.1074/jbc.ra120.012655
- Ashton, J. L., Argent, L., Smith, J. E. G., Jin, S., Sands, G. B., Smaill, B. H., & Montgomery, J. M. (2020). Evidence of structural and functional plasticity occurring within the intracardiac nervous system of spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology, 318 (6), H1387-H1400. 10.1152/ajpheart.00020.2020
Other University of Auckland co-authors: Jesse Ashton, Gregory Sands, Bruce Smaill, Johanna Montgomery
- Aryal, P., Jarerattanachat, V., Clausen, M. V., Schewe, M., McClenaghan, C., Argent, L., ... Carpenter, E. P. (2017). Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure (London, England : 1993), 25 (5), 708-718.e2. 10.1016/j.str.2017.03.006